{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1040000782015147904.json","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"19H04470"},{"@type":"JGN","@value":"JP19H04470"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H04470/"}],"jpcoar:awardTitle":[{"@language":"ja","@value":"腫瘤径5mmの超早期膵がんの描出を可能にするインテリジェント型機能化造影剤"},{"@language":"en","@value":"Ultrasensitive MRI detection of spontaneous pancreatic tumors with nanocage-based targeted contrast agent"}],"field":[{"keyword":[{"language":"ja","textList":["小区分90120:生体材料学関連"]},{"language":"en","textList":["Basic Section 90120:Biomaterials-related"]}]}],"dc:language":"ja","description":[{"type":"outline_of_research_initial","notation":[{"@language":"ja","@value":"膵がんは極めて不良であり、早期発見こそが予後を改善する唯一の手段となっている。MRIは組織分解能に優れ、また様々な角度から撮像できることから膵がんの画像診断法として用いられているが、80％以上の5年生存率が期待できる腫瘍径1cm以下のがん部を描出するには、感度も特異性も決定的に不足している。\n本研究では独自のプロテインケージ技術を用いて、直径12nmのナノカプセル型機能化造影剤を分子設計する。そのサイズと剛直性、表面へのアンテナ分子の呈示（分子標的化）、そして細胞シグナルによる構造変化などを制御することによって、膵がんに対する「超高感度化」、「膵がん特異性」、そして「疾患応答性」を付与する。"}]}],"researcher":[{"@id":"https://cir.nii.ac.jp/crid/1420845751167452288","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"90526831"},{"@type":"NRID","@value":"1000090526831"},{"@type":"NRID","@value":"9000004514335"},{"@type":"NRID","@value":"9000006869315"},{"@type":"NRID","@value":"9000023392733"},{"@type":"NRID","@value":"9000001783857"},{"@type":"NRID","@value":"9000024254918"},{"@type":"NRID","@value":"9000017712205"},{"@type":"NRID","@value":"9000406388011"},{"@type":"NRID","@value":"9000258316369"},{"@type":"NRID","@value":"9000380472332"},{"@type":"NRID","@value":"9000018457270"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/takahitok"}],"foaf:name":[{"@language":"ja","@value":"河野 喬仁"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"九州大学"}],"role":"co_investigator_buntan"},{"@id":"https://cir.nii.ac.jp/crid/1420845751148526976","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20452708"},{"@type":"NRID","@value":"1000020452708"},{"@type":"NRID","@value":"9000345303810"},{"@type":"NRID","@value":"9000017577978"},{"@type":"NRID","@value":"9000387476311"},{"@type":"NRID","@value":"9000257921986"},{"@type":"NRID","@value":"9000002940726"},{"@type":"NRID","@value":"9000403036671"},{"@type":"NRID","@value":"9000340945232"},{"@type":"NRID","@value":"9000014162223"},{"@type":"NRID","@value":"9000002937440"},{"@type":"NRID","@value":"9000238936751"},{"@type":"NRID","@value":"9000292181439"},{"@type":"NRID","@value":"9000279638105"},{"@type":"NRID","@value":"9000309577173"},{"@type":"NRID","@value":"9000402276114"},{"@type":"NRID","@value":"9000356583696"},{"@type":"NRID","@value":"9000264271845"}],"foaf:name":[{"@language":"ja","@value":"大内田 研宙"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"九州大学"}],"role":"co_investigator_buntan"},{"@id":"https://cir.nii.ac.jp/crid/1420282801207070080","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30304744"},{"@type":"NRID","@value":"1000030304744"},{"@type":"ORCID","@value":"0000-0002-5625-2245"},{"@type":"NRID","@value":"9000257789832"},{"@type":"NRID","@value":"9000003142247"},{"@type":"NRID","@value":"9000398039618"},{"@type":"NRID","@value":"9000252808728"},{"@type":"NRID","@value":"9000404939476"},{"@type":"NRID","@value":"9000257789370"},{"@type":"NRID","@value":"9000257796993"},{"@type":"NRID","@value":"9000250174639"},{"@type":"NRID","@value":"9000257790362"},{"@type":"NRID","@value":"9000377370223"},{"@type":"NRID","@value":"9000002980281"},{"@type":"NRID","@value":"9000019038282"},{"@type":"NRID","@value":"9000413931560"},{"@type":"NRID","@value":"9000400160669"},{"@type":"NRID","@value":"9000256014882"},{"@type":"NRID","@value":"9000265558829"},{"@type":"NRID","@value":"9000397800834"},{"@type":"NRID","@value":"9000256023615"},{"@type":"NRID","@value":"9000257720650"},{"@type":"NRID","@value":"9000257720078"},{"@type":"NRID","@value":"9000010776549"},{"@type":"NRID","@value":"9000403273599"},{"@type":"NRID","@value":"9000257791114"},{"@type":"NRID","@value":"9000016421639"},{"@type":"NRID","@value":"9000240540138"},{"@type":"NRID","@value":"9000406388012"},{"@type":"NRID","@value":"9000257790439"},{"@type":"NRID","@value":"9000257719500"},{"@type":"NRID","@value":"9000016410915"},{"@type":"NRID","@value":"9000257796146"},{"@type":"NRID","@value":"9000380472334"},{"@type":"NRID","@value":"9000257789720"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/murata-1968"}],"foaf:name":[{"@language":"ja","@value":"村田 正治"},{"@language":"en","@value":"Murata