Functional analysis of epigenetic regulation in Drosophilaintestinal homeostasis

KAKEN

About This Project

Japan Grant Number
JP23790073 (JGN)
Funding Program
Grants-in-Aid for Scientific Research
Funding Organization
Japan Society for the Promotion of Science

Kakenhi Information

Project/Area Number
23790073
Research Category
Grant-in-Aid for Young Scientists (B)
Allocation Type
  • Multi-year Fund
Review Section / Research Field
  • Biological Sciences > Medicine, Dentistry, and Pharmacy > Pharmacy > Biological pharmacy
Research Institution
  • Tohoku University
Project Period (FY)
2011 〜 2012
Project Status
Completed
Budget Amount*help
4,290,000 Yen (Direct Cost: 3,300,000 Yen Indirect Cost: 990,000 Yen)

Research Abstract

To identify novel, evolutionally conserved epigenetic mechanisms that regulate gut immunity or homeostasis, we explored chromatin modifiers involved in intestinal pathology using the Drosophila model system. We found that forced removal of histone H3 lysine36 methylation (H3K36me) in intestinal stem cell (ISC)/enteroblast (EB) increases the resistance to Pseudomonas aeruginosa infection. However, further analyses indicated that the forced H3K36me demethylation in ISC/EB causes over-activation of oxidative stress response genes and shortens lifespan. These results suggest that H3K36me might contribute to appropriate regulation of stress responses and/or the maintenance of homeostasis in Drosophila intestine.

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