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Identification and clarification of chondroitin sulfate subtype which controls skeletal muscle differentiation
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- HOSAKA Yoshinao
- Principal Investigator
- 鳥取大学
-
- 田村 純一
- Co-Investigator
- 鳥取大学
About This Project
- Japan Grant Number
- JP26450444 (JGN)
- Funding Program
- Grants-in-Aid for Scientific Research
- Funding Organization
- Japan Society for the Promotion of Science
Kakenhi Information
- Project/Area Number
- 26450444
- Research Category
- Grant-in-Aid for Scientific Research (C)
- Allocation Type
-
- Multi-year Fund
- Review Section / Research Field
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- Biological Sciences > Agriculture > Animal life science > Integrative animal science
- Research Institution
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- Tottori University
- Project Period (FY)
- 2014-04-01 〜 2017-03-31
- Project Status
- Completed
- Budget Amount*help
- 5,070,000 Yen (Direct Cost: 3,900,000 Yen Indirect Cost: 1,170,000 Yen)
Research Abstract
In order to clarify the control ability of skeletal muscle differentiation of chondroitin sulfate (CS), five types of CS (CS-A, B, C, D and E) were added to myoblast C2C12 which can reproduce skeletal muscle differentiation process, and differentiation was carried out for a certain period of time. The value of myotube fusion index (FI) calculated from the number of nuclei in the myotubes was used as an index of muscle differentiation. As a result, all CS subtypes used in this reserch suppressed myotube formation, among which CS-E showed remarkable suppression. Moreover, myotube FI decreased concentration-dependent manner. Conversely, knocking down the decorin of CS proteoglycan of C2C12, the muscular differentiation promoted in reverse. From the above, it has clarified that CS have a strong potential to regulate the muscle differentiation.