{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1040014327096029696.json","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23K05734"},{"@type":"JGN","@value":"JP23K05734"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K05734/"}],"jpcoar:awardTitle":[{"@language":"ja","@value":"飲酒による発がんと酒酔いのメカニズムの解明"},{"@language":"en","@value":"Molecular mechanisms of carcinogenesis and symptoms associated with alcohol consumption"}],"field":[{"keyword":[{"language":"ja","textList":["小区分43050:ゲノム生物学関連"]},{"language":"en","textList":["Basic Section 43050:Genome biology-related"]}]}],"dc:language":"ja","description":[{"type":"outline_of_research_initial","notation":[{"@language":"ja","@value":"飲酒によって体内に生じるアセトアルデヒドは、飲酒の際に酒酔い(頭痛や嘔吐など)を引き起こし、長期的には発がん率の上昇の原因にもなっている。しかしながら、アセトアルデヒドが、どのように酒酔いやがんを引き起こしているのか、その詳細なメカニズムは不明である。申請者は、アセトアルデヒドによってDNA損傷の一種、DNA二重鎖切断が引き起こされることを発見した。本研究では、アセトアルデヒドによるDNA二重鎖切断形成の分子メカニズムと細胞内応答を明らかにすることで、飲酒による発がんと酒酔いのメカニズムを理解することを目的とする。"}]}],"researcher":[{"@id":"https://cir.nii.ac.jp/crid/1420001326206591104","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10772147"},{"@type":"NRID","@value":"1000010772147"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/Kenichiro_Matsuzaki"}],"foaf:name":[{"@language":"ja","@value":"松嵜 健一郎"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"近畿大学"}],"role":"principal_investigator"}],"since":"2023-04-01","until":"2026-03-31","institution":[{"institutionIdentifier":[{"@type":"NII","@value":"383058"}],"notation":[{"@language":"ja","@value":"近畿大学"},{"@language":"en","@value":"Kindai University"}]}],"fundingProgram":[{"jpcoar:funderName":[{"@language":"ja","@value":"科学研究費助成事業"},{"@language":"en","@value":"Grants-in-Aid for Scientific Research"}]}],"url":[{"@id":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K05734/","notation":[{"@value":"KAKEN"}]}],"createdAt":"2023-04-13","modifiedAt":"2025-12-26","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=%E3%82%A2%E3%82%BB%E3%83%88%E3%82%A2%E3%83%AB%E3%83%87%E3%83%92%E3%83%89","dc:title":"アセトアルデヒド"},{"@id":"https://cir.nii.ac.jp/all?q=DSB","dc:title":"DSB"},{"@id":"https://cir.nii.ac.jp/all?q=%E9%A3%B2%E9%85%92","dc:title":"飲酒"},{"@id":"https://cir.nii.ac.jp/all?q=DNA%E6%90%8D%E5%82%B7","dc:title":"DNA損傷"},{"@id":"https://cir.nii.ac.jp/all?q=%E9%85%92%E9%85%94%E3%81%84","dc:title":"酒酔い"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%82%A2%E3%83%AB%E3%82%B3%E3%83%BC%E3%83%AB","dc:title":"アルコール"}],"product":[{"@id":"https://cir.nii.ac.jp/crid/1360588379381176704","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"DOI","@value":"10.1093/nar/gkae263"},{"@type":"URI","@value":"https://academic.oup.com/nar/article-pdf/52/10/5774/58172784/gkae263.pdf"}],"notation":[{"@value":"Human AAA+ ATPase FIGNL1 suppresses RAD51-mediated ultra-fine bridge formation"}]}],"dataSourceIdentifier":[{"@type":"KAKEN","@value":"23K05734"}],"grant":{"grantIdentifier":[{"@type":"NII","@value":"72"}],"jpcoar:fundingStream":[{"@language":"ja","@value":"基盤研究(C)"},{"@language":"en","@value":"Grant-in-Aid for Scientific Research (C)"}]},"allocationClassification":[{"notation":[{"@language":"ja","@value":"基金"},{"@language":"en","@value":"Multi-year Fund"}]}],"projectStatus":"granted","allocationAmount":{"totalCost":{"amount":"4680000","currency":"JPY"},"breakdownCost":[{"notation":[{"@language":"ja","@value":"直接経費"},{"@language":"en","@value":"Direct Cost"}],"amount":"3600000","currency":"JPY"},{"notation":[{"@language":"ja","@value":"間接経費"},{"@language":"en","@value":"Indirect Cost"}],"amount":"1080000","currency":"JPY"}]}}