{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1040282256701529344.json","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"11470103"},{"@type":"JGN","@value":"JP11470103"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11470103/"}],"jpcoar:awardTitle":[{"@language":"ja","@value":"血中ホモシステインの濃度規定因子の解明と、動脈硬化・循環器疾患発症への関与の分析"},{"@language":"en","@value":"Blood homoysteine, its associated factors, atheroscerosis and cardiovasular desease"}],"field":[{"keyword":[{"language":"ja","textList":["医学","社会医学","公衆衛生学・健康科学"]},{"language":"en","textList":["Medicine","Society medicine","Public health/Health science"]}]}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"ja","@value":"地域住民を対象とする疫学研究により、1)血中ホモシステイン濃度に影響を及ぼす要因の解明、2)血中ホモシステイン濃度と頚動脈硬化との関連の分析、3)長期保存血清を用いて血中ホモシステイン濃度と脳卒中、虚血性心疾患発症との関連のプロスペクティブな分析を行う。\n地域住民における血中ホモシステイン濃度の分布と、その規定因子に関する横断研究として、関東農村の住民40〜74歳男女3,071名と四国人間ドック受診者20〜74歳男女965名について、血漿中のホモシステイン測定を行った。また、関東農村の対象者のうち、514名について、頚動脈エコー検査を実施し頚動脈硬化度を評価した。その結果血中ホモシステイン濃度に影響を及ぼす要因として、年齢、高血圧、肥満度、喫煙以外に、血中葉酸の低値、血中ビタミンB12の低値の関与が認められた。血中ホモシステインの高値と総頚動脈硬化との関連も有意に認められた。血中ホモシステイン濃度に対する血清中の葉酸、B12、B6の影響を遺伝子多型別に検討したところ、ホモシステインが高値を示すMTHFRのVV型の群においても、血清中の葉酸とB12が高いとホモシステインの上昇が抑えられることが確かめられた。\n血中ホモシステイン濃度と循環器疾患の発症に関する追跡調査として、対象4地域の循環器検診受診者40歳以上男女約1万人の血清を3〜10年保存しており、この血清を用いて、その後の循環器疾患の発症者(脳卒中74名、虚血性心疾患28名、)と性、年齢、地域、保存年数をマッチさせた非発症者(1:3の割合で抽出)の間で、血中ホモシステインの濃度を比較した。全脳卒中の発症に関して血清ホモシステイン濃度と有意な関連を認めた。"},{"@language":"en","@value":"We have conducted cross-sectional and prospective nested-case control studies to investigate associated factors for blood homocysteine, the relation between homocysteine and carotid atherosclerosis, and the relation between homocysteine and the risk of stroke and coronary heart disease. The subjects were 3,071 men and women aged 40-79 in Ibaraki rural community and 965 participants aged 20-74 in clinic health examination of Kochi for a cross-sectional study. Associated factors for high blood homocysteine concentrations were low serum concentrations of folate and low vitamin B12 and low dietary intakes of vegetables, seaweed and fish\nAssociated factors for homocysteine were age, hypertension, body mass index, and cigarette smoking. Age-adjusted plasma homocysteine levels were higher for both men and women with the homozygous genotype for the mutation than those who were heterozygous or had no mutation. Elevated homocysteine levels in homozygous genotype was attenuated among persons with higher serum levels of vitamin B12 and folate, but not vitamin B6, and among persons with the combination of lower folate and higher vitamin B12 and of higher folate and higher vitamin B12, split by the median. Thus, elevated homocysteine levels among Japanese with the homozygous genotype for the MTHFR gene mutation can be modified efficiently by dietary supplement of vitamin B12 as well as folate.\nA prospective nested case-control study was conducted using frozen serum samples from 7,450 participants in cardiovascular risk surveys, collected from 1984-1989 for one community and 1989-1992 for the other two communities. We identified 74 incident strokes whose subtypes were confirmed by imaging studies. Three controls per case were selected by matching for sex, age, community, year of serum storage and fasting status. The multivariate odds ratio of total stroke for highest vs lowest quartiles of serum homocysteine was 2.6 (1.0, 6.6), P = 0.04. We found that high homocystens predicted the risk of total stroke among 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