{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1040295802076966912.json","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23K14715"},{"@type":"JGN","@value":"JP23K14715"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K14715/"}],"jpcoar:awardTitle":[{"@language":"ja","@value":"神経性やせ症の病態形成に尿毒症毒素が及ぼす影響の解明"}],"field":[{"keyword":[{"language":"ja","textList":["小区分52010:内科学一般関連"]},{"language":"en","textList":["Basic Section 52010:General internal medicine-related"]}]}],"dc:language":"ja","description":[{"type":"outline_of_research_initial","notation":[{"@language":"ja","@value":"神経性やせ症（Anorexia nervosa：AN）は極度の低体重を呈する難治性疾患である。申請者らはこれまでAN患者の腸内細菌叢の異常、それが体重増加不良や不安様行動の発現に関与し、AN患者では腸内細菌が生成に関与する尿毒症毒素（Uremic Toxin：以下 UTx）の濃度が高いことを明らかにした。一方、高値であったUTxは非アルコール性脂肪性肝疾患の原因物質として注目され、AN患者の脂肪肝との関連も推測される。本研究ではANモデルマウスを用い、AN患者の腸内細菌叢がUTx生成に及ぼす影響、UTxがAN患者の病態に及ぼす影響を科学的に検証し、AN治療に有効な栄養療法、薬物療法を開発する。"}]}],"researcher":[{"@id":"https://cir.nii.ac.jp/crid/1420001326228547968","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10535983"},{"@type":"NRID","@value":"1000010535983"},{"@type":"NRID","@value":"9000403560705"},{"@type":"NRID","@value":"9000342796707"},{"@type":"NRID","@value":"9000283501960"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/psychosomatic"}],"foaf:name":[{"@language":"ja","@value":"波夛 伴和"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"九州大学"}],"role":"principal_investigator"}],"since":"2023-04-01","until":"2027-03-31","institution":[{"institutionIdentifier":[{"@type":"NII","@value":"0017102"}],"notation":[{"@language":"ja","@value":"九州大学"},{"@language":"en","@value":"Kyushu University"}]}],"fundingProgram":[{"jpcoar:funderName":[{"@language":"ja","@value":"科学研究費助成事業"},{"@language":"en","@value":"Grants-in-Aid for Scientific Research"}]}],"url":[{"@id":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K14715/","notation":[{"@value":"KAKEN"}]}],"createdAt":"2023-04-13","modifiedAt":"2025-12-26","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=%E7%A5%9E%E7%B5%8C%E6%80%A7%E3%82%84%E3%81%9B%E7%97%87","dc:title":"神経性やせ症"},{"@id":"https://cir.nii.ac.jp/all?q=%E8%85%B8%E5%86%85%E7%B4%B0%E8%8F%8C","dc:title":"腸内細菌"},{"@id":"https://cir.nii.ac.jp/all?q=%E5%B0%BF%E6%AF%92%E7%97%87%E6%AF%92%E7%B4%A0","dc:title":"尿毒症毒素"},{"@id":"https://cir.nii.ac.jp/all?q=%E8%84%82%E8%82%AA%E8%82%9D","dc:title":"脂肪肝"},{"@id":"https://cir.nii.ac.jp/all?q=%E6%A0%84%E9%A4%8A%E7%99%82%E6%B3%95","dc:title":"栄養療法"}],"product":[{"@id":"https://cir.nii.ac.jp/crid/1390583502303571712","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"DOI","@value":"10.15064/jjpm.64.6_499"}],"notation":[{"@language":"ja","@value":"司会のことば"}]},{"@id":"https://cir.nii.ac.jp/crid/1390583502303572736","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"DOI","@value":"10.15064/jjpm.64.6_505"}],"notation":[{"@language":"en","@value":"The Importance of Psychosocial Care and the Mind-Body Correlation in Diabetes"},{"@language":"ja","@value":"糖尿病における心身相関と心理社会的ケアの役割"}]},{"@id":"https://cir.nii.ac.jp/crid/1010306730207113218","@type":"Article","resourceType":"学術雑誌論文(journal article)","notation":[{"@language":"ja","@value":"Energy requirements for weight gain in patients with anorexia nervosa: a study from a Japanese medical prison"}]}],"dataSourceIdentifier":[{"@type":"KAKEN","@value":"23K14715"}],"grant":{"grantIdentifier":[{"@type":"NII","@value":"252"}],"jpcoar:fundingStream":[{"@language":"ja","@value":"若手研究"},{"@language":"en","@value":"Grant-in-Aid for Early-Career Scientists"}]},"allocationClassification":[{"notation":[{"@language":"ja","@value":"基金"},{"@language":"en","@value":"Multi-year Fund"}]}],"projectStatus":"granted","allocationAmount":{"totalCost":{"amount":"4680000","currency":"JPY"},"breakdownCost":[{"notation":[{"@language":"ja","@value":"直接経費"},{"@language":"en","@value":"Direct Cost"}],"amount":"3600000","currency":"JPY"},{"notation":[{"@language":"ja","@value":"間接経費"},{"@language":"en","@value":"Indirect Cost"}],"amount":"1080000","currency":"JPY"}]}}