Identification and functional analysis of chondroitin sulfatesinvolved in sizing and development of eye

KAKEN

About This Project

Japan Grant Number
JP22590174 (JGN)
Funding Program
Grants-in-Aid for Scientific Research
Funding Organization
Japan Society for the Promotion of Science

Kakenhi Information

Project/Area Number
22590174
Research Category
Grant-in-Aid for Scientific Research (C)
Allocation Type
  • Single-year Grants
Review Section / Research Field
  • Biological Sciences > Medicine, Dentistry, and Pharmacy > Basic medicine > General anatomy (including Histology/Embryology)
Research Institution
  • Tottori University
Project Period (FY)
2010 〜 2012
Project Status
Completed
Budget Amount*help
4,550,000 Yen (Direct Cost: 3,500,000 Yen Indirect Cost: 1,050,000 Yen)

Research Abstract

We tried to identify chondroitin sulfates closely related sizing and morphogenesis of eye and analyze its function. Chondroitin-4-sulfate and chondoritin-6-sulfate and its proteoglycans were distributed in the retina throughout the developmental periods. Especially, decorin, one of the chondroitin sulfate proteoglycans, were present in abundance in the entire eyeball. Injecting anti-decorin antibody in vitreous cavity on embryonic day 5.5 (HH stage 28), the expansion of chick embryo eye was significantly suppressed. However, proliferation and cell proliferation of retical cells were occurred regardless ofthe suppression of eye expansion. The sclera was also thickened and inhibited eye expansion. These results indicated that decorin involved in the determination of retinal formation and eyeball volume and sizing through the regulation of the expansion of the vitreous body.

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