Trans-generational"memory" in Drosophila innate immunity

KAKEN

About This Project

Japan Grant Number
JP21890009 (JGN)
Funding Program
Grants-in-Aid for Scientific Research
Funding Organization
Japan Society for the Promotion of Science

Kakenhi Information

Project/Area Number
21890009
Research Category
Grant-in-Aid for Research Activity Start-up
Allocation Type
  • Single-year Grants
Review Section / Research Field
  • Biological Sciences > Medicine, Dentistry, and Pharmacy > Pharmacy > Biological pharmacy
Research Institution
  • Tohoku University
Project Period (FY)
2009 〜 2010
Project Status
Completed
Budget Amount*help
2,652,000 Yen (Direct Cost: 2,040,000 Yen Indirect Cost: 612,000 Yen)

Research Abstract

To examine the existence of"trans-generational memory" in innate immunity, we used Drosophila melanogaster as a model system and did generational infection experiments. Gene expression profiling analyses revealed that some innate immunity-related gene expression patterns in response to a bacteria infection is significantly different between test group that has been infected at previous generations and the control group not infected previously. The results suggest the possibility that organism which only has innate immunity can"memorize" environmental stress, and that the"memory" can be maintained across generations.

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