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science-related"]}]}],"dc:language":"ja","description":[{"type":"outline_of_research_initial","notation":[{"@language":"ja","@value":"口腔がんのリンパ節転移は不顕性に進行し、転移後に発見されるケースが多い。患者のQOL向上のために、低侵襲的な口腔がんのリンパ節転移に対する新規治療法が必要である。センチネルリンパ節は、がん遠隔転移の防波堤である。がん転移センチネルリンパ節では、線維芽細胞様細網細胞による物質輸送系の線維化が起こり、T細胞による抗腫瘍免疫機能が低下すると考えられている。本研究では、口腔がん細胞が線維芽細胞様細網細胞を介して抗腫瘍免疫機能を抑制するメカニズムおよびセンチネルリンパ節への転移機序を解明し、センチネルリンパ節転移に対する非外科的治療法の学術的基盤の確立を目指す。"}]}],"researcher":[{"@id":"https://cir.nii.ac.jp/crid/1420282801201496576","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80304814"},{"@type":"NRID","@value":"1000080304814"},{"@type":"ORCID","@value":"0000-0001-7055-3370"},{"@type":"NRID","@value":"9000004728015"},{"@type":"NRID","@value":"9000414725108"},{"@type":"NRID","@value":"9000000764288"},{"@type":"NRID","@value":"9000238261050"},{"@type":"NRID","@value":"9000399173929"},{"@type":"NRID","@value":"9000004732061"},{"@type":"NRID","@value":"9000397964042"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/Takaja11"}],"foaf:name":[{"@language":"ja","@value":"山座 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