Mechanisms of qualitative and quantitative control of skeletal muscle tissue approached by hormones and glycosaminoglycan

KAKEN

About This Project

Japan Grant Number
JP17H03934 (JGN)
Funding Program
Grants-in-Aid for Scientific Research
Funding Organization
Japan Society for the Promotion of Science

Kakenhi Information

Project/Area Number
17H03934
Research Category
Grant-in-Aid for Scientific Research (B)
Allocation Type
  • Single-year Grants
Review Section / Research Field
  • Biological Sciences > Agriculture > Animal life science > Integrative animal science
Research Institution
  • Tottori University
Project Period (FY)
2017-04-01 〜 2020-03-31
Project Status
Completed
Budget Amount*help
15,470,000 Yen (Direct Cost: 11,900,000 Yen Indirect Cost: 3,570,000 Yen)

Research Abstract

Based on histological analysis in the muscle repair process and analysis of chondroitin sulfate (CS) synthesis/degradation-related enzymes, CS is a factor that promotes the regulation of myoblast differentiation and the smooth transition to the differentiation stage of myoblasts. In addition, the tissue analysis and muscle mass recovery in the muscle repair process in the low estrogen (E2) state were analyzed using ovariectomized (OVX) mice and gene-modified mice. Tissue recovery is delayed when muscle damage is induced in a low E2 state, but it is recovered by additional administration of E2 to OVX mice. And it is suggested that E2 receptor Esr2 is involved in muscle regeneration more than Esr1.

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