{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1040282256873099648.json","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"16H02585"},{"@type":"JGN","@value":"JP16H02585"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H02585/"}],"jpcoar:awardTitle":[{"@language":"ja","@value":"骨格筋発達の統合的理解を目指す異種細胞間コミュニケーション機構の全容解明"},{"@language":"en","@value":"Cell-cell comunication in developing skeletal muscle"}],"field":[{"keyword":[{"language":"ja","textList":["生物系","農学","動物生命科学","動物生産科学"]},{"language":"en","textList":["Biological Sciences","Agriculture","Animal life science","Animal production science"]}]}],"dc:language":"ja","description":[{"type":"outline_of_research_achievement","notation":[{"@language":"ja","@value":"筋肥大と脂肪蓄積の制御機構を解明するため、骨格筋内の異種細胞間コミュニケーション機構を追究した。1.筋細胞および脂肪細胞が分泌するエクソソームが異種細胞へ取り込まれ、エクソソームを取り込んだ細胞の遺伝子発現に影響を及ぼすことを実証した。2.脂肪細胞は筋細胞におけるIL-6の発現および分泌を誘導することで、分化を抑制するとともに筋萎縮を促進していることを明らかにした。3. 筋再生時にAPOBEC2は、分化した衛星細胞が融合し筋管を形成するパスウェイを抑制しセルフリニューアルを促進することを明らかにした。4. TGF-b1は、筋再生や脂肪形成の初期段階で強力に抑制効果を発揮することが明らかにした。"},{"@language":"en","@value":"In order to elucidate the regulatory mechanism of muscle hypertrophy and intramuscular fat accumulation, we investigated the cell-cell communication in skeletal muscle. 1. We found that exosomes secreted by muscle cells and adipocytes were taken up into heterologous cells and affected the gene expression of the cells that took up exosomes. 2. Adipocytes suppress the differentiation of muscle cells and promote muscle atrophy by inducing the expression and secretion of IL-6 in muscle cells. 3. We show that APOBEC2 suppresses the pathway in which differentiated satellite cells fuse to form myotubes and promote self-renewal during muscle regeneration. 4. TGF-b1 has been shown to exert potent inhibitory effects at the early stages of muscle regeneration and lipogenesis."}]},{"type":"significance_of_research_achievement","notation":[{"@language":"ja","@value":"家畜骨格筋における筋肥大（赤肉生産）と筋肉内脂肪蓄積（霜降り肉生産）の制御機構について、骨格筋内の細胞群（筋細胞、脂肪細胞、神経細胞およびマクロファージ）とコミュニケーションの場である細胞外マトリックスに着目し、分泌性生理活性因子およびエクソソーム（細胞間でタンパク質およびmicroRNA を運搬する小胞）を介した異種細胞間のローカルなコミュニケーションとその制御機構を解明する。これにより、肉用家畜生産における肉量・肉質制御技術開発のための細胞分子基盤を確立する。"}]}],"researcher":[{"@id":"https://cir.nii.ac.jp/crid/1420001326205837824","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10237729"},{"@type":"NRID","@value":"1000010237729"},{"@type":"NRID","@value":"9000019087684"},{"@type":"NRID","@value":"9000002451085"},{"@type":"NRID","@value":"9000391636441"},{"@type":"NRID","@value":"9000414207720"},{"@type":"NRID","@value":"9000413947000"},{"@type":"NRID","@value":"9000324992997"},{"@type":"NRID","@value":"9000414207005"},{"@type":"NRID","@value":"9000398292742"},{"@type":"NRID","@value":"9000283497640"},{"@type":"NRID","@value":"9000414208451"},{"@type":"NRID","@value":"9000414206992"},{"@type":"NRID","@value":"9000411772492"},{"@type":"NRID","@value":"9000253163828"},{"@type":"NRID","@value":"9000414207020"},{"@type":"NRID","@value":"9000018562899"},{"@type":"NRID","@value":"9000405858399"},{"@type":"NRID","@value":"9000397426550"},{"@type":"NRID","@value":"9000412058001"},{"@type":"NRID","@value":"9000243889420"},{"@type":"NRID","@value":"9000414207733"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/decorin"}],"foaf:name":[{"@language":"ja","@value":"西邑 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