{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1040000782165714432.json","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23590503"},{"@type":"JGN","@value":"JP23590503"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590503/"}],"jpcoar:awardTitle":[{"@language":"ja","@value":"環境常在マイコバクテリアによるTh2バイアス誘導の分子機構"}],"field":[{"keyword":[{"language":"ja","textList":["生物系","医歯薬学","基礎医学","細菌学(含真菌学)"]},{"language":"en","textList":["Biological Sciences","Medicine, Dentistry, and Pharmacy","Basic medicine","Bacteriology (including Mycology)"]}]}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"ja","@value":"Mycobacterium avium complex(MAC)は自然環境に常在する細菌である。MACはそこからヒトに不顕性感染を起こす可能性があると考えられ、これが結核のワクチンであるBCGの防御効果を低下させるという報告が相次いでいる。我々の検討でも、trehalose-6,6'-dimycolate(TDM)を含むMAC脂質は著しい好酸球の浸潤を伴う、非常に強いTh2反応をモルモットに引き起こす事を見出している。結核防御にはTh1免疫応答が必須なので、そのカウンターパートであるTh2応答が惹起される事はBCGの効果を低下させる事になる事が予想される。この応答はMACによる前感作で増強するので、MAC感染によって宿主の免疫状態が変化することが想定された。しかし、興味ある事に丁度TDMを半分にしたような類似脂質、glucose-6-monomycolate(GMM)では全くTh2応答を誘導できなかった。そればかりか、GMMを感作済み個体に接種すると、単核球を中心とする炎症が惹起され、所属リンパ節においてもTDMを用いた時に誘導されるIL-5、IL-10は見られず、反ってIFN-gやTNFの誘導が見られた。ところが、この研究の過程でマイコバクテリアが産生できる、別のミコール酸脂質、glycerol monomycolate(GroMM)が非常に強いTh2応答を誘導できることが明らかになった。GroMMはTDMに匹敵する強度のTh2応答を惹起できたが、TDMとは異なり結核菌標準培地ではほとんど合成されない。しかし最近報告されたGroMM特異的T細胞の存在を考えると、GroMMは生体内環境特異的に産生されている可能性がある。またGroMMとマイコバクテリアの潜伏感染との関係が指摘される中、MACにもそのような感染様式があるのではないか、という可能性を今後追及すべきだと考える。"}]}],"researcher":[{"@id":"https://cir.nii.ac.jp/crid/1030003658669928960","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00254425"},{"@type":"NRID","@value":"1000000254425"},{"@type":"NRID","@value":"9000000363199"},{"@type":"NRID","@value":"9000000500452"},{"@type":"NRID","@value":"9000006842192"},{"@type":"NRID","@value":"9000006713148"},{"@type":"NRID","@value":"9000017734345"},{"@type":"NRID","@value":"9000017331319"},{"@type":"NRID","@value":"9000254813645"},{"@type":"NRID","@value":"9000253180072"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0182797"}],"foaf:name":[{"@language":"ja","@value":"松永 勇"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"京都大学"}],"role":"principal_investigator"},{"@id":"https://cir.nii.ac.jp/crid/1420001326235934848","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80326256"},{"@type":"NRID","@value":"1000080326256"},{"@type":"CINII_AUTHOR_ID","@value":"DA1977430X"},{"@type":"URI","@value":"https://ci.nii.ac.jp/author/DA1977430X#entity"},{"@type":"URI","@value":"https://viaf.org/viaf/NII%7CDA1977430X"},{"@type":"NRID","@value":"9000244016819"},{"@type":"NRID","@value":"9000000275126"},{"@type":"NRID","@value":"9000252774897"},{"@type":"NRID","@value":"9000253021185"},{"@type":"NRID","@value":"9000253019580"},{"@type":"NRID","@value":"9000252774621"},{"@type":"NRID","@value":"9000402902554"},{"@type":"NRID","@value":"9000303159816"},{"@type":"NRID","@value":"9000405643820"},{"@type":"NRID","@value":"9000253175276"},{"@type":"NRID","@value":"9000303163119"},{"@type":"NRID","@value":"9000253021109"},{"@type":"NRID","@value":"9000253021561"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/Nagatoshi"}],"foaf:name":[{"@language":"ja","@value":"藤原 永年"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"大阪市立大学"}],"role":"co_investigator_buntan"}],"since":"2011","until":"2012","institution":[{"institutionIdentifier":[{"@type":"NII","@value":"0014301"}],"notation":[{"@language":"ja","@value":"京都大学"},{"@language":"en","@value":"Kyoto University"}]}],"fundingProgram":[{"jpcoar:funderName":[{"@language":"ja","@value":"科学研究費助成事業"},{"@language":"en","@value":"Grants-in-Aid for Scientific Research"}]}],"url":[{"@id":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590503/","notation":[{"@value":"KAKEN"}]}],"createdAt":"2011-08-04","modifiedAt":"2025-11-17","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=%E3%83%9E%E3%82%A4%E3%82%B3%E3%83%90%E3%82%AF%E3%83%86%E3%83%AA%E3%82%A2","dc:title":"マイコバクテリア"},{"@id":"https://cir.nii.ac.jp/all?q=%E8%84%82%E8%B3%AA","dc:title":"脂質"},{"@id":"https://cir.nii.ac.jp/all?q=%E5%85%8D%E7%96%AB%E5%BF%9C%E7%AD%94","dc:title":"免疫応答"}],"product":[{"@id":"https://cir.nii.ac.jp/crid/1360004232000231296","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"DOI","@value":"10.1016/j.bbrc.2011.04.146"},{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0006291X11007583?httpAccept=text/xml"},{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0006291X11007583?httpAccept=text/plain"},{"@type":"PMID","@value":"21575604"}],"notation":[{"@value":"Glycerol monomycolate, a latent 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