{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1040282256991347712.json","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"19H03316"},{"@type":"JGN","@value":"JP19H03316"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H03316/"}],"jpcoar:awardTitle":[{"@language":"ja","@value":"メラトニン受容体の遺伝子多型と夜勤時の光の生体影響"},{"@language":"en","@value":"Association between genetic polymorphisms of melatonin receptor and psycho-physiological effects of simulated night shift work"}],"field":[{"keyword":[{"language":"ja","textList":["小区分45060:応用人類学関連"]},{"language":"en","textList":["Basic Section 45060:Applied anthropology-related"]}]}],"dc:language":"ja","description":[{"type":"outline_of_research_initial","notation":[{"@language":"ja","@value":"不規則な生活が強いられる夜勤・交代制勤務への従事は、睡眠障害や生活習慣病のリスクを高める。ゲノムワイド関連研究においてメラトニン受容体遺伝子の近傍にある一塩基多型が交代制勤務者の疲弊度と関連があることが明らかにされている。しかし、この遺伝子多型が夜勤にともなう光曝露などによって生じる概日リズムの位相後退やメラトニン分泌の抑制および、断眠によって生じる眠気の増加やパフォーマンスの低下とどの程度関連するかは不明である。そこで、本研究では、実験室にて光曝露を伴う模擬的な夜勤実験を実施し、メラトニン受容体遺伝子に関連する遺伝子多型と夜勤への適応度の関連について明らかにする。"}]}],"researcher":[{"@id":"https://cir.nii.ac.jp/crid/1420845751139614592","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"40401228"},{"@type":"NRID","@value":"1000040401228"},{"@type":"ORCID","@value":"0000-0003-0746-2729"},{"@type":"CINII_AUTHOR_ID","@value":"DA17922847"},{"@type":"URI","@value":"https://ci.nii.ac.jp/author/DA17922847#entity"},{"@type":"URI","@value":"https://viaf.org/viaf/NII%7CDA17922847"},{"@type":"NRID","@value":"9000248221601"},{"@type":"NRID","@value":"9000391518567"},{"@type":"NRID","@value":"9000237760122"},{"@type":"NRID","@value":"9000022852692"},{"@type":"NRID","@value":"9000250183093"},{"@type":"NRID","@value":"9000409467809"},{"@type":"NRID","@value":"9000412173425"},{"@type":"NRID","@value":"9000414491090"},{"@type":"NRID","@value":"9000410615175"},{"@type":"NRID","@value":"9000007646404"},{"@type":"NRID","@value":"9000414354369"},{"@type":"NRID","@value":"9000410507451"},{"@type":"NRID","@value":"9000248221719"},{"@type":"NRID","@value":"9000414354341"},{"@type":"NRID","@value":"9000410507560"},{"@type":"NRID","@value":"9000403599468"},{"@type":"NRID","@value":"9000019188745"},{"@type":"NRID","@value":"9000410507479"},{"@type":"NRID","@value":"9000414944050"},{"@type":"NRID","@value":"9000408895501"},{"@type":"NRID","@value":"9000345442144"},{"@type":"NRID","@value":"9000002056215"},{"@type":"NRID","@value":"9000411814073"},{"@type":"NRID","@value":"9000347149946"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/genome-anthropology"}],"foaf:name":[{"@language":"ja","@value":"太田 博樹"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"東京大学"}],"role":"co_investigator_buntan"},{"@id":"https://cir.nii.ac.jp/crid/1420564276180456576","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00292376"},{"@type":"NRID","@value":"1000000292376"},{"@type":"NRID","@value":"9000003849898"},{"@type":"NRID","@value":"9000003849776"},{"@type":"NRID","@value":"9000414497821"},{"@type":"NRID","@value":"9000006342192"},{"@type":"NRID","@value":"9000386229009"},{"@type":"NRID","@value":"9000396147218"},{"@type":"NRID","@value":"9000003831239"},{"@type":"NRID","@value":"9000003852868"},{"@type":"NRID","@value":"9000319553669"},{"@type":"NRID","@value