Masaharu"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"九州大学"}],"role":"principal_investigator"}],"since":"2019-04-01","until":"2022-03-31","institution":[{"institutionIdentifier":[{"@type":"NII","@value":"0017102"}],"notation":[{"@language":"ja","@value":"九州大学"},{"@language":"en","@value":"Kyushu University"}]}],"fundingProgram":[{"jpcoar:funderName":[{"@language":"ja","@value":"科学研究費助成事業"},{"@language":"en","@value":"Grants-in-Aid for Scientific Research"}]}],"url":[{"@id":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H04470/","notation":[{"@value":"KAKEN"}]}],"createdAt":"2019-04-18","modifiedAt":"2025-11-20","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=%E3%83%8A%E3%83%8E%E3%83%A1%E3%83%87%E3%82%A3%E3%82%B9%E3%83%B3","dc:title":"ナノメディスン"},{"@id":"https://cir.nii.ac.jp/all?q=MRI","dc:title":"MRI"},{"@id":"https://cir.nii.ac.jp/all?q=%E8%86%B5%E3%81%8C%E3%82%93","dc:title":"膵がん"},{"@id":"https://cir.nii.ac.jp/all?q=%E6%A9%9F%E8%83%BD%E5%8C%96%E9%80%A0%E5%BD%B1%E5%89%A4","dc:title":"機能化造影剤"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%83%8A%E3%83%8E%E6%9D%90%E6%96%99","dc:title":"ナノ材料"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%81%8C%E3%82%93","dc:title":"がん"},{"@id":"https://cir.nii.ac.jp/all?q=%E5%88%86%E5%AD%90%E3%82%A4%E3%83%A1%E3%83%BC%E3%82%B8%E3%83%B3%E3%82%B0","dc:title":"分子イメージング"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%83%8A%E3%83%8E%E3%83%A1%E3%83%87%E3%82%A3%E3%82%B7%E3%83%B3","dc:title":"ナノメディシン"},{"@id":"https://cir.nii.ac.jp/all?q=%E8%A8%BA%E6%96%AD%E3%82%B7%E3%82%B9%E3%83%86%E3%83%A0","dc:title":"診断システム"},{"@id":"https://cir.nii.ac.jp/all?q=%E9%80%A0%E5%BD%B1%E5%89%A4","dc:title":"造影剤"}],"product":[{"@id":"https://cir.nii.ac.jp/crid/1360013168792384512","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"DOI","@value":"10.1016/j.msec.2021.112492"},{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0928493121006329?httpAccept=text/xml"},{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0928493121006329?httpAccept=text/plain"},{"@type":"PMID","@value":"34857278"}],"notation":[{"@value":"Bioinspired macrophage-targeted anti-inflammatory nanomedicine: A therapeutic option for the treatment of myocarditis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360572092387783936","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"DOI","@value":"10.1016/j.jconrel.2020.12.052"},{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0168365920307768?httpAccept=text/xml"},{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0168365920307768?httpAccept=text/plain"},{"@type":"PMID","@value":"33388342"}],"notation":[{"@value":"Protective and healing effects of apoptotic mimic-induced M2-like macrophage polarization on pressure ulcers in young and middle-aged mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360857593723510528","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"DOI","@value":"10.1159/000513289"},{"@type":"URI","@value":"https://www.karger.com/Article/Pdf/513289"},{"@type":"PMID","@value":"33596563"}],"notation":[{"@value":"A Novel Hyperspectral Imaging System for Intraoperative Prediction of Cerebral Hyperperfusion Syndrome after Superficial Temporal Artery-Middle Cerebral Artery Anastomosis in Patients with Moyamoya Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294643761969920","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"DOI","@value":"10.1016/j.freeradbiomed.2021.04.017"},{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0891584921002239?httpAccept=text/xml"},{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0891584921002239?httpAccept=text/plain"},{"@type":"PMID","@value":"33865961"}],"notation":[{"@value":"Development of 20 cm sample bore size dynamic nuclear polarization (DNP)-MRI at 16 mT and redox metabolic imaging of acute hepatitis rat model"}]},{"@id":"https://cir.nii.ac.jp/crid/1360576118746873984","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"DOI","@value":"10.1523/eneuro.0098-21.2021"},{"@type":"URI","@value":"https://syndication.highwire.org/content/doi/10.1523/ENEURO.0098-21.2021"},{"@type":"PMID","@value":"34462309"}],"notation":[{"@value":"Protein Nanoparticles Modified with PDGF-B as a Novel Therapy After Acute Cerebral Infarction"}]},{"@id":"https://cir.nii.ac.jp/crid/1360572092826282624","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"DOI","@value":"10.1038/s41598-020-73336-1"},{"@type":"URI","@value":"https://www.nature.com/articles/s41598-020-73336-1.pdf"},{"@type":"URI","@value":"https://www.nature.com/articles/s41598-020-73336-1"},{"@type":"PMID","@value":"33020535"}],"notation":[{"@value":"Development of a novel molecular probe for the detection of liver mitochondrial redox