Cell-cell comunication in developing skeletal muscle

KAKEN

About This Project

Japan Grant Number
JP16H02585 (JGN)
Funding Program
Grants-in-Aid for Scientific Research
Funding Organization
Japan Society for the Promotion of Science

Kakenhi Information

Project/Area Number
16H02585
Research Category
Grant-in-Aid for Scientific Research (A)
Allocation Type
  • Single-year Grants
Review Section / Research Field
  • Biological Sciences > Agriculture > Animal life science > Animal production science
Research Institution
  • Hokkaido University
Project Period (FY)
2016-04-01 〜 2019-03-31
Project Status
Completed
Budget Amount*help
40,560,000 Yen (Direct Cost: 31,200,000 Yen Indirect Cost: 9,360,000 Yen)

Research Abstract

In order to elucidate the regulatory mechanism of muscle hypertrophy and intramuscular fat accumulation, we investigated the cell-cell communication in skeletal muscle. 1. We found that exosomes secreted by muscle cells and adipocytes were taken up into heterologous cells and affected the gene expression of the cells that took up exosomes. 2. Adipocytes suppress the differentiation of muscle cells and promote muscle atrophy by inducing the expression and secretion of IL-6 in muscle cells. 3. We show that APOBEC2 suppresses the pathway in which differentiated satellite cells fuse to form myotubes and promote self-renewal during muscle regeneration. 4. TGF-b1 has been shown to exert potent inhibitory effects at the early stages of muscle regeneration and lipogenesis.

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