{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1040566775678963072.json","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"20K10074"},{"@type":"JGN","@value":"JP20K10074"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K10074/"}],"jpcoar:awardTitle":[{"@language":"ja","@value":"骨質劣化によるインプラント周囲骨代謝破綻機序の解明と既存薬の骨質制御法への応用"},{"@language":"en","@value":"Elucidation of the mechanism of peri-implant bone metabolism disruption due to osteoporosis and application of existing drugs to bone quality improvement methods"}],"field":[{"keyword":[{"language":"ja","textList":["小区分57050:補綴系歯学関連"]},{"language":"en","textList":["Basic Section 57050:Prosthodontics-related"]}]}],"dc:language":"ja","description":[{"type":"outline_of_research_initial","notation":[{"@language":"ja","@value":"全身の骨量や骨強度（骨密度・骨質）の低下は、超高齢化社会において健康寿命の延伸の妨げになるロコモティブシンドロームを増加させる要因の一つである。顎骨の骨代謝は全身の骨代謝の影響を受けることが報告されており、顎骨内に埋入され骨との強固な固定（オッセオインテグレーション）が機能維持において必須であるインプラントは、全身疾患による骨質変動に影響されると考えられるが、その経時的な骨動態の詳細は分かっていないところが多い。そこで本研究では、インプラント周囲の骨動態を骨細胞ネットワークおよび骨質に着目して検討し、骨質劣化時のインプラント周囲骨リモデリングを適正化する新規ドラッグリポジショニングを目指す。"}]}],"researcher":[{"@id":"https://cir.nii.ac.jp/crid/1420845751140792832","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50452769"},{"@type":"NRID","@value":"1000050452769"},{"@type":"NRID","@value":"9000005885059"},{"@type":"NRID","@value":"9000021313931"},{"@type":"NRID","@value":"9000006330242"},{"@type":"NRID","@value":"9000364993986"},{"@type":"NRID","@value":"9000391955838"},{"@type":"NRID","@value":"9000014180548"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/ymoriyama"}],"foaf:name":[{"@language":"ja","@value":"森山 泰子"},{"@language":"en","@value":"Moriyama Yasuko"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"九州大学"}],"role":"principal_investigator"},{"@id":"https://cir.nii.ac.jp/crid/1420564276174864128","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50304697"},{"@type":"NRID","@value":"1000050304697"},{"@type":"ORCID","@value":"0000-0003-0039-716X"},{"@type":"NRID","@value":"9000001168220"},{"@type":"NRID","@value":"9000021313938"},{"@type":"NRID","@value":"9000397661635"},{"@type":"NRID","@value":"9000408484412"},{"@type":"NRID","@value":"9000002155950"},{"@type":"NRID","@value":"9000000764499"},{"@type":"NRID","@value":"9000411277820"},{"@type":"NRID","@value":"9000020510474"},{"@type":"NRID","@value":"9000410273184"},{"@type":"NRID","@value":"9000316215235"},{"@type":"NRID","@value":"9000259840380"},{"@type":"NRID","@value":"9000005487564"},{"@type":"NRID","@value":"9000305612607"},{"@type":"NRID","@value":"9000412282765"},{"@type":"NRID","@value":"9000409465818"},{"@type":"NRID","@value":"9000242117433"},{"@type":"NRID","@value":"9000386335245"},{"@type":"NRID","@value":"9000412282336"},{"@type":"NRID","@value":"9000403421282"},{"@type":"NRID","@value":"9000347662747"},{"@type":"NRID","@value":"9000413896988"},{"@type":"NRID","@value":"9000283625941"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0162767"}],"foaf:name":[{"@language":"ja","@value":"鮎川 保則"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"九州大学"}],"role":"co_investigator_buntan"},{"@id":"https://cir.nii.ac.jp/crid/1420001326212128768","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60778869"},{"@type":"NRID","@value":"1000060778869"}],"foaf:name":[{"@language":"ja","@value":"竹村 陽子"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"九州大学"}],"role":"co_investigator_buntan"},{"@id":"https://cir.nii.ac.jp/crid/1420282801197974144","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50195872"},{"@type":"NRID","@value":"1000050195872"},{"@type":"ORCID","@value":"0000-0001-7459-0101"},{"@type":"NDL_AUTHOR_ID","@value":"01010529"},{"@type":"NRID","@value":"9000020383907"},{"@type":"NRID","@value":"9000020315533"},{"@type":"NRID","@value":"9000021313993"},{"@type":"NRID","@value":"9000254876592"},{"@type":"NRID","@value":"9000002155952"},{"@type":"NRID","@value":"9000258228378"},{"@type":"NRID","@value":"9000020510233"},{"@type":"NRID","@value":"9000002677292"},{"@type":"NRID","@value":"9000020337967"},{"@type":"NRID","@value":"9000020469792"},{"@type":"NRID","@value":"9000412371211"},{"@type":"NRID","@value":"9000021492795"},{"@type":"NRID","@value":"9000351205952"},{"@type":"NRID","@value":"9000389941867"},{"@type":"NRID","@value":"9000283625973"},{"@type":"NRID","