{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1040014327096816512.json","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23K07334"},{"@type":"JGN","@value":"JP23K07334"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K07334/"}],"jpcoar:awardTitle":[{"@language":"ja","@value":"不均一かつ多様なミクログリア構成にもとづく脱髄性疾患の新規治療点の解明"}],"field":[{"keyword":[{"language":"ja","textList":["小区分52050:胎児医学および小児成育学関連"]},{"language":"en","textList":["Basic Section 52050:Embryonic medicine and pediatrics-related"]}]}],"dc:language":"ja","description":[{"type":"outline_of_research_initial","notation":[{"@language":"ja","@value":"小児の後天性脱髄性症候群(Acquired Demyelinating Syndrome: ADS)は、急性散在性脳脊髄炎、多発性硬化症、MOG抗体関連疾患など、多彩な臨床病型を含む疾患群の総称である。ADSの5-10%は15歳未満の小児に発症するが、若年発症に寄与する生物学的メカニズムは不明である。本研究では、ADS患児由来誘導脳オルガノイドおよびミクログリア(induced microglia-like cells: iMG)を用いた、新しいヒト脳疾患モデルを構築する。iMG内の遺伝子発現・代謝プロファイルを網羅的に解析し、臨床上有用な活動性指標および治療標的を抽出する。本研究を通して、小児ADSを克服するための分子医学的エビデンスを創出する。"}]}],"researcher":[{"@id":"https://cir.nii.ac.jp/crid/1420564276181718784","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10380396"},{"@type":"NRID","@value":"1000010380396"},{"@type":"NRID","@value":"9000002060691"},{"@type":"NRID","@value":"9000402436456"},{"@type":"NRID","@value":"9000324662898"},{"@type":"NRID","@value":"9000398127835"},{"@type":"NRID","@value":"9000402245388"},{"@type":"NRID","@value":"9000414109531"},{"@type":"NRID","@value":"9000324663235"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/ysakai22q13"}],"foaf:name":[{"@language":"ja","@value":"酒井 康成"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"九州大学"}],"role":"principal_investigator"},{"@id":"https://cir.nii.ac.jp/crid/1420001326219637120","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30550850"},{"@type":"NRID","@value":"1000030550850"},{"@type":"NRID","@value":"9000311774439"},{"@type":"NRID","@value":"9000242901592"}],"foaf:name":[{"@language":"ja","@value":"瀬戸山 大樹"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"九州大学"}],"role":"co_investigator_buntan"},{"@id":"https://cir.nii.ac.jp/crid/1420001326224124032","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70546465"},{"@type":"NRID","@value":"1000070546465"},{"@type":"CINII_AUTHOR_ID","@value":"DA19674509"},{"@type":"URI","@value":"https://ci.nii.ac.jp/author/DA19674509#entity"},{"@type":"URI","@value":"https://viaf.org/viaf/NII%7CDA19674509"},{"@type":"NRID","@value":"9000017577808"},{"@type":"NRID","@value":"9000322104386"},{"@type":"NRID","@value":"9000263059185"},{"@type":"NRID","@value":"9000411953801"},{"@type":"NRID","@value":"9000408480982"},{"@type":"NRID","@value":"9000018662401"},{"@type":"NRID","@value":"9000411830964"},{"@type":"NRID","@value":"9000370733030"},{"@type":"NRID","@value":"9000342453794"},{"@type":"NRID","@value":"9000399560377"},{"@type":"NRID","@value":"9000403262447"},{"@type":"NRID","@value":"9000338430116"},{"@type":"NRID","@value":"9000363170981"},{"@type":"NRID","@value":"9000414259864"},{"@type":"NRID","@value":"9000381068125"},{"@type":"NRID","@value":"9000382649097"},{"@type":"NRID","@value":"9000368928084"},{"@type":"NRID","@value":"9000414259907"},{"@type":"NRID","@value":"9000263059221"},{"@type":"NRID","@value":"9000410959761"},{"@type":"NRID","@value":"9000356551519"},{"@type":"NRID","@value":"9000409279235"},{"@type":"NRID","@value":"9000398459018"},{"@type":"NRID","@value":"9000415162130"},{"@type":"NRID","@value":"9000356612888"},{"@type":"NRID","@value":"9000402802519"},{"@type":"NRID","@value":"9000414543748"},{"@type":"NRID","@value":"9000399158382"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/takahiro_a_kato"}],"foaf:name":[{"@language":"ja","@value":"加藤 