{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1040285300660445696.json","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"19K23730"},{"@type":"JGN","@value":"JP19K23730"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K23730/"}],"jpcoar:awardTitle":[{"@language":"ja","@value":"クロマチンを基質とした真核生物ミスマッチ修復反応の試験管内再構成系の構築"}],"field":[{"keyword":[{"language":"ja","textList":["0701:分子レベルから細胞レベルの生物学およびその関連分野"]},{"language":"en","textList":["0701:Biology at molecular to cellular levels, and related fields"]}]}],"dc:language":"ja","description":[{"type":"outline_of_research_initial","notation":[{"@language":"ja","@value":"ミスマッチ修復（MMR）はDNA合成エラーを修復することで、遺伝情報の安定維持に寄与している。我々ヒトを含む真核生物のDNAはヒストンタンパク質に巻き取られてクロマチン構造をとっている。そのため、真核生物DNA上で起きる反応の仕組みを理解するには、クロマチン構造との関係を理解することが必須である。しかし、MMRがクロマチン上で機能する仕組みはよく分かっていない。本研究では、クロマチン上でのMMRを試験管内で再構成し、反応の分子機構を明らかにする。"}]}],"researcher":[{"@id":"https://cir.nii.ac.jp/crid/1420845751139099520","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30845467"},{"@type":"NRID","@value":"1000030845467"}],"foaf:name":[{"@language":"ja","@value":"照井 利輝"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"九州大学"}],"role":"principal_investigator"}],"since":"2025-03-17","until":"2026-03-31","institution":[{"institutionIdentifier":[{"@type":"NII","@value":"0017102"}],"notation":[{"@language":"ja","@value":"九州大学"},{"@language":"en","@value":"Kyushu University"}]}],"fundingProgram":[{"jpcoar:funderName":[{"@language":"ja","@value":"科学研究費助成事業"},{"@language":"en","@value":"Grants-in-Aid for Scientific Research"}]}],"url":[{"@id":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K23730/","notation":[{"@value":"KAKEN"}]}],"createdAt":"2019-09-03","modifiedAt":"2025-11-20","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=%E3%83%9F%E3%82%B9%E3%83%9E%E3%83%83%E3%83%81%E4%BF%AE%E5%BE%A9","dc:title":"ミスマッチ修復"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%82%AF%E3%83%AD%E3%83%9E%E3%83%81%E3%83%B3%E3%83%AA%E3%83%A2%E3%83%87%E3%83%AA%E3%83%B3%E3%82%B0","dc:title":"クロマチンリモデリング"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%83%84%E3%83%A1%E3%82%AC%E3%82%A8%E3%83%AB%E5%8D%B5%E6%8A%BD%E5%87%BA%E6%B6%B2","dc:title":"ツメガエル卵抽出液"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%82%AF%E3%83%AD%E3%83%9E%E3%83%81%E3%83%B3","dc:title":"クロマチン"},{"@id":"https://cir.nii.ac.jp/all?q=%E8%A9%A6%E9%A8%93%E7%AE%A1%E5%86%85%E5%86%8D%E6%A7%8B%E6%88%90","dc:title":"試験管内再構成"}],"dataSourceIdentifier":[{"@type":"KAKEN","@value":"19K23730"}],"grant":{"grantIdentifier":[{"@type":"NII","@value":"76"}],"jpcoar:fundingStream":[{"@language":"ja","@value":"研究活動スタート支援"},{"@language":"en","@value":"Grant-in-Aid for Research Activity Start-up"}]},"allocationClassification":[{"notation":[{"@language":"ja","@value":"基金"},{"@language":"en","@value":"Multi-year Fund"}]}],"projectStatus":"granted","allocationAmount":{"totalCost":{"amount":"2860000","currency":"JPY"},"breakdownCost":[{"notation":[{"@language":"ja","@value":"直接経費"},{"@language":"en","@value":"Direct Cost"}],"amount":"2200000","currency":"JPY"},{"notation":[{"@language":"ja","@value":"間接経費"},{"@language":"en","@value":"Indirect Cost"}],"amount":"660000","currency":"JPY"}]}}