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Identification and analysis of chondroitin sulfates which regulate bone remodeling, and control of bone mass
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- HOSAKA Yoshinao
- Principal Investigator
- 鳥取大学
About This Project
- Japan Grant Number
- JP23780293 (JGN)
- Funding Program
- Grants-in-Aid for Scientific Research
- Funding Organization
- Japan Society for the Promotion of Science
Kakenhi Information
- Project/Area Number
- 23780293
- Research Category
- Grant-in-Aid for Young Scientists (B)
- Allocation Type
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- Multi-year Fund
- Review Section / Research Field
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- Biological Sciences > Agriculture > Zootechnical science/Veterinary medical science > Basic veterinary science/Basic zootechnical science
- Research Institution
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- Tottori University
- Project Period (FY)
- 2011 〜 2013
- Project Status
- Completed
- Budget Amount*help
- 4,420,000 Yen (Direct Cost: 3,400,000 Yen Indirect Cost: 1,020,000 Yen)
Research Abstract
In present study, I investigated the osteoclast inhibition ability in CS and the mechanism how CS inhibit osteoclast differentiation in vitro. CS was significantly inhibited the number of tartrate-resistance acid phosphatase (TRAP)-positive multinucleated cells and bone resorption activity in pit formation assay.In quartz-crystal microbalance method, CS revealed the binding ability to RANKL and interrupted binding of RANK to RANKL. Furthermore, CS reduced the phosphorylation of extracellular ERK in pre-osteoclast cells. These results indicate that CS suppress osteoclast size and osteoclastogenesis by binding to RANKL and inhibited RANK signal pathway.
Keywords
Details 詳細情報について
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- CRID
- 1040282257161201024
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- Text Lang
- ja
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- Data Source
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- KAKEN