{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1040014327097194368.json","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23K08175"},{"@type":"JGN","@value":"JP23K08175"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K08175/"}],"jpcoar:awardTitle":[{"@language":"ja","@value":"scRNAseqによる血液循環腫瘍細胞検出と腫瘍内空間的トランスクリプトミクス"}],"field":[{"keyword":[{"language":"ja","textList":["小区分55020:消化器外科学関連"]},{"language":"en","textList":["Basic Section 55020:Digestive surgery-related"]}]}],"dc:language":"ja","description":[{"type":"outline_of_research_initial","notation":[{"@language":"ja","@value":"膵癌細胞は非常に転移、浸潤能が高いことが広く知られており、明らかな転移が指摘できる前の段階から血液に腫瘍細胞が循環している可能性が示唆されている。しかし、実際に血液中を循環している腫瘍細胞がどのようにして膵癌組織内で免疫寛容を獲得しどのようにして血中に流入したかなど複雑な微小環境を持つ膵癌組織中での動態は全く不明である。\n本研究では、血液中の腫瘍細胞・膵癌組織のscRNA-seqと膵癌組織の空間的遺伝子発現解析 (Visium)を用いることにより、膵癌微小環境の複雑な相互関係を解明する。"}]}],"researcher":[{"@id":"https://cir.nii.ac.jp/crid/1420282801204429568","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00788432"},{"@type":"NRID","@value":"1000000788432"}],"foaf:name":[{"@language":"ja","@value":"進藤 幸治"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"九州大学"}],"role":"principal_investigator"},{"@id":"https://cir.nii.ac.jp/crid/1420845751154290944","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70586859"},{"@type":"NRID","@value":"1000070586859"},{"@type":"ORCID","@value":"0000-0001-7114-7040"},{"@type":"NRID","@value":"9000006450457"}],"foaf:name":[{"@language":"ja","@value":"森山 大樹"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"九州大学"}],"role":"co_investigator_buntan"},{"@id":"https://cir.nii.ac.jp/crid/1420845751145565696","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"90761015"},{"@type":"NRID","@value":"1000090761015"}],"foaf:name":[{"@language":"ja","@value":"永吉 絹子"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"九州大学"}],"role":"co_investigator_buntan"}],"since":"2023-04-01","until":"2026-03-31","institution":[{"institutionIdentifier":[{"@type":"NII","@value":"0017102"}],"notation":[{"@language":"ja","@value":"九州大学"},{"@language":"en","@value":"Kyushu University"}]}],"fundingProgram":[{"jpcoar:funderName":[{"@language":"ja","@value":"科学研究費助成事業"},{"@language":"en","@value":"Grants-in-Aid for Scientific Research"}]}],"url":[{"@id":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K08175/","notation":[{"@value":"KAKEN"}]}],"createdAt":"2023-04-13","modifiedAt":"2025-12-26","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=scRNA-seq","dc:title":"scRNA-seq"},{"@id":"https://cir.nii.ac.jp/all?q=%E8%86%B5%E7%99%8C","dc:title":"膵癌"},{"@id":"https://cir.nii.ac.jp/all?q=%E7%99%8C%E5%BE%AE%E5%B0%8F%E7%92%B0%E5%A2%83","dc:title":"癌微小環境"},{"@id":"https://cir.nii.ac.jp/all?q=signature%20gene","dc:title":"signature gene"},{"@id":"https://cir.nii.ac.jp/all?q=%E6%B6%88%E5%8C%96%E5%99%A8%E7%99%8C","dc:title":"消化器癌"},{"@id":"https://cir.nii.ac.jp/all?q=%E5%BE%AE%E5%B0%8F%E7%92%B0%E5%A2%83","dc:title":"微小環境"},{"@id":"https://cir.nii.ac.jp/all?q=%E8%A1%80%E6%B6%B2%E5%BE%AA%E7%92%B0%E8%85%AB%E7%98%8D%E7%B4%B0%E8%83%9E","dc:title":"血液循環腫瘍細胞"},{"@id":"https://cir.nii.ac.jp/all?q=%E7%A9%BA%E9%96%93%E7%9A%84%E9%81%BA%E4%BC%9D%E5%AD%90%E7%99%BA%E7%8F%BE%E8%A7%A3%E6%9E%90","dc:title":"空間的遺伝子発現解析"}],"product":[{"@id":"https://cir.nii.ac.jp/crid/1360869855578902528","@type":"Article","resourceType":"学術雑誌論文(journal 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