隆弘"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"九州大学"}],"role":"co_investigator_buntan"}],"since":"2023-04-01","until":"2026-03-31","institution":[{"institutionIdentifier":[{"@type":"NII","@value":"0017102"}],"notation":[{"@language":"ja","@value":"九州大学"},{"@language":"en","@value":"Kyushu University"}]}],"fundingProgram":[{"jpcoar:funderName":[{"@language":"ja","@value":"科学研究費助成事業"},{"@language":"en","@value":"Grants-in-Aid for Scientific Research"}]}],"url":[{"@id":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K07334/","notation":[{"@value":"KAKEN"}]}],"createdAt":"2023-04-13","modifiedAt":"2025-12-26","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=%E3%83%9F%E3%82%AF%E3%83%AD%E3%82%B0%E3%83%AA%E3%82%A2","dc:title":"ミクログリア"},{"@id":"https://cir.nii.ac.jp/all?q=%E7%82%8E%E7%97%87%E6%80%A7%E3%82%B7%E3%82%B0%E3%83%8A%E3%83%AB","dc:title":"炎症性シグナル"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%83%9F%E3%83%88%E3%82%B3%E3%83%B3%E3%83%89%E3%83%AA%E3%82%A2","dc:title":"ミトコンドリア"},{"@id":"https://cir.nii.ac.jp/all?q=%E8%87%AA%E7%84%B6%E5%85%8D%E7%96%AB","dc:title":"自然免疫"},{"@id":"https://cir.nii.ac.jp/all?q=PKM2","dc:title":"PKM2"},{"@id":"https://cir.nii.ac.jp/all?q=%E4%B8%8D%E5%9D%87%E4%B8%80%E6%80%A7","dc:title":"不均一性"},{"@id":"https://cir.nii.ac.jp/all?q=%E5%80%8B%E4%BA%BA%E5%B7%AE","dc:title":"個人差"},{"@id":"https://cir.nii.ac.jp/all?q=CD14","dc:title":"CD14"},{"@id":"https://cir.nii.ac.jp/all?q=%E8%84%B1%E9%AB%84","dc:title":"脱髄"},{"@id":"https://cir.nii.ac.jp/all?q=%E5%A4%9A%E6%A7%98%E6%80%A7","dc:title":"多様性"},{"@id":"https://cir.nii.ac.jp/all?q=%E9%81%BA%E4%BC%9D%E5%AD%90%E7%99%BA%E7%8F%BE","dc:title":"遺伝子発現"}],"product":[{"@id":"https://cir.nii.ac.jp/crid/1360588380592323200","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"DOI","@value":"10.1242/dmm.050574"},{"@type":"URI","@value":"https://journals.biologists.com/dmm/article-pdf/doi/10.1242/dmm.050574/3467025/dmm050574.pdf"},{"@type":"URI","@value":"https://journals.biologists.com/dmm/article-pdf/doi/10.1242/dmm.050574/3536947/dmm050574.pdf"}],"notation":[{"@value":"ATP1A3 regulates protein synthesis for mitochondrial stability under heat stress"}]},{"@id":"https://cir.nii.ac.jp/crid/1360025430191001216","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"DOI","@value":"10.1038/s41598-025-88721-x"},{"@type":"URI","@value":"https://www.nature.com/articles/s41598-025-88721-x.pdf"},{"@type":"URI","@value":"https://www.nature.com/articles/s41598-025-88721-x"}],"notation":[{"@value":"Expanding diversity in developmental profiles of very-low-birth-weight infants during 6 years after birth"}]},{"@id":"https://cir.nii.ac.jp/crid/1360869854346489472","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"DOI","@value":"10.1159/000541129"},{"@type":"URI","@value":"https://karger.com/neo/article-pdf/doi/10.1159/000541129/4288169/000541129.pdf"}],"notation":[{"@value":"Neurodevelopmental Changes and Postnatal Growth in the First 3 Years of Extremely Preterm Infants"}]},{"@id":"https://cir.nii.ac.jp/crid/1360865815670504576","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"DOI","@value":"10.1007/s12185-024-03721-3"},{"@type":"URI","@value":"https://link.springer.com/content/pdf/10.1007/s12185-024-03721-3.pdf"},{"@type":"URI","@value":"https://link.springer.com/article/10.1007/s12185-024-03721-3/fulltext.html"},{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2025208918"}],"notation":[{"@value":"Early hematopoietic cell transplantation for familial hemophagocytic lymphohistiocytosis in a regional treatment network in Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1360588379382240384","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"DOI","@value":"10.1111/1348-0421.13199"},{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/1348-0421.13199"}],"notation":[{"@value":"Genome