{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1040295802073217792.json","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23K06765"},{"@type":"JGN","@value":"JP23K06765"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K06765/"}],"jpcoar:awardTitle":[{"@language":"ja","@value":"メチル化ctDNAによる大腸がん根治術後再発早期診断の実装的モニタリング法の開発"}],"field":[{"keyword":[{"language":"ja","textList":["小区分50020:腫瘍診断および治療学関連"]},{"language":"en","textList":["Basic Section 50020:Tumor diagnostics and therapeutics-related"]}]}],"dc:language":"ja","description":[{"type":"outline_of_research_initial","notation":[{"@language":"ja","@value":"リキッドバイオプシーによるがん遺伝子パネル検査が保険診療下で実施可能となったが、シーケンスのコストが問題である。Stage IIまたはStage III 大腸がん術後経過をモニタリングし、同一検体を用いたctDNAゲノム変異およびctDNAメチル化の感度・特異度を比較することで、ctDNAのメチル化のサブクリニカルレベルでの有用性を示す。そして通常診療において安価に頻回の実施が可能であり、かつ、がん遺伝子パネル検査へサブクリニカルレベルで繋げていくための検査法を確立することが本研究の目的である。"}]}],"researcher":[{"@id":"https://cir.nii.ac.jp/crid/1420569149875872000","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60767375"},{"@type":"NRID","@value":"1000060767375"}],"foaf:name":[{"@language":"ja","@value":"大村 洋文"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"九州大学"}],"role":"principal_investigator"},{"@id":"https://cir.nii.ac.jp/crid/1420564276158930688","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00772493"},{"@type":"NRID","@value":"1000000772493"},{"@type":"NRID","@value":"9000368412786"},{"@type":"NRID","@value":"9000238279603"},{"@type":"NRID","@value":"9000409578214"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/atsushi_niida"}],"foaf:name":[{"@language":"ja","@value":"新井田 厚司"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"東京大学"}],"role":"co_investigator_buntan"},{"@id":"https://cir.nii.ac.jp/crid/1030285300701006848","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"40634720"},{"@type":"NRID","@value":"1000040634720"},{"@type":"NRID","@value":"9000409882869"}],"foaf:name":[{"@language":"ja","@value":"LOW SIEWKEE"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"公益財団法人がん研究会"}],"role":"co_investigator_buntan"},{"@id":"https://cir.nii.ac.jp/crid/1420564276163819392","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50322748"},{"@type":"NRID","@value":"1000050322748"},{"@type":"NRID","@value":"9000403556089"},{"@type":"NRID","@value":"9000368412805"},{"@type":"NRID","@value":"9000256300908"},{"@type":"NRID","@value":"9000242800568"},{"@type":"NRID","@value":"9000394958892"},{"@type":"NRID","@value":"9000335562404"},{"@type":"NRID","@value":"9000403555745"},{"@type":"NRID","@value":"9000240089241"},{"@type":"NRID","@value":"9000403555486"},{"@type":"NRID","@value":"9000010377447"},{"@type":"NRID","@value":"9000018214721"},{"@type":"NRID","@value":"9000006777722"},{"@type":"NRID","@value":"9000319071124"},{"@type":"NRID","@value":"9000403555666"},{"@type":"NRID","@value":"9000403555501"},{"@type":"NRID","@value":"9000394957572"},{"@type":"NRID","@value":"9000415186615"},{"@type":"NRID","@value":"9000001766211"},{"@type":"NRID","@value":"9000403555650"},{"@type":"NRID","@value":"9000403556105"},{"@type":"NRID","@value":"9000290813965"},{"@type":"NRID","@value":"9000410510163"},{"@type":"NRID","@value":"9000336053968"},{"@type":"NRID","@value":"9000259335656"},{"@type":"NRID","@value":"9000399009636"},{"@type":"NRID","@value":"9000017304820"},{"@type":"NRID","@value":"9000333085340"},{"@type":"NRID","@value":"9000398822253"},{"@type":"NRID","@value":"9000022410294"},{"@type":"NRID","@value":"9000403555824"},{"@type":"NRID","@value":"9000399540871"},{"@type":"NRID","@value":"9000398632856"},{"@type":"NRID","@value":"9000015122323"},{"@type":"NRID","@value":"