Cell-cell communications in developing skeletal muscle

KAKEN

About This Project

Japan Grant Number
JP24248045 (JGN)
Funding Program
Grants-in-Aid for Scientific Research
Funding Organization
Japan Society for the Promotion of Science

Kakenhi Information

Project/Area Number
24248045
Research Category
Grant-in-Aid for Scientific Research (A)
Allocation Type
  • Single-year Grants
Review Section / Research Field
  • Biological Sciences > Agriculture > Zootechnical science/Veterinary medical science > Zootechnical science/Grassland science
Research Institution
  • Hokkaido University
Project Period (FY)
2012-04-01 〜 2015-03-31
Project Status
Completed
Budget Amount*help
43,420,000 Yen (Direct Cost: 33,400,000 Yen Indirect Cost: 10,020,000 Yen)

Research Abstract

As skeletal muscle tissue consists of not only muscle cells but also other types of cells, including nerve cells and fat cells, the formation of skeletal muscle must be precisely regulated by these types of cells. Thus, we investigated the mechanisms of cell-cell communications in skeletal muscle. Myogenic cells secreted more than 400 proteins and approximately 8% of them were categorized as myokines. The levels of myokines that promote myotube formation peaked during early differentiation, whereas myokines contributing to repellent activity against nerve cells or suppression of adipogenesis decreased after differentiation. Myostatin secreted from myotubes suppressed the lipid accumulation in adipocytes. Some extracellular molecules modulated the action of myostatin to adipocytes. Satellite cells, resident myogenic stem cells, controlled neuritogenesis by up-regulating a secreted neural chemorepellent semaphorin 3A, which were induced by HGF that was secreted from macrophages.

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