{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1040282256904552192.json","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"16K21751"},{"@type":"JGN","@value":"JP16K21751"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K21751/"}],"jpcoar:awardTitle":[{"@language":"ja","@value":"遺伝子改変制御性Ｔ細胞を用いた炎症性疾患治療の実現を目指した基礎的検討"},{"@language":"en","@value":"A basic research aimed at realizing the treatment of inflammatory diseases using engineered Treg cells"}],"field":[{"keyword":[{"language":"ja","textList":["生物系","医歯薬学","内科系臨床医学","膠原病・アレルギー内科学"]},{"language":"en","textList":["Biological Sciences","Medicine, Dentistry, and Pharmacy","Clinical internal medicine","Collagenous pathology/Allergology"]}]}],"dc:language":"ja","description":[{"type":"outline_of_research_achievement","notation":[{"@language":"ja","@value":"制御性T細胞（regulatory T cells; Treg）は、免疫応答のブレーキ役、調節役として機能するが、この細胞による免疫抑制の基本的な動作メカニズムの全容は未だ解明されていない。本研究では、制御性T細胞上の抗原受容体に着目し、この受容体が果たす役割の解明を目指し、研究を行った。また、この受容体に人為的な改変を加えた、遺伝子改変制御性T細胞を作製し、炎症治療に用いる事ができるかについての検討も行った。"},{"@language":"en","@value":"Regulatory T cells (Treg) function as modulators of immune responses. The basic mechanism of immunosuppression by these cells has not yet been fully elucidated. In this study, we focused on antigenic receptors on regulatory T cells to elucidate the role of these receptors. We also generated genetically engineered regulatory T cells by artificially modifying the receptor and examined whether they could be used for the treatment of inflammatory disorders."}]},{"type":"significance_of_research_achievement","notation":[{"@language":"ja","@value":"炎症の行き過ぎに起因する様々な難治性疾患に対する新規治療法の一つとして、制御性T細胞の持つこの抑制能を活用する事が期待されているが、それを実現する為には、この細胞による免疫抑制の基本的な動作メカニズムを詳細に解明する必要がある。本研究では、制御性T細胞上に発現する抗原受容体の役割を解明すべく研究を行った。制御性T細胞を用いた炎症性疾患治療を実現するにあたり不可欠な有用な知見が得られた。"}]}],"researcher":[{"@id":"https://cir.nii.ac.jp/crid/1420564276167356544","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80432912"},{"@type":"NRID","@value":"1000080432912"},{"@type":"NRID","@value":"9000002128150"},{"@type":"NRID","@value":"9000410466092"},{"@type":"NRID","@value":"9000408495334"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/chinent"}],"foaf:name":[{"@language":"ja","@value":"知念 孝敏"},{"@language":"en","@value":"Chinen Takatoshi"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"九州大学"}],"role":"principal_investigator"}],"since":"2018-04-01","until":"2022-03-31","institution":[{"institutionIdentifier":[{"@type":"NII","@value":"0017102"}],"notation":[{"@language":"ja","@value":"九州大学"},{"@language":"en","@value":"Kyushu University"}]}],"fundingProgram":[{"jpcoar:funderName":[{"@language":"ja","@value":"科学研究費助成事業"},{"@language":"en","@value":"Grants-in-Aid for Scientific 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