{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1040018274933339136.json","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"24K09939"},{"@type":"JGN","@value":"JP24K09939"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K09939/"}],"jpcoar:awardTitle":[{"@language":"ja","@value":"フェロトーシスを標的としたがん悪液質の予防薬・治療薬の探索と効果の検証"}],"field":[{"keyword":[{"language":"ja","textList":["小区分47060:医療薬学関連"]},{"language":"en","textList":["Basic Section 47060:Clinical pharmacy-related"]}]}],"dc:language":"ja","description":[{"type":"outline_of_research_initial","notation":[{"@language":"ja","@value":"がん悪液質は体重減少、骨格筋量減少などを症状とした合併症であり、がん患者の予後に大きな影響を与える。2021年にグレリン様作用薬アナモレリンが上市されたが、臨床において悪液質をコントロールする薬剤の選択肢は少なく、新たな悪液質治療薬が求められる。近年、がん悪液質における筋委縮に亜鉛トランスポーターであるZIP14の発現増加が関与することが報告された。 そこで、本研究課題では、がん悪液質を模倣した筋委縮細胞モデルおよび動物モデルを活用し、がん悪液質時の筋委縮におけるフェロトーシスおよび鉄の関与やそのメカニズムを明らかとし、フェロトーシスを標的とした軽減薬の探索と予防法の確立を行う。"}]}],"researcher":[{"@id":"https://cir.nii.ac.jp/crid/1420001326227262592","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00403973"},{"@type":"NRID","@value":"1000000403973"}],"foaf:name":[{"@language":"ja","@value":"小林 大介"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"九州大学"}],"role":"principal_investigator"},{"@id":"https://cir.nii.ac.jp/crid/1420845751138780928","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30621685"},{"@type":"NRID","@value":"1000030621685"},{"@type":"NRID","@value":"9000260215583"},{"@type":"NRID","@value":"9000408486057"},{"@type":"NRID","@value":"9000018564561"},{"@type":"NRID","@value":"9000409787665"},{"@type":"NRID","@value":"9000410166432"},{"@type":"NRID","@value":"9000408635104"},{"@type":"NRID","@value":"9000399780075"},{"@type":"NRID","@value":"9000402241172"},{"@type":"NRID","@value":"9000411389778"},{"@type":"NRID","@value":"9000405895762"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/take-1018"}],"foaf:name":[{"@language":"ja","@value":"川尻 雄大"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"九州大学"}],"role":"co_investigator_buntan"}],"since":"2024-04-01","until":"2027-03-31","institution":[{"institutionIdentifier":[{"@type":"NII","@value":"0017102"}],"notation":[{"@language":"ja","@value":"九州大学"},{"@language":"en","@value":"Kyushu University"}]}],"fundingProgram":[{"jpcoar:funderName":[{"@language":"ja","@value":"科学研究費助成事業"},{"@language":"en","@value":"Grants-in-Aid for Scientific Research"}]},{"funderIdentifier":[{"@type":"CROSSREF","@value":"10.13039/501100001691"}],"jpcoar:funderName":[{"@language":"ja","@value":"科学研究費助成事業"}]}],"url":[{"@id":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K09939/","notation":[{"@value":"KAKEN"}]}],"createdAt":"2024-04-05","modifiedAt":"2025-12-26","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=%E3%81%8C%E3%82%93%E6%82%AA%E6%B6%B2%E8%B3%AA","dc:title":"がん悪液質"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%83%95%E3%82%A7%E3%83%AD%E3%83%88%E3%83%BC%E3%82%B7%E3%82%B9","dc:title":"フェロトーシス"}],"product":[{"@id":"https://cir.nii.ac.jp/crid/1050024953984555136","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"HDL","@value":"https://hdl.handle.net/2324/7393014"}],"notation":[{"@language":"en","@value":"The Effect of Diabetes Medication on the Scores of the GNRI and CONUT Nutritional Indices: Cross-Sectional and Longitudinal Retrospective Studies"}]}],"dataSourceIdentifier":[{"@type":"KAKEN","@value":"24K09939"},{"@type":"IRDB","@value":"oai:irdb.nii.ac.jp:01211:0007009865_KAKEN_KfkvqiSfcSK7T0EcqUV4mo2xH68"}],"grant":{"grantIdentifier":[{"@type":"NII","@value":"72"}],"jpcoar:fundingStream":[{"@language":"ja","@value":"基盤研究(C)"},{"@language":"en","@value":"Grant-in-Aid for Scientific Research (C)"}]},"allocationClassification":[{"notation":[{"@language":"ja","@value":"基金"},{"@language":"en","@value":"Multi-year Fund"}]}],"projectStatus":"granted","allocationAmount":{"totalCost":{"amount":"4550000","currency":"JPY"},"breakdownCost":[{"notation":[{"@language":"ja","@value":"直接経費"},{"@language":"en","@value":"Direct Cost"}],"amount":"3500000","currency":"JPY"},{"notation":[{"@language":"ja","@value":"間接経費"},{"@language":"en","@value":"Indirect Cost"}],"amount":"1050000","currency":"JPY"}]}}