Remodeling of the intramuscular connective tissues by adipocytes in skeletal muscle

KAKEN

About This Project

Japan Grant Number
JP24658222 (JGN)
Funding Program
Grants-in-Aid for Scientific Research
Funding Organization
Japan Society for the Promotion of Science

Kakenhi Information

Project/Area Number
24658222
Research Category
Grant-in-Aid for Challenging Exploratory Research
Allocation Type
  • Single-year Grants
Review Section / Research Field
  • Biological Sciences > Agriculture > Zootechnical science/Veterinary medical science > Zootechnical science/Grassland science
Research Institution
  • Hokkaido University
Project Period (FY)
2012-04-01 〜 2014-03-31
Project Status
Completed
Budget Amount*help
4,030,000 Yen (Direct Cost: 3,100,000 Yen Indirect Cost: 930,000 Yen)

Research Abstract

In well fattened beef cattle, the intramuscular fat deposits mainly in the intramuscular connective tissues (IMCT) between muscle fiber bundles, resulting in marbling in meat. However, it is still unknown how adipocytes grow in the niche between muscle fiber bundles. In this study, we investigated effects of adipocytes on the remodeling of IMCT in vitro and in vivo. First, we established a new cell culturing method using the intact IMCT as a scaffold for adipocytes and showed that adipocytes partially remodeled the IMCT after 14 days culturing. Next, we examined the structural changes in IMCT in glycerol-injected fatty degenerating muscle, which has been reported to induce adipose tissue development in skeletal muscle. We observed adipose tissues surrounding fibrous connective tissues particularly in the peripheral region of injected muscle at 10 days after injection. These results suggest that adipocytes could remodel the IMCT to the suitable environment for themselves.

Related Articles

See more

Related Data

See more

Related Books

See more

Related Dissertations

See more

Related Projects

See more

Related Products

See more

Keywords

Details 詳細情報について

Back to top