9000014162896"},{"@type":"NRID","@value":"9000255327807"},{"@type":"NRID","@value":"9000408632263"},{"@type":"NRID","@value":"9000017267205"},{"@type":"NRID","@value":"9000376556407"},{"@type":"NRID","@value":"9000403555610"},{"@type":"NRID","@value":"9000415309342"},{"@type":"NRID","@value":"9000368920975"},{"@type":"NRID","@value":"9000403555809"},{"@type":"NRID","@value":"9000403555538"},{"@type":"NRID","@value":"9000403556029"},{"@type":"NRID","@value":"9000409578218"},{"@type":"NRID","@value":"9000001904772"},{"@type":"NRID","@value":"9000403556055"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0067479"}],"foaf:name":[{"@language":"ja","@value":"三森 功士"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"九州大学"}],"role":"co_investigator_buntan"},{"@id":"https://cir.nii.ac.jp/crid/1420564276188299392","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70362499"},{"@type":"NRID","@value":"1000070362499"},{"@type":"NRID","@value":"9000001453391"},{"@type":"NRID","@value":"9000398454580"},{"@type":"NRID","@value":"9000006960038"},{"@type":"NRID","@value":"9000326656717"},{"@type":"NRID","@value":"9000398611207"},{"@type":"NRID","@value":"9000403835334"},{"@type":"NRID","@value":"9000397845217"},{"@type":"NRID","@value":"9000003126558"},{"@type":"NRID","@value":"9000345329530"},{"@type":"NRID","@value":"9000398609721"},{"@type":"NRID","@value":"9000337095949"},{"@type":"NRID","@value":"9000399379161"},{"@type":"NRID","@value":"9000257706858"},{"@type":"NRID","@value":"9000255893632"},{"@type":"NRID","@value":"9000380430901"},{"@type":"NRID","@value":"9000258280169"},{"@type":"NRID","@value":"9000257712718"},{"@type":"NRID","@value":"9000356891655"},{"@type":"NRID","@value":"9000024111312"},{"@type":"NRID","@value":"9000391590984"},{"@type":"NRID","@value":"9000258275729"},{"@type":"NRID","@value":"9000376551987"},{"@type":"NRID","@value":"9000240072481"},{"@type":"NRID","@value":"9000399579163"},{"@type":"NRID","@value":"9000398610407"},{"@type":"NRID","@value":"9000256302495"},{"@type":"NRID","@value":"9000356570128"},{"@type":"NRID","@value":"9000021528078"},{"@type":"NRID","@value":"9000402439303"},{"@type":"NRID","@value":"9000257186644"},{"@type":"NRID","@value":"9000391591010"},{"@type":"NRID","@value":"9000283744342"},{"@type":"NRID","@value":"9000332702562"},{"@type":"NRID","@value":"9000345338982"},{"@type":"NRID","@value":"9000255891108"},{"@type":"NRID","@value":"9000398609807"},{"@type":"NRID","@value":"9000022345224"},{"@type":"NRID","@value":"9000338426464"},{"@type":"NRID","@value":"9000255686635"},{"@type":"NRID","@value":"9000396110555"},{"@type":"NRID","@value":"9000340948656"},{"@type":"NRID","@value":"9000391415143"},{"@type":"NRID","@value":"9000240072443"}],"foaf:name":[{"@language":"ja","@value":"長山 聡"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"京都大学"}],"role":"co_investigator_buntan"}],"since":"2023-04-01","until":"2026-03-31","institution":[{"institutionIdentifier":[{"@type":"NII","@value":"0017102"}],"notation":[{"@language":"ja","@value":"九州大学"},{"@language":"en","@value":"Kyushu University"}]}],"fundingProgram":[{"jpcoar:funderName":[{"@language":"ja","@value":"科学研究費助成事業"},{"@language":"en","@value":"Grants-in-Aid for Scientific