{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1040000782018378752.json","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"19K06403"},{"@type":"JGN","@value":"JP19K06403"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K06403/"}],"jpcoar:awardTitle":[{"@language":"ja","@value":"脳弓下器官のアンジオテンシンII誘発性持続性活性は生理的調節機構か病態の発端か"},{"@language":"en","@value":"Is the angiotensin II-induced persistent activity in the subrfornical neurons  physiological or pathological?"}],"field":[{"keyword":[{"language":"ja","textList":["小区分42020:獣医学関連"]},{"language":"en","textList":["Basic Section 42020:Veterinary medical science-related"]}]}],"dc:language":"ja","description":[{"type":"outline_of_research_initial","notation":[{"@language":"ja","@value":"体液量、体液浸透圧、循環機能（血圧、心機能）は末梢の様々な情報が中枢神経系に伝えられ（入力）、統合されて、自律神経系や内分泌系への出力によって調節されている。血圧低下や体液量減少で血液中に増加するアンジオテンシンII（AII）は脳弓下器官（SFO）という組織で主に受容される。我々は、最近、AIIがSFOの神経細胞に持続性の細胞内Ca2+濃度上昇作用を生じることを見いだした。本研究はこのAIIによるSFO細胞の長期刺激作用を細胞・分子レベルで解明することを主目的としている。"}]}],"researcher":[{"@id":"https://cir.nii.ac.jp/crid/1030003658413649024","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50162649"},{"@type":"NRID","@value":"1000050162649"},{"@type":"NRID","@value":"9000018276944"},{"@type":"NRID","@value":"9000402266630"},{"@type":"NRID","@value":"9000000447598"},{"@type":"NRID","@value":"9000257769946"},{"@type":"NRID","@value":"9000021052260"},{"@type":"NRID","@value":"9000397803104"},{"@type":"NRID","@value":"9000257924247"},{"@type":"NRID","@value":"9000257769001"},{"@type":"NRID","@value":"9000257924032"},{"@type":"NRID","@value":"9000000725667"},{"@type":"NRID","@value":"9000021815687"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0049524"}],"foaf:name":[{"@language":"ja","@value":"澁谷 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