{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1040004222006908160.json","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"20K22742"},{"@type":"JGN","@value":"JP20K22742"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K22742/"}],"jpcoar:awardTitle":[{"@language":"ja","@value":"数理モデルと実験の融合による顆粒球分葉核形成機構の解明"},{"@language":"en","@value":"Mechanisms of nuclear segmentation in granulocytes"}],"field":[{"keyword":[{"language":"ja","textList":["0802:生体の構造と機能およびその関連分野"]},{"language":"en","textList":["0802:Biomedical structure and function and related fields"]}]}],"dc:language":"ja","description":[{"type":"outline_of_research_initial","notation":[{"@language":"ja","@value":"本研究の目的は，好中球などの成熟顆粒球にみられる分葉した核形態がどのようにして生じるのかを明らかにすることである．真核細胞の核は典型的には球状や楕円球状とされている．しかし，自然免疫を担う顆粒球の核は分化・成熟に伴い球状，桿状を経て分葉した構造に変化する．この形態変化のメカニズムは明らかになっていない．本研究では，核膜と内部構造の動態を粗視化して数理モデル化を行うことで細胞レベルの形態形成機構を予測する．加えて，生物学的実験による検証を組み合わせることで，この特異な核形態形成機構の原理を解明することを目指す．"}]}],"researcher":[{"@id":"https://cir.nii.ac.jp/crid/1420285329318020224","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80875881"},{"@type":"NRID","@value":"1000080875881"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/ksugihara"}],"foaf:name":[{"@language":"ja","@value":"杉原 圭"},{"@language":"en","@value":"Sugihara Kei"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"九州大学"}],"role":"principal_investigator"}],"since":"2020-09-11","until":"2023-03-31","institution":[{"institutionIdentifier":[{"@type":"NII","@value":"0017102"}],"notation":[{"@language":"ja","@value":"九州大学"},{"@language":"en","@value":"Kyushu University"}]}],"fundingProgram":[{"jpcoar:funderName":[{"@language":"ja","@value":"科学研究費助成事業"},{"@language":"en","@value":"Grants-in-Aid for Scientific Research"}]}],"url":[{"@id":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K22742/","notation":[{"@value":"KAKEN"}]}],"createdAt":"2020-09-29","modifiedAt":"2025-11-20","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=%E6%A0%B8%E5%88%86%E8%91%89","dc:title":"核分葉"},{"@id":"https://cir.nii.ac.jp/all?q=%E9%A1%86%E7%B2%92%E7%90%83","dc:title":"顆粒球"},{"@id":"https://cir.nii.ac.jp/all?q=%E5%A5%BD%E4%B8%AD%E7%90%83","dc:title":"好中球"},{"@id":"https://cir.nii.ac.jp/all?q=%E6%95%B0%E7%90%86%E3%83%A2%E3%83%87%E3%83%AB","dc:title":"数理モデル"},{"@id":"https://cir.nii.ac.jp/all?q=%E5%BD%A2%E6%85%8B%E5%BD%A2%E6%88%90","dc:title":"形態形成"},{"@id":"https://cir.nii.ac.jp/all?q=%E6%A0%B8%E8%86%9C","dc:title":"核膜"},{"@id":"https://cir.nii.ac.jp/all?q=%E6%A0%B8%E3%83%A9%E3%83%9F%E3%83%8A","dc:title":"核ラミナ"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%82%AF%E3%83%AD%E3%83%9E%E3%83%81%E3%83%B3","dc:title":"クロマチン"},{"@id":"https://cir.nii.ac.jp/all?q=%E5%88%86%E8%91%89%E6%A0%B8","dc:title":"分葉核"}],"dataSourceIdentifier":[{"@type":"KAKEN","@value":"20K22742"}],"grant":{"grantIdentifier":[{"@type":"NII","@value":"76"}],"jpcoar:fundingStream":[{"@language":"ja","@value":"研究活動スタート支援"},{"@language":"en","@value":"Grant-in-Aid for Research Activity Start-up"}]},"allocationClassification":[{"notation":[{"@language":"ja","@value":"基金"},{"@language":"en","@value":"Multi-year Fund"}]}],"projectStatus":"project_closed","allocationAmount":{"totalCost":{"amount":"2860000","currency":"JPY"},"breakdownCost":[{"notation":[{"@language":"ja","@value":"直接経費"},{"@language":"en","@value":"Direct Cost"}],"amount":"2200000","currency":"JPY"},{"notation":[{"@language":"ja","@value":"間接経費"},{"@language":"en","@value":"Indirect Cost"}],"amount":"660000","currency":"JPY"}]}}