{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1040295879330512896.json","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"22KJ2457"},{"@type":"JGN","@value":"JP22KJ2457"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22KJ2457/"}],"jpcoar:awardTitle":[{"@language":"ja","@value":"液性免疫応答における小胞体恒常性の生理的役割"}],"field":[{"keyword":[{"language":"ja","textList":["小区分49070:免疫学関連"]},{"language":"en","textList":["Basic Section 49070:Immunology-related"]}]}],"dc:language":"ja","description":[{"type":"outline_of_research_initial","notation":[{"@language":"ja","@value":"液性免疫応答は生体防御のメカニズムとして重要である。液性免疫の主役を担うのはB細胞であり、B細胞の小胞体恒常性維持がB細胞分化と抗体産生に密接に関与する。小胞体はタンパク質の品質管理と細胞質内Ca2+濃度の調節が主な機能として知られており、これら2つの機能を制御することが小胞体恒常性に重要である。そこで細胞内及び小胞体カルシウム濃度の調節と複数回膜貫通型タンパク質の恒常性に重要である分子EMC1に着目し、B細胞における機能解析を行う。これにより、液性免疫における小胞体恒常生の生理学的役割の解明を目指す。"}]}],"researcher":[{"@id":"https://cir.nii.ac.jp/crid/1030015487558123264","@type":"Researcher","foaf:name":[{"@language":"ja","@value":"河田 和彦"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"九州大学"}],"role":"principal_investigator"}],"since":"2023-03-08","until":"2025-03-31","institution":[{"institutionIdentifier":[{"@type":"NII","@value":"0017102"}],"notation":[{"@language":"ja","@value":"九州大学"},{"@language":"en","@value":"Kyushu University"}]}],"fundingProgram":[{"jpcoar:funderName":[{"@language":"ja","@value":"科学研究費助成事業"},{"@language":"en","@value":"Grants-in-Aid for Scientific Research"}]}],"url":[{"@id":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22KJ2457/","notation":[{"@value":"KAKEN"}]}],"createdAt":"2022-04-28","modifiedAt":"2025-12-26","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=B%E7%B4%B0%E8%83%9E","dc:title":"B細胞"},{"@id":"https://cir.nii.ac.jp/all?q=%E6%B6%B2%E6%80%A7%E5%85%8D%E7%96%AB%E5%BF%9C%E7%AD%94","dc:title":"液性免疫応答"},{"@id":"https://cir.nii.ac.jp/all?q=%E5%B0%8F%E8%83%9E%E4%BD%93","dc:title":"小胞体"},{"@id":"https://cir.nii.ac.jp/all?q=%E8%86%9C%E3%82%BF%E3%83%B3%E3%83%91%E3%82%AF%E8%B3%AA","dc:title":"膜タンパク質"},{"@id":"https://cir.nii.ac.jp/all?q=Ca2+","dc:title":"Ca2+"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%82%B1%E3%83%A2%E3%82%AB%E3%82%A4%E3%83%B3%E5%8F%97%E5%AE%B9%E4%BD%93","dc:title":"ケモカイン受容体"},{"@id":"https://cir.nii.ac.jp/all?q=IL-10","dc:title":"IL-10"},{"@id":"https://cir.nii.ac.jp/all?q=B%E7%B4%B0%E8%83%9E%E5%88%86%E5%8C%96","dc:title":"B細胞分化"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%82%AF%E3%83%A9%E3%82%B9%E3%82%B9%E3%82%A4%E3%83%83%E3%83%81","dc:title":"クラススイッチ"},{"@id":"https://cir.nii.ac.jp/all?q=Plasma%E7%B4%B0%E8%83%9E","dc:title":"Plasma細胞"}],"product":[{"@id":"https://cir.nii.ac.jp/crid/1360305186323165568","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"DOI","@value":"10.3389/fimmu.2024.1388947"},{"@type":"URI","@value":"https://www.frontiersin.org/articles/10.3389/fimmu.2024.1388947/full"}],"notation":[{"@value":"Bruton’s tyrosine kinase inhibition limits endotoxic shock by suppressing IL-6 production by marginal zone B cells in mice"}]}],"dataSourceIdentifier":[{"@type":"KAKEN","@value":"22KJ2457"}],"grant":{"grantIdentifier":[{"@type":"NII","@value":"42"}],"jpcoar:fundingStream":[{"@language":"ja","@value":"特別研究員奨励費"},{"@language":"en","@value":"Grant-in-Aid for JSPS Fellows"}]},"allocationClassification":[{"notation":[{"@language":"ja","@value":"基金"},{"@language":"en","@value":"Multi-year Fund"}]},{"notation":[{"@language":"ja","@value":"補助金"},{"@language":"en","@value":"Single-year Grants"}]}],"projectStatus":"project_closed","allocationAmount":{"totalCost":{"amount":"2500000","currency":"JPY"},"breakdownCost":[{"notation":[{"@language":"ja","@value":"直接経費"},{"@language":"en","@value":"Direct Cost"}],"amount":"2500000","currency":"JPY"},{"notation":[{"@language":"ja","@value":"間接経費"},{"@language":"en","@value":"Indirect Cost"}],"amount":"0","currency":"JPY"}]}}