":"9000003853595"},{"@type":"NRID","@value":"9000410507450"},{"@type":"NRID","@value":"9000412336177"},{"@type":"NRID","@value":"9000403599467"},{"@type":"NRID","@value":"9000018468639"},{"@type":"NRID","@value":"9000003828999"},{"@type":"NRID","@value":"9000003831234"},{"@type":"NRID","@value":"9000242892062"},{"@type":"NRID","@value":"9000019019987"},{"@type":"NRID","@value":"9000003829970"},{"@type":"NRID","@value":"9000398394677"},{"@type":"NRID","@value":"9000003829073"},{"@type":"NRID","@value":"9000402100583"},{"@type":"NRID","@value":"9000242891923"},{"@type":"NRID","@value":"9000411537104"},{"@type":"NRID","@value":"9000398618953"},{"@type":"NRID","@value":"9000003865368"},{"@type":"NRID","@value":"9000004559866"},{"@type":"NRID","@value":"9000413542787"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0188750"}],"foaf:name":[{"@language":"ja","@value":"樋口 重和"},{"@language":"en","@value":"HIGUCHI SHIGEKAZU"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"九州大学"}],"role":"principal_investigator"},{"@id":"https://cir.nii.ac.jp/crid/1420282801190972160","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80713148"},{"@type":"NRID","@value":"1000080713148"},{"@type":"NRID","@value":"9000014595004"},{"@type":"NRID","@value":"9000411775215"},{"@type":"NRID","@value":"9000411814630"},{"@type":"NRID","@value":"9000411813386"},{"@type":"NRID","@value":"9000411811870"},{"@type":"NRID","@value":"9000242892023"},{"@type":"NRID","@value":"9000411819941"},{"@type":"NRID","@value":"9000394470587"},{"@type":"NRID","@value":"9000411815322"},{"@type":"NRID","@value":"9000411821792"},{"@type":"NRID","@value":"9000411812175"},{"@type":"NRID","@value":"9000403273985"},{"@type":"NRID","@value":"9000411813256"},{"@type":"NRID","@value":"9000411806245"},{"@type":"NRID","@value":"9000412099712"},{"@type":"NRID","@value":"9000399499269"},{"@type":"NRID","@value":"9000411809931"},{"@type":"NRID","@value":"9000376944569"},{"@type":"NRID","@value":"9000411814159"},{"@type":"NRID","@value":"9000411817832"},{"@type":"NRID","@value":"9000019085578"},{"@type":"NRID","@value":"9000411811835"},{"@type":"NRID","@value":"9000411814070"},{"@type":"NRID","@value":"9000399499223"},{"@type":"NRID","@value":"9000020566647"},{"@type":"NRID","@value":"9000411812020"},{"@type":"NRID","@value":"9000412104663"},{"@type":"NRID","@value":"9000242891943"},{"@type":"NRID","@value":"9000403314399"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/taka0613"}],"foaf:name":[{"@language":"ja","@value":"西村 貴孝"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"九州大学"}],"role":"co_investigator_buntan"}],"since":"2019-04-01","until":"2022-03-31","institution":[{"institutionIdentifier":[{"@type":"NII","@value":"0017102"}],"notation":[{"@language":"ja","@value":"九州大学"},{"@language":"en","@value":"Kyushu University"}]}],"fundingProgram":[{"jpcoar:funderName":[{"@language":"ja","@value":"科学研究費助成事業"},{"@language":"en","@value":"Grants-in-Aid for Scientific