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Identification and functional analysis of sugar chains involved in bone differentiation of mesenchymal stem cells, and bone regeneration
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- HOSAKA Yoshinao
- Principal Investigator
- Tottori University
About This Project
- Japan Grant Number
- JP21780265 (JGN)
- Funding Program
- Grants-in-Aid for Scientific Research
- Funding Organization
- Japan Society for the Promotion of Science
Kakenhi Information
- Project/Area Number
- 21780265
- Research Category
- Grant-in-Aid for Young Scientists (B)
- Allocation Type
-
- Single-year Grants
- Review Section / Research Field
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- Biological Sciences > Agriculture > Zootechnical science/Veterinary medical science > Basic veterinary science/Basic zootechnical science
- Research Institution
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- Tottori University
- Project Period (FY)
- 2009 〜 2010
- Project Status
- Completed
- Budget Amount*help
- 4,550,000 Yen (Direct Cost: 3,500,000 Yen Indirect Cost: 1,050,000 Yen)
Research Abstract
In this study, we identified CS/DS sugar chain, which closely related to bone differentiation, and then analyzed its functions. Experiments using cultured cells, five types CS/DS (CS-A, -B, -C, -D and -E) chain were compared the ALP activity and calcium deposition and resulted CS-E had the strongest ability to induce bone differentiation. The CS-E-containing sponges (2ug/defect) were implanted in the site of bone defects created in Wistar rat skull, the bone regeneration was confirmed. The rate of bone regeneration in a 15-week experimental period was approximately 30% of defects.