{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1040287907233292800.json","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"21K15507"},{"@type":"JGN","@value":"JP21K15507"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K15507/"}],"jpcoar:awardTitle":[{"@language":"ja","@value":"Interleukin(IL)-38を標的とした肺癌の新規免疫療法の開発"},{"@language":"en","@value":"Development of a novel immunotherapy for lung cancer targeting Interleukin(IL)-38"}],"field":[{"keyword":[{"language":"ja","textList":["小区分50010:腫瘍生物学関連"]},{"language":"en","textList":["Basic Section 50010:Tumor biology-related"]}]}],"dc:language":"ja","description":[{"type":"outline_of_research_initial","notation":[{"@language":"ja","@value":"本研究の目的は、IL-38を標的とした新たな肺癌の治療法の開発を探求することである。\nIL-38は2001年に発見された新しいサイトカインであり、IL-36シグナル系を阻害することで、抗炎症作用を示す。\n我々は過去の研究で、IL-38が腫瘍へのCD8陽性リンパ球浸潤を抑制することで、腫瘍の形成を促進することを報告した。また、肺腺癌において腫瘍細胞でのIL-38高発現が免疫チェックポイント分子であるProgramed cell death ligand 1 (PD-L1)の発現と相関することを報告した。\n本研究ではマウスモデルを用いて、IL-38を標的とした新規治療法を開発するための基礎的検討を行う。"}]}],"researcher":[{"@id":"https://cir.nii.ac.jp/crid/1420285329316301312","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20875794"},{"@type":"NRID","@value":"1000020875794"}],"foaf:name":[{"@language":"ja","@value":"木下 郁彦"},{"@language":"en","@value":"KINOSHITA Fumihiko"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"九州大学"}],"role":"principal_investigator"}],"since":"2021-04-01","until":"2024-03-31","institution":[{"institutionIdentifier":[{"@type":"NII","@value":"0017102"}],"notation":[{"@language":"ja","@value":"九州大学"},{"@language":"en","@value":"Kyushu University"}]},{"institutionIdentifier":[{"@type":"NII","@value":"0187102"}],"notation":[{"@language":"ja","@value":"独立行政法人国立病院機構(九州がんセンター臨床研究センター)"},{"@language":"en","@value":"National Hospital Organization, Kyushu Cancer Center"}]}],"fundingProgram":[{"jpcoar:funderName":[{"@language":"ja","@value":"科学研究費助成事業"},{"@language":"en","@value":"Grants-in-Aid for Scientific Research"}]}],"url":[{"@id":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K15507/","notation":[{"@value":"KAKEN"}]}],"createdAt":"2021-04-28","modifiedAt":"2025-11-20","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=%E5%8E%9F%E7%99%BA%E6%80%A7%E8%82%BA%E7%99%8C","dc:title":"原発性肺癌"},{"@id":"https://cir.nii.ac.jp/all?q=%E8%82%BA%E8%85%BA%E7%99%8C","dc:title":"肺腺癌"},{"@id":"https://cir.nii.ac.jp/all?q=%E8%85%AB%E7%98%8D%E5%BE%AE%E5%B0%8F%E7%92%B0%E5%A2%83","dc:title":"腫瘍微小環境"},{"@id":"https://cir.nii.ac.jp/all?q=Interleukin","dc:title":"Interleukin"},{"@id":"https://cir.nii.ac.jp/all?q=Interleukin-38","dc:title":"Interleukin-38"},{"@id":"https://cir.nii.ac.jp/all?q=%E8%85%AB%E7%98%8D%E9%96%A2%E9%80%A3%E5%A5%BD%E4%B8%AD%E7%90%83","dc:title":"腫瘍関連好中球"},{"@id":"https://cir.nii.ac.jp/all?q=%E8%85%AB%E7%98%8D%E9%96%A2%E9%80%A3%E3%83%9E%E3%82%AF%E3%83%AD%E3%83%95%E3%82%A1%E3%83%BC%E3%82%B8","dc:title":"腫瘍関連マクロファージ"},{"@id":"https://cir.nii.ac.jp/all?q=%E8%82%BA%E7%99%8C","dc:title":"肺癌"},{"@id":"https://cir.nii.ac.jp/all?q=%E5%85%8D%E7%96%AB%E7%99%82%E6%B3%95","dc:title":"免疫療法"},{"@id":"https://cir.nii.ac.jp/all?q=%E8%85%AB%E7%98%8D%E9%9A%8F%E4%BC%B4%E3%83%9E%E3%82%AF%E3%83%AD%E3%83%95%E3%82%A1%E3%83%BC%E3%82%B8","dc:title":"腫瘍随伴マクロファージ"},{"@id":"https://cir.nii.ac.jp/all?q=Inteleukin-38","dc:title":"Inteleukin-38"},{"@id":"https://cir.nii.ac.jp/all?q=PD-L1","dc:title":"PD-L1"}],"dataSourceIdentifier":[{"@type":"KAKEN","@value":"21K15507"}],"grant":{"grantIdentifier":[{"@type":"NII","@value":"252"}],"jpcoar:fundingStream":[{"@language":"ja","@value":"若手研究"},{"@language":"en","@value":"Grant-in-Aid for Early-Career Scientists"}]},"allocationClassification":[{"notation":[{"@language":"ja","@value":"基金"},{"@language":"en","@value":"Multi-year Fund"}]}],"projectStatus":"project_closed","allocationAmount":{"totalCost":{"amount":"4680000","currency":"JPY"},"breakdownCost":[{"notation":[{"@language":"ja","@value":"直接経費"},{"@language":"en","@value":"Direct Cost"}],"amount":"3600000","currency":"JPY"},{"notation":[{"@language":"ja","@value":"間接経費"},{"@language":"en","@value":"Indirect Cost"}],"amount":"1080000","currency":"JPY"}]}}