{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1040295802073151616.json","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23K06653"},{"@type":"JGN","@value":"JP23K06653"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K06653/"}],"jpcoar:awardTitle":[{"@language":"ja","@value":"網羅的解析による膵癌免疫抑制環境メカニズムの解明"}],"field":[{"keyword":[{"language":"ja","textList":["小区分50010:腫瘍生物学関連"]},{"language":"en","textList":["Basic Section 50010:Tumor biology-related"]}]}],"dc:language":"ja","description":[{"type":"outline_of_research_initial","notation":[{"@language":"ja","@value":"膵癌では腫瘍内に浸潤する樹状細胞(DC)が少なく、膵癌特有の抑制性の免疫微小環境が膵癌に対する免疫療法の大きな障壁となっている。近年、抗PD-1/PD-L1療法の作用機序として、癌細胞に発現するPD-L1よりも、DCが発現するPD-L1により強く働きかけ、DCを直接活性化していることが明らかになった。つまり、DCの遊走能や抗原提示能を直接活性化する治療は、免疫チェックポイント阻害剤と並ぶ抗腫瘍効果をもたらす可能性があり、膵癌特有の抑制性免疫微小環境を打破する可能性を秘めている。本研究では、ゲノムワイドスクリーニングを用いてDCの活性化を促す標的を探索し、新規免疫療法の開発を目指す。"}]}],"researcher":[{"@id":"https://cir.nii.ac.jp/crid/1420564276188792064","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70755272"},{"@type":"NRID","@value":"1000070755272"}],"foaf:name":[{"@language":"ja","@value":"三好 圭"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"九州大学"}],"role":"principal_investigator"},{"@id":"https://cir.nii.ac.jp/crid/1420282801194371712","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10783508"},{"@type":"NRID","@value":"1000010783508"},{"@type":"NRID","@value":"9000006957575"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/bonobono"}],"foaf:name":[{"@language":"ja","@value":"佐田 政史"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"九州大学"}],"role":"co_investigator_buntan"},{"@id":"https://cir.nii.ac.jp/crid/1420845751154290944","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70586859"},{"@type":"NRID","@value":"1000070586859"},{"@type":"ORCID","@value":"0000-0001-7114-7040"},{"@type":"NRID","@value":"9000006450457"}],"foaf:name":[{"@language":"ja","@value":"森山 大樹"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"九州大学"}],"role":"co_investigator_buntan"},{"@id":"https://cir.nii.ac.jp/crid/1420845751145565696","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"90761015"},{"@type":"NRID","@value":"1000090761015"}],"foaf:name":[{"@language":"ja","@value":"永吉 絹子"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"九州大学"}],"role":"co_investigator_buntan"}],"since":"2023-04-01","until":"2026-03-31","institution":[{"institutionIdentifier":[{"@type":"NII","@value":"0017102"}],"notation":[{"@language":"ja","@value":"九州大学"},{"@language":"en","@value":"Kyushu University"}]}],"fundingProgram":[{"jpcoar:funderName":[{"@language":"ja","@value":"科学研究費助成事業"},{"@language":"en","@value":"Grants-in-Aid for Scientific Research"}]}],"url":[{"@id":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K06653/","notation":[{"@value":"KAKEN"}]}],"createdAt":"2023-04-13","modifiedAt":"2025-12-26","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=%E8%86%B5%E7%99%8C","dc:title":"膵癌"},{"@id":"https://cir.nii.ac.jp/all?q=%E6%A8%B9%E7%8A%B6%E7%B4%B0%E8%83%9E(DC)","dc:title":"樹状細胞(DC)"},{"@id":"https://cir.nii.ac.jp/all?q=CRISPR-Cas9","dc:title":"CRISPR-Cas9"},{"@id":"https://cir.nii.ac.jp/all?q=Genom%20wide%20screening","dc:title":"Genom wide screening"},{"@id":"https://cir.nii.ac.jp/all?q=%E5%85%8D%E7%96%AB%E7%99%82%E6%B3%95","dc:title":"免疫療法"},{"@id":"https://cir.nii.ac.jp/all?q=%E7%99%8C%E5%BE%AE%E5%B0%8F%E7%92%B0%E5%A2%83","dc:title":"癌微小環境"},{"@id":"https://cir.nii.ac.jp/all?q=%E5%85%8D%E7%96%AB%E5%BE%AE%E5%B0%8F%E7%92%B0%E5%A2%83","dc:title":"免疫微小環境"},{"@id":"https://cir.nii.ac.jp/all?q=%E6%A8%B9%E7%8A%B6%E7%B4%B0%E8%83%9E","dc:title":"樹状細胞"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%82%B2%E3%83%8E%E3%83%A0%E3%83%AF%E3%82%A4%E3%83%89%E3%82%B9%E3%82%AF%E3%83%AA%E3%83%BC%E3%83%8B%E3%83%B3%E3%82%B0","dc:title":"ゲノムワイドスクリーニング"}],"product":[{"@id":"https://cir.nii.ac.jp/crid/1360588379370200832","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"DOI","@value":"10.1158/0008-5472.can-24-0830"},{"@type":"URI","@value":"https://aacrjournals.org/cancerres/article-pdf/doi/10.1158/0008-5472.CAN-24-0830/3498425/can-24-0830.pdf"},{"@type":"URI","@value":"https://aacrjournals.org/cancerres/article-pdf/84/24/4214/3523991/can-24-0830.pdf"}],"notation":[{"@value":"Combined Autophagy Inhibition and Dendritic Cell Recruitment Induces Antitumor Immunity and Enhances Immune Checkpoint Blockade Sensitivity in Pancreatic Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360588380592225792","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"DOI","@value":"10.1186/s13046-024-03192-8"},{"@type":"URI","@value":"https://link.springer.com/content/pdf/10.1186/s13046-024-03192-8.pdf"},{"@type":"URI","@value":"https://link.springer.com/article/10.1186/s13046-024-03192-8/fulltext.html"}],"notation":[{"@value":"Dynamic glycolytic reprogramming effects on dendritic cells in pancreatic ductal adenocarcinoma"}]}],"dataSourceIdentifier":[{"@type":"KAKEN","@value":"23K06653"}],"grant":{"grantIdentifier":[{"@type":"NII","@value":"72"}],"jpcoar:fundingStream":[{"@language":"ja","@value":"基盤研究(C)"},{"@language":"en","@value":"Grant-in-Aid for Scientific Research (C)"}]},"allocationClassification":[{"notation":[{"@language":"ja","@value":"基金"},{"@language":"en","@value":"Multi-year Fund"}]}],"projectStatus":"granted","allocationAmount":{"totalCost":{"amount":"4810000","currency":"JPY"},"breakdownCost":[{"notation":[{"@language":"ja","@value":"直接経費"},{"@language":"en","@value":"Direct Cost"}],"amount":"3700000","currency":"JPY"},{"notation":[{"@language":"ja","@value":"間接経費"},{"@language":"en","@value":"Indirect Cost"}],"amount":"1110000","currency":"JPY"}]}}