Research"}]}],"url":[{"@id":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H03316/","notation":[{"@value":"KAKEN"}]}],"createdAt":"2019-04-18","modifiedAt":"2025-11-20","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=%E6%A6%82%E6%97%A5%E3%83%AA%E3%82%BA%E3%83%A0","dc:title":"概日リズム"},{"@id":"https://cir.nii.ac.jp/all?q=%E4%BA%A4%E4%BB%A3%E5%88%B6%E5%8B%A4%E5%8B%99","dc:title":"交代制勤務"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%83%A1%E3%83%A9%E3%83%88%E3%83%8B%E3%83%B3%E5%8F%97%E5%AE%B9%E4%BD%93%E9%81%BA%E4%BC%9D%E5%AD%90","dc:title":"メラトニン受容体遺伝子"},{"@id":"https://cir.nii.ac.jp/all?q=%E4%B8%80%E5%A1%A9%E5%9F%BA%E5%A4%9A%E5%9E%8B","dc:title":"一塩基多型"},{"@id":"https://cir.nii.ac.jp/all?q=%E7%92%B0%E5%A2%83%E9%81%A9%E5%BF%9C","dc:title":"環境適応"},{"@id":"https://cir.nii.ac.jp/all?q=%E5%85%89%E7%92%B0%E5%A2%83","dc:title":"光環境"},{"@id":"https://cir.nii.ac.jp/all?q=%E5%A4%9C%E5%8B%A4%E3%83%BB%E4%BA%A4%E4%BB%A3%E5%88%B6%E5%8B%A4%E5%8B%99","dc:title":"夜勤・交代制勤務"},{"@id":"https://cir.nii.ac.jp/all?q=%E7%9D%A1%E7%9C%A0","dc:title":"睡眠"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%83%A1%E3%83%A9%E3%83%88%E3%83%8B%E3%83%B3%E5%8F%97%E5%AE%B9%E4%BD%93","dc:title":"メラトニン受容体"},{"@id":"https://cir.nii.ac.jp/all?q=%E9%81%BA%E4%BC%9D%E5%AD%90%E5%A4%9A%E5%9E%8B","dc:title":"遺伝子多型"}],"product":[{"@id":"https://cir.nii.ac.jp/crid/1390571704643407232","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"DOI","@value":"10.2486/indhealth.2020-0245"},{"@type":"PMID","@value":"34588379"},{"@type":"NDL_BIB_ID","@value":"031854571"},{"@type":"NDL_CALL_NUMBER","@value":"Z51-F156"},{"@type":"URI","@value":"http://id.ndl.go.jp/bib/031854571"},{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I031854571"},{"@type":"URI","@value":"https://www.jstage.jst.go.jp/article/indhealth/59/6/59_2020-0245/_pdf"},{"@type":"HANDLE","@value":"2115/83779"},{"@type":"HDL","@value":"https://hdl.handle.net/2115/83779"},{"@type":"NAID","@value":"130008121523"},{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2022266981"}],"notation":[{"@language":"en","@value":"Effects of 2-hour nighttime nap on melatonin concentration and alertness during 12-hour simulated night work"}]},{"@id":"https://cir.nii.ac.jp/crid/1360576118739796736","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"DOI","@value":"10.1186/s40101-021-00257-x"},{"@type":"URI","@value":"https://link.springer.com/content/pdf/10.1186/s40101-021-00257-x.pdf"},{"@type":"URI","@value":"https://link.springer.com/article/10.1186/s40101-021-00257-x/fulltext.html"},{"@type":"PMID","@value":"34103077"},{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2022122782"}],"notation":[{"@value":"Is the use of high correlated color temperature light at night related to delay of sleep timing in university students? A cross-country study in Japan and China"}]},{"@id":"https://cir.nii.ac.jp/crid/1010294643569896578","@type":"Article","resourceType":"学術雑誌論文(journal article)","notation":[{"@language":"ja","@value":"ipRGCの発見と概日リズム研究の発展"}]},{"@id":"https://cir.nii.ac.jp/crid/1010857593585974531","@type":"Article","resourceType":"学術雑誌論文(journal article)","notation":[{"@language":"ja","@value":"メラノプシン神経節細胞の光符号化に関する研究調査委員会報告書"}]},{"@id":"https://cir.nii.ac.jp/crid/1050869456404848768","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"HDL","@value":"https://hdl.handle.net/2115/81619"},{"@type":"DOI","@value":"10.1080/07420528.2020.1752704"},{"@type":"URI","@value":"https://www.tandfonline.com/doi/pdf/10.1080/07420528.2020.1752704"},{"@type":"PMID","@value":"32326827"},{"@type":"HANDLE","@value":"2115/81619"},{"@type":"NAID","@value":"120007042010"}],"notation":[{"@language":"en","@value":"Melatonin