Analysis of Japanese <i>Yersinia pseudotuberculosis</i> Strains Isolated From Kawasaki Disease Patients and Other Sources and Their Phylogenetic Positions in the Global <i>Y. pseudotuberculosis</i> Population"}]},{"@id":"https://cir.nii.ac.jp/crid/1360865815671174144","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"DOI","@value":"10.1016/j.clim.2023.109756"},{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S1521661623005193?httpAccept=text/xml"},{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S1521661623005193?httpAccept=text/plain"},{"@type":"PMID","@value":"37678717"}],"notation":[{"@value":"Heterogeneity and mitochondrial vulnerability configurate the divergent immunoreactivity of human induced microglia-like cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360584341824280448","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"DOI","@value":"10.1038/s41598-023-41456-z"},{"@type":"URI","@value":"https://www.nature.com/articles/s41598-023-41456-z.pdf"},{"@type":"URI","@value":"https://www.nature.com/articles/s41598-023-41456-z"},{"@type":"DOI","@value":"10.21203/rs.3.rs-3072308/v1"},{"@type":"URI","@value":"https://www.researchsquare.com/article/rs-3072308/v1"},{"@type":"URI","@value":"https://www.researchsquare.com/article/rs-3072308/v1.html"},{"@type":"PMID","@value":"37684266"}],"notation":[{"@value":"Angiogenic and inflammatory responses in human induced microglia-like (iMG) cells from patients with Moyamoya disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360302865552255360","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"DOI","@value":"10.1002/mgg3.2427"},{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/mgg3.2427"}],"notation":[{"@value":"Rapid and long‐lasting efficacy of high‐dose ambroxol therapy for neuronopathic Gaucher disease: A case report and literature review"}]},{"@id":"https://cir.nii.ac.jp/crid/1360584339752555136","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"DOI","@value":"10.1016/j.pediatrneurol.2023.12.010"},{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0887899423004514?httpAccept=text/xml"},{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0887899423004514?httpAccept=text/plain"}],"notation":[{"@value":"The Etiology and Outcome of Area Postrema Syndrome in Childhood: Two Cases and a Literature Review"}]},{"@id":"https://cir.nii.ac.jp/crid/1360021389826810496","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"DOI","@value":"10.1172/jci171235"},{"@type":"URI","@value":"https://www.jci.org/articles/view/171235/files/pdf"},{"@type":"PMID","@value":"37962958"},{"@type":"HANDLE","@value":"https://repository.ubn.ru.nl/handle/2066/304417"},{"@type":"HANDLE","@value":"11591/515288"},{"@type":"HANDLE","@value":"20.500.11769/638220"}],"notation":[{"@value":"Spliceosome malfunction causes neurodevelopmental disorders with overlapping features"}]}],"dataSourceIdentifier":[{"@type":"KAKEN","@value":"23K07334"}],"grant":{"grantIdentifier":[{"@type":"NII","@value":"72"}],"jpcoar:fundingStream":[{"@language":"ja","@value":"基盤研究(C)"},{"@language":"en","@value":"Grant-in-Aid for Scientific Research (C)"}]},"allocationClassification":[{"notation":[{"@language":"ja","@value":"基金"},{"@language":"en","@value":"Multi-year Fund"}]}],"projectStatus":"granted","allocationAmount":{"totalCost":{"amount":"4680000","currency":"JPY"},"breakdownCost":[{"notation":[{"@language":"ja","@value":"直接経費"},{"@language":"en","@value":"Direct Cost"}],"amount":"3600000","currency":"JPY"},{"notation":[{"@language":"ja","@value":"間接経費"},{"@language":"en","@value":"Indirect Cost"}],"amount":"1080000","currency":"JPY"}]}}