{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1040295802078324096.json","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23H00391"},{"@type":"JGN","@value":"JP23H00391"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23H00391/"}],"jpcoar:awardTitle":[{"@language":"ja","@value":"脳老化と神経疾患に共通した脳機能低下に懸かる細胞間相互作用機序の統合的理解"},{"@language":"en","@value":"Integrated understanding of cell-cell interaction mechanisms underlying brain dysfunction common to brain aging and neurological disorders"}],"field":[{"keyword":[{"language":"ja","textList":["中区分46:神経科学およびその関連分野"]},{"language":"en","textList":["Medium-sized Section 46:Neuroscience and related fields"]}]}],"dc:language":"ja","description":[{"type":"outline_of_research_initial","notation":[{"@language":"ja","@value":"加齢に伴い脳老化・機能低下が進行する。この原因として神経細胞の機能や新生神経細胞能の低下が考えられるが、その機序は不明である。一方で、神経疾患脳で実は、細胞老化や炎症の亢進が観察されている。そこで本研究では、老齢及び神経疾患脳内でどの細胞種がどのようなエピゲノム状態を取ることで老化状態に陥り、脳内炎症が誘発され脳機能低下に至るのか、その共通原理を明らかにする。さらに、逆転写酵素阻害剤の投与でレトロトランスポゾンのcDNA合成を阻害し、細胞間相互作用を抑制することで、脳機能低下が改善できるかどうかも検討する。本研究の遂行により、老化と神経疾患に共通した、神経機能維持・改善方法の提示が期待できる。"}]}],"researcher":[{"@id":"https://cir.nii.ac.jp/crid/1420564276178195200","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80302892"},{"@type":"NRID","@value":"1000080302892"},{"@type":"ORCID","@value":"0000-0001-5901-9628"},{"@type":"NRID","@value":"9000018475251"},{"@type":"NRID","@value":"9000258714131"},{"@type":"NRID","@value":"9000253552268"},{"@type":"NRID","@value":"9000391994796"},{"@type":"NRID","@value":"9000242703641"},{"@type":"NRID","@value":"9000018927450"},{"@type":"NRID","@value":"9000399814441"},{"@type":"NRID","@value":"9000317166602"},{"@type":"NRID","@value":"9000317166619"},{"@type":"NRID","@value":"9000392065365"},{"@type":"NRID","@value":"9000410151270"},{"@type":"NRID","@value":"9000399595369"},{"@type":"NRID","@value":"9000347069403"},{"@type":"NRID","@value":"9000017610726"},{"@type":"NRID","@value":"9000346921080"},{"@type":"NRID","@value":"9000019075581"},{"@type":"NRID","@value":"9000023352642"},{"@type":"NRID","@value":"9000316223291"},{"@type":"NRID","@value":"9000317166626"},{"@type":"NRID","@value":"9000317166606"},{"@type":"NRID","@value":"9000018215107"},{"@type":"NRID","@value":"9000002122077"},{"@type":"NRID","@value":"9000275834438"},{"@type":"NRID","@value":"9000018890635"},{"@type":"NRID","@value":"9000347224491"},{"@type":"NRID","@value":"9000253552269"},{"@type":"NRID","@value":"9000317166584"},{"@type":"NRID","@value":"9000283731557"},{"@type":"NRID","@value":"9000283729708"},{"@type":"NRID","@value":"9000253180573"},{"@type":"NRID","@value":"9000253552252"},{"@type":"NRID","@value":"9000375852316"},{"@type":"NRID","@value":"9000408426907"},{"@type":"NRID","@value":"9000391992802"},{"@type":"NRID","@value":"9000317166595"},{"@type":"NRID","@value":"9000253471015"},{"@type":"NRID","@value":"9000018385028"},{"@type":"NRID","@value":"9000317166572"},{"@type":"NRID","@value":"9000356479227"},{"@type":"NRID","@value":"9000356510491"},{"@type":"NRID","@value":"9000008824175"},{"@type":"NRID","@value":"9000255953276"},{"@type":"NRID","@value":"9000336374890"},{"@type":"NRID","@value":"9000341540941"},{"@type":"NRID","@value":"9000414742154"},{"@type":"NRID","@value":"9000255679758"},{"@type":"NRID","@value":"9000242349096"},{"@type":"NRID","@value":"9000317166633"},{"@type":"NRID","@value":"9000317166589"},{"@type":"NRID","@value":"9000253552253"},{"@type":"NRID","@value":"9000392068633"},{"@type":"NRID","@value":"9000018542980"},{"@type":"NRID","@value":"9000331448701"},{"@type":"NRID","@value":"9000283893764"},{"@type":"NRID","@value":"9000010183118"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/kinichinakashima"}],"foaf:name":[{"@language":"ja","@value":"中島 欽一"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"九州大学"}],"role":"principal_investigator"},{"@id":"https://cir.nii.ac.jp/crid/1420564276185371136","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"40616322"},{"@type":"NRID","@value":"1000040616322"},{"@type":"NRID","@value":"9000411520561"},{"@type":"NRID","@value":"9000412129000"},{"@type":"NRID","@value":"9000006711773"},{"@type":"NRID","@value":"9000021944272"},{"@type":"NRID","@value":"9000413906981"},{"@type":"NRID","@value":"9000410295007"},{"@type":"NRID","@value":"9000399596125"},{"@type":"NRID","@value":"9000403323281"},{"@type":"NRID","@value":"9000412561334"},{"@type":"NRID","@value":"9000006297056"},{"@type":"NRID","@value":"9000399175361"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0155308"}],"foaf:name":[{"@language":"ja","@value":"城村 