suppression during a simulated night shift in medium intensity light is increased by 10-minute breaks in dim light and decreased by 10-minute breaks in bright light"}]},{"@id":"https://cir.nii.ac.jp/crid/1360584341816213504","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"DOI","@value":"10.1186/s40101-023-00328-1"},{"@type":"URI","@value":"https://link.springer.com/content/pdf/10.1186/s40101-023-00328-1.pdf"},{"@type":"URI","@value":"https://link.springer.com/article/10.1186/s40101-023-00328-1/fulltext.html"},{"@type":"PMID","@value":"37355647"}],"notation":[{"@value":"Review on age-related differences in non-visual effects of light: melatonin suppression, circadian phase shift and pupillary light reflex in children to older adults"}]},{"@id":"https://cir.nii.ac.jp/crid/1360584339758894208","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"DOI","@value":"10.3390/clockssleep5040041"},{"@type":"URI","@value":"https://www.mdpi.com/2624-5175/5/4/41/pdf"},{"@type":"PMID","@value":"37873842"}],"notation":[{"@value":"Relationship between Circadian Phase Delay without Morning Light and Phase Advance by Bright Light Exposure the Following Morning"}]},{"@id":"https://cir.nii.ac.jp/crid/1971149384751114761","@type":"Book","resourceType":"図書(book)","productIdentifier":[{"@type":"NCID","@value":"BC03815552"},{"@type":"ISBN","@value":"9784254301205"},{"@type":"URI","@value":"https://ci.nii.ac.jp/ncid/BC03815552#entity"},{"@type":"URI","@value":"https://elib.maruzen.co.jp/elib/html/BookDetail/Id/3000107136"},{"@type":"URI","@value":"https://kinoden.kinokuniya.co.jp/user/bookdetail/p/KP00049419"},{"@type":"URI","@value":"https://mol.medicalonline.jp/library/ebooks/detail?id=13266"}],"notation":[{"@language":"ja","@value":"睡眠学"},{"@language":"ja-Kana","@value":"スイミンガク"}]},{"@id":"https://cir.nii.ac.jp/crid/1971430859835503415","@type":"Book","resourceType":"図書(book)","productIdentifier":[{"@type":"NCID","@value":"BC0450627X"},{"@type":"ISBN","@value":"9784844609025"},{"@type":"URI","@value":"https://ci.nii.ac.jp/ncid/BC0450627X#entity"},{"@type":"URI","@value":"https://elib.maruzen.co.jp/elib/html/BookDetail/Id/3000164273"}],"notation":[{"@language":"ja","@value":"生理人類学 : 人の理解と日常の課題発見のために"},{"@language":"ja-Kana","@value":"セイリ ジンルイガク : ヒト ノ リカイ ト ニチジョウ ノ カダイ ハッケン ノ タメ ニ"}]}],"dataSourceIdentifier":[{"@type":"KAKEN","@value":"19H03316"}],"grant":{"grantIdentifier":[{"@type":"NII","@value":"69"}],"jpcoar:fundingStream":[{"@language":"ja","@value":"基盤研究(B)"},{"@language":"en","@value":"Grant-in-Aid for Scientific Research (B)"}]},"allocationClassification":[{"notation":[{"@language":"ja","@value":"補助金"},{"@language":"en","@value":"Single-year Grants"}]}],"projectStatus":"project_closed","allocationAmount":{"totalCost":{"amount":"17290000","currency":"JPY"},"breakdownCost":[{"notation":[{"@language":"ja","@value":"直接経費"},{"@language":"en","@value":"Direct Cost"}],"amount":"13300000","currency":"JPY"},{"notation":[{"@language":"ja","@value":"間接経費"},{"@language":"en","@value":"Indirect Cost"}],"amount":"3990000","currency":"JPY"}]}}