{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1040000781970380032.json","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"17K12006"},{"@type":"JGN","@value":"JP17K12006"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K12006/"}],"jpcoar:awardTitle":[{"@language":"ja","@value":"高齢者の気管支液フローラの構成と機能、口腔との関連：メタゲノム、メタボローム解析"},{"@language":"en","@value":"Profiling microbiota of bronchial fluids in the elderly and its association with oral cavities"}],"field":[{"keyword":[{"language":"ja","textList":["生物系","医歯薬学","歯学","社会系歯学"]},{"language":"en","textList":["Biological Sciences","Medicine, Dentistry, and Pharmacy","Dentistry","Social dentistry"]}]}],"dc:language":"ja","description":[{"type":"outline_of_research_achievement","notation":[{"@language":"ja","@value":"高齢者の不顕性誤嚥の詳細について明らかにするために、口腔や咽頭部からの細菌混入を避けられるマイクロサンプリングプローブを用いて、気管支液のサンプリングを行い、試料中の細菌量および構成を培養ならびに分子生物学的手法によって明らかにし、咳・嚥下反射の低下程度と比較した。同時に、唾液の細菌叢解析を行い、口腔内細菌との関連性を検討した。その結果、嚥下反射が低下した高齢者では、口腔細菌がより誤嚥されている可能性が示唆された。"},{"@language":"en","@value":"The source of the bacteria involved in silent aspiration remains to be completely defined. The purpose of the present study was to obtain reliable evidence on silent aspiration of oral bacteria in elderly patients. Our results suggest that bacteria in bronchial fluids associated with silent aspiration are derived from saliva, and that the bronchial fluids of elderly patients with an impaired swallowing reflex may have a characteristic microbiota. In addition, our results suggest that oral hygiene is important to reduce silent aspiration and to subsequently prevent the occurrence of aspiration pneumonia in elderly 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