由和"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"金沢大学"}],"role":"co_investigator_buntan"}],"since":"2023-04-01","until":"2027-03-31","institution":[{"institutionIdentifier":[{"@type":"NII","@value":"0017102"}],"notation":[{"@language":"ja","@value":"九州大学"},{"@language":"en","@value":"Kyushu University"}]}],"fundingProgram":[{"jpcoar:funderName":[{"@language":"ja","@value":"科学研究費助成事業"},{"@language":"en","@value":"Grants-in-Aid for Scientific Research"}]},{"jpcoar:funderName":[{"@language":"ja","@value":"科学研究費助成事業"}]}],"url":[{"@id":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23H00391/","notation":[{"@value":"KAKEN"}]}],"createdAt":"2023-04-13","modifiedAt":"2026-04-10","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=%E7%B2%BE%E7%A5%9E%E3%83%BB%E7%A5%9E%E7%B5%8C%E7%96%BE%E6%82%A3","dc:title":"精神・神経疾患"},{"@id":"https://cir.nii.ac.jp/all?q=%E8%80%81%E5%8C%96","dc:title":"老化"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%83%AC%E3%83%83%E3%83%88%E7%97%87%E5%80%99%E7%BE%A4","dc:title":"レット症候群"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%83%AC%E3%83%88%E3%83%AD%E3%83%88%E3%83%A9%E3%83%B3%E3%82%B9%E3%83%9D%E3%82%BE%E3%83%B3","dc:title":"レトロトランスポゾン"},{"@id":"https://cir.nii.ac.jp/all?q=%E9%80%86%E8%BB%A2%E5%86%99%E9%85%B5%E7%B4%A0%E9%98%BB%E5%AE%B3%E5%89%A4","dc:title":"逆転写酵素阻害剤"},{"@id":"https://cir.nii.ac.jp/all?q=%E8%84%B3%E8%80%81%E5%8C%96","dc:title":"脳老化"},{"@id":"https://cir.nii.ac.jp/all?q=%E7%A5%9E%E7%B5%8C%E7%96%BE%E6%82%A3","dc:title":"神経疾患"},{"@id":"https://cir.nii.ac.jp/all?q=%E7%B4%B0%E8%83%9E%E9%96%93%E7%9B%B8%E4%BA%92%E4%BD%9C%E7%94%A8","dc:title":"細胞間相互作用"}],"product":[{"@id":"https://cir.nii.ac.jp/crid/1050585128045266688","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"HDL","@value":"http://hdl.handle.net/10458/0002001048"},{"@type":"URI","@value":"https://miyazaki-u.repo.nii.ac.jp/records/2001048"},{"@type":"DOI","@value":"10.1038/s44319-024-00205-7"},{"@type":"URI","@value":"https://www.embopress.org/doi/epdf/10.1038/s44319-024-00205-7"},{"@type":"URI","@value":"https://www.embopress.org/doi/full/10.1038/s44319-024-00205-7"}],"notation":[{"@language":"en","@value":"The Derlin-1-Stat5b axis maintains homeostasis of adult hippocampal neurogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360869855122070016","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"DOI","@value":"10.1016/j.stemcr.2024.06.013"},{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S2213671124001930?httpAccept=text/xml"},{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S2213671124001930?httpAccept=text/plain"}],"notation":[{"@value":"Human microglial cells as a therapeutic target in a neurodevelopmental disease model"}]},{"@id":"https://cir.nii.ac.jp/crid/1360869854363171712","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"DOI","@value":"10.3390/epigenomes8020022"},{"@type":"URI","@value":"https://www.mdpi.com/2075-4655/8/2/22/pdf"}],"notation":[{"@value":"Epigenetic Regulation of Neural Stem Cells in Developmental and Adult Stages"}]},{"@id":"https://cir.nii.ac.jp/crid/1050870860996435584","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"HDL","@value":"http://hdl.handle.net/10061/0002001417"},{"@type":"URI","@value":"https://naist.repo.nii.ac.jp/records/2001417"}],"notation":[{"@language":"en","@value":"Histone methyltransferase Setd8 preserves chromatin accessibility to safeguard retinal progenitor cell identity during development"}]}],"dataSourceIdentifier":[{"@type":"KAKEN","@value":"23H00391"},{"@type":"IRDB","@value":"oai:irdb.nii.ac.jp:01146:0007337365_JGN_UoaYh8x3jztOeuQrrnglUaGAUsn"}],"grant":{"grantIdentifier":[{"@type":"NII","@value":"68"}],"jpcoar:fundingStream":[{"@language":"ja","@value":"基盤研究(A)"},{"@language":"en","@value":"Grant-in-Aid for Scientific Research (A)"}]},"allocationClassification":[{"notation":[{"@language":"ja","@value":"補助金"},{"@language":"en","@value":"Single-year Grants"}]}],"projectStatus":"granted","allocationAmount":{"totalCost":{"amount":"46930000","currency":"JPY"},"breakdownCost":[{"notation":[{"@language":"ja","@value":"直接経費"},{"@language":"en","@value":"Direct Cost"}],"amount":"36100000","currency":"JPY"},{"notation":[{"@language":"ja","@value":"間接経費"},{"@language":"en","@value":"Indirect Cost"}],"amount":"10830000","currency":"JPY"}]}}