metabolism"}]},{"@id":"https://cir.nii.ac.jp/crid/1360290617849246208","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"DOI","@value":"10.1021/acs.analchem.0c02331"},{"@type":"URI","@value":"https://pubs.acs.org/doi/pdf/10.1021/acs.analchem.0c02331"},{"@type":"PMID","@value":"33064938"}],"notation":[{"@value":"Imaging of Hydroxyl-Radical Generation Using Dynamic Nuclear Polarization-Magnetic Resonance Imaging and a Spin-Trapping Agent"}]},{"@id":"https://cir.nii.ac.jp/crid/1360576118744324864","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"DOI","@value":"10.1016/j.pan.2020.06.001"},{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S1424390320301915?httpAccept=text/xml"},{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S1424390320301915?httpAccept=text/plain"},{"@type":"PMID","@value":"32622759"}],"notation":[{"@value":"Förster resonance energy transfer (FRET)-Labeled nanoprobe enables real-time diagnosis of pancreatic juice activation due to postoperative pancreatic fistula"}]},{"@id":"https://cir.nii.ac.jp/crid/1360853567782579968","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"DOI","@value":"10.1016/j.intimp.2020.106462"},{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S1567576920304422?httpAccept=text/xml"},{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S1567576920304422?httpAccept=text/plain"},{"@type":"PMID","@value":"32251961"}],"notation":[{"@value":"The farnesyltransferase inhibitor tipifarnib protects against autoimmune hepatitis induced by Concanavalin A"}]},{"@id":"https://cir.nii.ac.jp/crid/1390283659855390720","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"DOI","@value":"10.5650/jos.ess19268"},{"@type":"PMID","@value":"32051357"},{"@type":"NDL_BIB_ID","@value":"030275128"},{"@type":"NDL_CALL_NUMBER","@value":"Z54-J571"},{"@type":"URI","@value":"http://id.ndl.go.jp/bib/030275128"},{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I030275128"},{"@type":"URI","@value":"https://www.jstage.jst.go.jp/article/jos/69/3/69_ess19268/_pdf"},{"@type":"NAID","@value":"130007804109"},{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2020369400"}],"notation":[{"@language":"en","@value":"Effect of Fetal Bovine Serum Concentration on Lysophosphatidylcholine-mediated Proliferation and Apoptosis of Human Aortic Smooth Muscle Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1361131415831324800","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"DOI","@value":"10.1007/s10337-019-03837-3"},{"@type":"URI","@value":"http://link.springer.com/content/pdf/10.1007/s10337-019-03837-3.pdf"},{"@type":"URI","@value":"http://link.springer.com/article/10.1007/s10337-019-03837-3/fulltext.html"}],"notation":[{"@value":"Investigation of the Separation Efficiency of Tube Radial Distribution Chromatography with Stationary Outer Phase Using the van Deemter Equation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848656206891648","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"DOI","@value":"10.1007/s00726-019-02735-0"},{"@type":"URI","@value":"http://link.springer.com/content/pdf/10.1007/s00726-019-02735-0.pdf"},{"@type":"URI","@value":"http://link.springer.com/article/10.1007/s00726-019-02735-0/fulltext.html"},{"@type":"PMID","@value":"31004228"}],"notation":[{"@value":"A high-affinity peptide substrate for G protein-coupled receptor kinase 2 (GRK2)"}]},{"@id":"https://cir.nii.ac.jp/crid/1361975839618487040","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"DOI","@value":"10.1002/lipd.12178"},{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Flipd.12178"},{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/lipd.12178"},{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/full-xml/10.1002/lipd.12178"},{"@type":"URI","@value":"https://aocs.onlinelibrary.wiley.com/doi/pdf/10.1002/lipd.12178"},{"@type":"PMID","@value":"31273804"}],"notation":[{"@value":"Suppression of Lysophosphatidylcholine‐Induced Human Aortic Smooth Muscle Cell Calcification by Protein Kinase A Inhibition"}]}],"dataSourceIdentifier":[{"@type":"KAKEN","@value":"19H04470"}],"grant":{"grantIdentifier":[{"@type":"NII","@value":"69"}],"jpcoar:fundingStream":[{"@language":"ja","@value":"基盤研究(B)"},{"@language":"en","@value":"Grant-in-Aid for Scientific Research (B)"}]},"allocationClassification":[{"notation":[{"@language":"ja","@value":"補助金"},{"@language":"en","@value":"Single-year Grants"}]}],"projectStatus":"project_closed","allocationAmount":{"totalCost":{"amount":"17030000","currency":"JPY"},"breakdownCost":[{"notation":[{"@language":"ja","@value":"直接経費"},{"@language":"en","@value":"Direct Cost"}],"amount":"13100000","currency":"JPY"},{"notation":[{"@language":"ja","@value":"間接経費"},{"@language":"en","@value":"Indirect Cost"}],"amount":"3930000","currency":"JPY"}]}}