{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1040022457868993920.json","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"25K19737"},{"@type":"JGN","@value":"JP25K19737"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25K19737/"}],"jpcoar:awardTitle":[{"@language":"ja","@value":"食道癌における間質細胞が関与する炎症関連シグナル伝達の解明と新規治療法の開発"},{"@language":"en","@value":"Elucidation of Inflammation-Related Signaling Involving Stromal Cells in Esophageal Cancer and Development of Novel Therapeutic Strategies"}],"field":[{"keyword":[{"language":"ja","textList":["小区分55020:消化器外科学関連"]},{"language":"en","textList":["Basic Section 55020:Digestive surgery-related"]}]}],"dc:language":"ja","description":[{"type":"outline_of_research_initial","notation":[{"@language":"ja","@value":"LIF (Leukemia inhibitory factor)はIL-6ファミリーサイトカインの一つであり、胚細胞、成体細胞で細胞の分化・増殖を調節することが知られている。我々はこれまで、食道扁平上皮癌においてLIFのノックダウンにより食道扁平上皮癌進展が抑制されることを報告した。\n本研究ではLIFやIL-6を標的とした治療を開発し、食道扁平上皮癌の予後改善に取り組むことを目的とする。食堂扁平上皮癌において、LIFが周囲の間質にどのような影響を及ぼすかは明らかではない。これらのクロストークを明らかにすることで、LIFを標的とした治療を臨床応用できると考える。"}]}],"researcher":[{"@id":"https://cir.nii.ac.jp/crid/1420854979951841152","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20932221"},{"@type":"NRID","@value":"1000020932221"}],"foaf:name":[{"@language":"ja","@value":"川副 徹郎"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"九州大学"}],"role":"principal_investigator"}],"since":"2025-04-01","until":"2028-03-31","institution":[{"institutionIdentifier":[{"@type":"NII","@value":"0017102"}],"notation":[{"@language":"ja","@value":"九州大学"},{"@language":"en","@value":"Kyushu University"}]}],"fundingProgram":[{"jpcoar:funderName":[{"@language":"ja","@value":"科学研究費助成事業"},{"@language":"en","@value":"Grants-in-Aid for Scientific Research"}]}],"url":[{"@id":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25K19737/","notation":[{"@value":"KAKEN"}]}],"createdAt":"2025-04-17","modifiedAt":"2025-06-20","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=%E9%A3%9F%E9%81%93%E6%89%81%E5%B9%B3%E4%B8%8A%E7%9A%AE%E7%99%8C","dc:title":"食道扁平上皮癌"}],"dataSourceIdentifier":[{"@type":"KAKEN","@value":"25K19737"}],"grant":{"grantIdentifier":[{"@type":"NII","@value":"252"}],"jpcoar:fundingStream":[{"@language":"ja","@value":"若手研究"},{"@language":"en","@value":"Grant-in-Aid for Early-Career Scientists"}]},"allocationClassification":[{"notation":[{"@language":"ja","@value":"基金"},{"@language":"en","@value":"Multi-year Fund"}]}],"projectStatus":"granted","allocationAmount":{"totalCost":{"amount":"4810000","currency":"JPY"},"breakdownCost":[{"notation":[{"@language":"ja","@value":"直接経費"},{"@language":"en","@value":"Direct Cost"}],"amount":"3700000","currency":"JPY"},{"notation":[{"@language":"ja","@value":"間接経費"},{"@language":"en","@value":"Indirect Cost"}],"amount":"1110000","currency":"JPY"}]}}