{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1040282256999761792.json","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"19K16837"},{"@type":"JGN","@value":"JP19K16837"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K16837/"}],"jpcoar:awardTitle":[{"@language":"ja","@value":"ポリオウイルスレセプターを標的とした非小細胞肺癌に対する新規複合免疫療法の開発"},{"@language":"en","@value":"Novel Combination Immunotherapy for Non-Small Cell Lung Cancer Targeting Poliovirus Receptor"}],"field":[{"keyword":[{"language":"ja","textList":["小区分50020:腫瘍診断および治療学関連"]},{"language":"en","textList":["Basic Section 50020:Tumor diagnostics and therapeutics-related"]}]}],"dc:language":"ja","description":[{"type":"outline_of_research_initial","notation":[{"@language":"ja","@value":"①　非小細胞肺癌切除検体におけるCD155発現を解析し、臨床病理学的因子、PD-L1発現、腫瘍浸潤リンパ球、遺伝子解析結果（EGFR、ALK）、予後との関係を明らかにする。②　EGFRやALKの遺伝子変異を有する肺癌細胞株を用いて、CD155発現誘導機序においてdriver oncogeneが関与しているかを検討する。③　ルイス肺癌マウスモデルを用いて、CD155およびPD-L1の両者を標的とした新規複合免疫療法の抗腫瘍効果を検証し、治療モデルを確立する。"}]}],"researcher":[{"@id":"https://cir.nii.ac.jp/crid/1420001326211057664","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50806495"},{"@type":"NRID","@value":"1000050806495"}],"foaf:name":[{"@language":"ja","@value":"高田 和樹"},{"@language":"en","@value":"TAKADA Kazuki"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"九州大学"}],"role":"principal_investigator"}],"since":"2019-04-01","until":"2023-03-31","institution":[{"institutionIdentifier":[{"@type":"NII","@value":"0017102"}],"notation":[{"@language":"ja","@value":"九州大学"},{"@language":"en","@value":"Kyushu University"}]}],"fundingProgram":[{"jpcoar:funderName":[{"@language":"ja","@value":"科学研究費助成事業"},{"@language":"en","@value":"Grants-in-Aid for Scientific Research"}]}],"url":[{"@id":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K16837/","notation":[{"@value":"KAKEN"}]}],"createdAt":"2019-04-18","modifiedAt":"2025-11-20","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=%E9%9D%9E%E5%B0%8F%E7%B4%B0%E8%83%9E%E8%82%BA%E7%99%8C","dc:title":"非小細胞肺癌"},{"@id":"https://cir.nii.ac.jp/all?q=%E5%85%8D%E7%96%AB%E7%99%82%E6%B3%95","dc:title":"免疫療法"},{"@id":"https://cir.nii.ac.jp/all?q=%E4%BA%88%E5%BE%8C%E5%9B%A0%E5%AD%90","dc:title":"予後因子"},{"@id":"https://cir.nii.ac.jp/all?q=%E8%82%BA%E8%85%BA%E7%99%8C","dc:title":"肺腺癌"},{"@id":"https://cir.nii.ac.jp/all?q=%E8%82%BA%E6%89%81%E5%B9%B3%E4%B8%8A%E7%9A%AE%E7%99%8C","dc:title":"肺扁平上皮癌"},{"@id":"https://cir.nii.ac.jp/all?q=CD155","dc:title":"CD155"},{"@id":"https://cir.nii.ac.jp/all?q=PD-L1","dc:title":"PD-L1"},{"@id":"https://cir.nii.ac.jp/all?q=EGFR","dc:title":"EGFR"},{"@id":"https://cir.nii.ac.jp/all?q=%E4%BA%88%E5%BE%8C","dc:title":"予後"},{"@id":"https://cir.nii.ac.jp/all?q=PD-L2","dc:title":"PD-L2"},{"@id":"https://cir.nii.ac.jp/all?q=TIGIT","dc:title":"TIGIT"},{"@id":"https://cir.nii.ac.jp/all?q=lung%20cancer","dc:title":"lung cancer"}],"dataSourceIdentifier":[{"@type":"KAKEN","@value":"19K16837"}],"grant":{"grantIdentifier":[{"@type":"NII","@value":"252"}],"jpcoar:fundingStream":[{"@language":"ja","@value":"若手研究"},{"@language":"en","@value":"Grant-in-Aid for Early-Career Scientists"}]},"allocationClassification":[{"notation":[{"@language":"ja","@value":"基金"},{"@language":"en","@value":"Multi-year Fund"}]}],"projectStatus":"project_closed","allocationAmount":{"totalCost":{"amount":"4290000","currency":"JPY"},"breakdownCost":[{"notation":[{"@language":"ja","@value":"直接経費"},{"@language":"en","@value":"Direct Cost"}],"amount":"3300000","currency":"JPY"},{"notation":[{"@language":"ja","@value":"間接経費"},{"@language":"en","@value":"Indirect Cost"}],"amount":"990000","currency":"JPY"}]}}