Analysis of molecular mechanisms involved in the susceptibility to statins on cancer cells

KAKEN

About This Project

Japan Grant Number
JP26890019 (JGN)
Funding Program
Grants-in-Aid for Scientific Research
Funding Organization
Japan Society for the Promotion of Science

Kakenhi Information

Project/Area Number
26890019
Research Category
Grant-in-Aid for Research Activity Start-up
Allocation Type
  • Single-year Grants
Review Section / Research Field
  • Biological Sciences > Biological Sciences > Oncology > Tumor diagnostics
Research Institution
  • Tottori University
Project Period (FY)
2014-08-29 〜 2016-03-31
Project Status
Completed
Budget Amount*help
2,730,000 Yen (Direct Cost: 2,100,000 Yen Indirect Cost: 630,000 Yen)

Research Abstract

The anti-proliferative effect of stains on cancer cells has received widespread attention, since it has been reported that the statins may exhibit an anti-cancer effect in addition to their cholesterol-lowering effect. However, what type of cancer cell statin is effective for is unclear. Our previous study identified E-cadherin as a candidate factor determining the susceptibility to statin. To demonstrate that E-cadherin actually determines the susceptibility of cancer cells to statin, we examined if the regulation of E-cadherin expression has an influence on the susceptibility of cancer cells to statin in the present study. When E-cadherin gene (CDH1) was inserted into the statin-sensitive cells which had no E-cadherin, the half maximal inhibitory concentration (IC50) increased 3.7-fold. On the other hand, E-cadherin knockdown in the statin-resistant cancer cells increased their susceptibility to statin. These results strongly suggest that E-cadherin is a statin resistance factor.

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