Research"}]}],"url":[{"@id":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K06765/","notation":[{"@value":"KAKEN"}]}],"createdAt":"2023-04-13","modifiedAt":"2025-12-26","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=ctDNA","dc:title":"ctDNA"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%83%A1%E3%83%81%E3%83%AB%E5%8C%96%E3%83%90%E3%82%A4%E3%82%AA%E3%83%9E%E3%83%BC%E3%82%AB%E3%83%BC","dc:title":"メチル化バイオマーカー"},{"@id":"https://cir.nii.ac.jp/all?q=%E5%A4%A7%E8%85%B8%E3%81%8C%E3%82%93%E6%97%A9%E6%9C%9F%E7%99%BA%E8%A6%8B","dc:title":"大腸がん早期発見"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%83%87%E3%82%B8%E3%82%BF%E3%83%ABPCR%EF%BC%88dPCR%EF%BC%89","dc:title":"デジタルPCR（dPCR）"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%83%AA%E3%82%AD%E3%83%83%E3%83%89%E3%83%90%E3%82%A4%E3%82%AA%E3%83%97%E3%82%B7%E3%83%BC","dc:title":"リキッドバイオプシー"},{"@id":"https://cir.nii.ac.jp/all?q=%E5%AE%9F%E8%A3%85%E6%80%A7","dc:title":"実装性"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%83%A1%E3%83%81%E3%83%AB%E5%8C%96ctDNA","dc:title":"メチル化ctDNA"},{"@id":"https://cir.nii.ac.jp/all?q=MRD","dc:title":"MRD"},{"@id":"https://cir.nii.ac.jp/all?q=dPCR","dc:title":"dPCR"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%82%B7%E3%83%9F%E3%83%A5%E3%83%AC%E3%83%BC%E3%82%B7%E3%83%A7%E3%83%B3","dc:title":"シミュレーション"},{"@id":"https://cir.nii.ac.jp/all?q=DNA%E3%83%A1%E3%83%81%E3%83%AB%E5%8C%96","dc:title":"DNAメチル化"},{"@id":"https://cir.nii.ac.jp/all?q=%E5%A4%A7%E8%85%B8%E3%81%8C%E3%82%93","dc:title":"大腸がん"},{"@id":"https://cir.nii.ac.jp/all?q=%E6%97%A9%E6%9C%9F%E8%A8%BA%E6%96%AD","dc:title":"早期診断"}],"product":[{"@id":"https://cir.nii.ac.jp/crid/1360580229818807296","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"DOI","@value":"10.21873/cgp.20373"},{"@type":"URI","@value":"https://syndication.highwire.org/content/doi/10.21873/cgp.20373"},{"@type":"PMID","@value":"36870689"}],"notation":[{"@value":"Dynamic Changes in Peripheral Systemic Immunity Markers During Chemotherapy in HER2-negative Advanced Breast Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360021389820349696","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"DOI","@value":"10.1007/s12282-024-01556-8"},{"@type":"URI","@value":"https://link.springer.com/content/pdf/10.1007/s12282-024-01556-8.pdf"},{"@type":"URI","@value":"https://link.springer.com/article/10.1007/s12282-024-01556-8/fulltext.html"}],"notation":[{"@value":"Liquid biopsy for breast cancer and other solid tumors: a review of recent advances"}]},{"@id":"https://cir.nii.ac.jp/crid/1360021389826787712","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"DOI","@value":"10.1159/000530927"},{"@type":"URI","@value":"https://karger.com/cro/article-pdf/16/1/490/4012078/000530927.pdf"}],"notation":[{"@value":"Trousseau’s Syndrome with Advanced Neuroendocrine Carcinoma of Colon: A Case Report"}]},{"@id":"https://cir.nii.ac.jp/crid/1360302865559906944","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"DOI","@value":"10.3389/fonc.2024.1340419"},{"@type":"URI","@value":"https://www.frontiersin.org/articles/10.3389/fonc.2024.1340419/full"}],"notation":[{"@value":"Case report: A rare case of triple negative breast cancer with development of acute pancreatitis due to dexamethasone during adjuvant chemotherapy"}]}],"dataSourceIdentifier":[{"@type":"KAKEN","@value":"23K06765"}],"grant":{"grantIdentifier":[{"@type":"NII","@value":"72"}],"jpcoar:fundingStream":[{"@language":"ja","@value":"基盤研究(C)"},{"@language":"en","@value":"Grant-in-Aid for Scientific Research (C)"}]},"allocationClassification":[{"notation":[{"@language":"ja","@value":"基金"},{"@language":"en","@value":"Multi-year Fund"}]}],"projectStatus":"granted","allocationAmount":{"totalCost":{"amount":"4680000","currency":"JPY"},"breakdownCost":[{"notation":[{"@language":"ja","@value":"直接経費"},{"@language":"en","@value":"Direct Cost"}],"amount":"3600000","currency":"JPY"},{"notation":[{"@language":"ja","@value":"間接経費"},{"@language":"en","@value":"Indirect Cost"}],"amount":"1080000","currency":"JPY"}]}}