@value":"9000258228365"},{"@type":"NRID","@value":"9000020545044"},{"@type":"NRID","@value":"9000020312605"},{"@type":"NRID","@value":"9000021430512"},{"@type":"NRID","@value":"9000347129718"},{"@type":"NRID","@value":"9000001726603"},{"@type":"NRID","@value":"9000363400342"},{"@type":"NRID","@value":"9000259840382"},{"@type":"NRID","@value":"9000020360523"},{"@type":"NRID","@value":"9000020383003"},{"@type":"NRID","@value":"9000283625910"},{"@type":"NRID","@value":"9000258228659"},{"@type":"NRID","@value":"9000021177438"},{"@type":"NRID","@value":"9000273025149"},{"@type":"NRID","@value":"9000020509699"},{"@type":"NRID","@value":"9000020359837"},{"@type":"NRID","@value":"9000020501841"},{"@type":"NRID","@value":"9000020474078"},{"@type":"NRID","@value":"9000283625841"},{"@type":"NRID","@value":"9000254877038"},{"@type":"NRID","@value":"9000021226144"},{"@type":"NRID","@value":"9000020360437"},{"@type":"NRID","@value":"9000019977891"},{"@type":"NRID","@value":"9000347662752"},{"@type":"NRID","@value":"9000283625942"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0043322"}],"foaf:name":[{"@language":"ja","@value":"古谷野 潔"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"九州大学"}],"role":"co_investigator_buntan"}],"since":"2020-04-01","until":"2025-03-31","institution":[{"institutionIdentifier":[{"@type":"NII","@value":"0017102"}],"notation":[{"@language":"ja","@value":"九州大学"},{"@language":"en","@value":"Kyushu University"}]}],"fundingProgram":[{"jpcoar:funderName":[{"@language":"ja","@value":"科学研究費助成事業"},{"@language":"en","@value":"Grants-in-Aid for Scientific Research"}]}],"url":[{"@id":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K10074/","notation":[{"@value":"KAKEN"}]}],"createdAt":"2020-04-28","modifiedAt":"2026-01-16","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=%E3%82%A4%E3%83%B3%E3%83%97%E3%83%A9%E3%83%B3%E3%83%88","dc:title":"インプラント"},{"@id":"https://cir.nii.ac.jp/all?q=%E9%AA%A8%E7%B2%97%E9%AC%86%E7%97%87","dc:title":"骨粗鬆症"},{"@id":"https://cir.nii.ac.jp/all?q=%E9%AA%A8%E7%B2%97%E9%AC%86%E7%97%87%E6%B2%BB%E7%99%82%E8%96%AC","dc:title":"骨粗鬆症治療薬"},{"@id":"https://cir.nii.ac.jp/all?q=%E9%AA%A8%E8%B3%AA","dc:title":"骨質"},{"@id":"https://cir.nii.ac.jp/all?q=%E9%AA%A8%E4%BB%A3%E8%AC%9D","dc:title":"骨代謝"},{"@id":"https://cir.nii.ac.jp/all?q=%E9%A1%8E%E9%AA%A8%E5%A3%8A%E6%AD%BB","dc:title":"顎骨壊死"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%82%A4%E3%83%B3%E3%83%97%E3%83%A9%E3%83%B3%E3%83%88%E5%91%A8%E5%9B%B2%E9%AA%A8","dc:title":"インプラント周囲骨"},{"@id":"https://cir.nii.ac.jp/all?q=%E9%AA%A8%E8%B3%AA%E5%8A%A3%E5%8C%96","dc:title":"骨質劣化"},{"@id":"https://cir.nii.ac.jp/all?q=%E9%AA%A8%E7%B4%B0%E8%83%9E","dc:title":"骨細胞"},{"@id":"https://cir.nii.ac.jp/all?q=%E9%A1%8E%E9%AA%A8","dc:title":"顎骨"},{"@id":"https://cir.nii.ac.jp/all?q=%E9%AA%A8%E8%B3%AA%E5%88%B6%E5%BE%A1","dc:title":"骨質制御"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%82%A4%E3%83%B3%E3%83%97%E3%83%A9%E3%83%B3%E3%83%88%E5%91%A8%E5%9B%B2%E9%AA%A8%E4%BB%A3%E8%AC%9D","dc:title":"インプラント周囲骨代謝"}],"product":[{"@id":"https://cir.nii.ac.jp/crid/1360576118806553216","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"DOI","@value":"10.1016/j.jmbbm.2021.104771"},{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S1751616121004148?httpAccept=text/xml"},{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S1751616121004148?httpAccept=text/plain"},{"@type":"PMID","@value":"34438251"}],"notation":[{"@value":"Influence of osteoporosis and mechanical loading on bone around osseointegrated dental implants: A rodent study"}]}],"dataSourceIdentifier":[{"@type":"KAKEN","@value":"20K10074"}],"grant":{"grantIdentifier":[{"@type":"NII","@value":"72"}],"jpcoar:fundingStream":[{"@language":"ja","@value":"基盤研究(C)"},{"@language":"en","@value":"Grant-in-Aid for Scientific Research (C)"}]},"allocationClassification":[{"notation":[{"@language":"ja","@value":"基金"},{"@language":"en","@value":"Multi-year Fund"}]}],"projectStatus":"project_closed","allocationAmount":{"totalCost":{"amount":"4290000","currency":"JPY"},"breakdownCost":[{"notation":[{"@language":"ja","@value":"直接経費"},{"@language":"en","@value":"Direct Cost"}],"amount":"3300000","currency":"JPY"},{"notation":[{"@language":"ja","@value":"間接経費"},{"@language":"en","@value":"Indirect Cost"}],"amount":"990000","currency":"JPY"}]}}