{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1040566775678996224.json","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"20K10107"},{"@type":"JGN","@value":"JP20K10107"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K10107/"}],"jpcoar:awardTitle":[{"@language":"ja","@value":"Wnt経路の新規下流シグナルの腺様嚢胞癌における機能解析と新規治療法の開発"},{"@language":"en","@value":"Functional analysis and development of novel adenoid cystic carcinoma therapy targeting Wnt signaling"}],"field":[{"keyword":[{"language":"ja","textList":["小区分57060:外科系歯学関連"]},{"language":"en","textList":["Basic Section 57060:Surgical dentistry-related"]}]}],"dc:language":"ja","description":[{"type":"outline_of_research_initial","notation":[{"@language":"ja","@value":"近年、唾液腺悪性腫瘍の腺様嚢胞癌におけるWnt/β-カテニン経路の異常活性化について報告された。Wnt/β-カテニン経路は主に遺伝子発現を制御するが、我々はWnt/β-カテニン経路の新たな下流因子Semaphorin3A（Sema3A）を同定し、Sema3Aによる細胞増殖制御を見出した。しかし、腺様嚢胞癌におけるSema3Aの意義は不明である。\n本研究では、Wnt/β-カテニン経路の新規下流因子Sema3Aの腺様嚢胞癌における役割の解明およびSema3Aシグナルを標的とした腺様嚢胞癌の新規治療法の開発を目的とする。これは、腺様嚢胞癌における新規分子基盤の解明と新規治療法開発のための基盤となる。"}]}],"researcher":[{"@id":"https://cir.nii.ac.jp/crid/1420564276165199744","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60452786"},{"@type":"NRID","@value":"1000060452786"},{"@type":"ORCID","@value":"0000-0001-8626-0193"},{"@type":"NRID","@value":"9000022205410"},{"@type":"NRID","@value":"9000237786848"},{"@type":"NRID","@value":"9000389001596"},{"@type":"NRID","@value":"9000004166738"},{"@type":"NRID","@value":"9000380969195"},{"@type":"NRID","@value":"9000409360004"},{"@type":"NRID","@value":"9000004233487"},{"@type":"NRID","@value":"9000378124572"},{"@type":"NRID","@value":"9000401543469"},{"@type":"NRID","@value":"9000414924414"},{"@type":"NRID","@value":"9000411026820"},{"@type":"NRID","@value":"9000401960553"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/812-8582"}],"foaf:name":[{"@language":"ja","@value":"藤井 慎介"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"九州大学"}],"role":"co_investigator_buntan"},{"@id":"https://cir.nii.ac.jp/crid/1420845751150026112","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30793989"},{"@type":"NRID","@value":"1000030793989"},{"@type":"NRID","@value":"9000411026822"}],"foaf:name":[{"@language":"ja","@value":"長谷川 佳那"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"九州大学"}],"role":"co_investigator_buntan"},{"@id":"https://cir.nii.ac.jp/crid/1420564276187959552","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70117224"},{"@type":"NRID","@value":"1000070117224"},{"@type":"NRID","@value":"9000259841400"},{"@type":"NRID","@value":"9000005535424"},{"@type":"NRID","@value":"9000256522526"},{"@type":"NRID","@value":"9000254946229"},{"@type":"NRID","@value":"9000263061857"},{"@type":"NRID","@value":"9000002607484"},{"@type":"NRID","@value":"9000364810968"},{"@type":"NRID","@value":"9000020679027"},{"@type":"NRID","@value":"9000020780758"},{"@type":"NRID","@value":"9000020728582"},{"@type":"NRID","@value":"9000020343024"},{"@type":"NRID","@value":"9000256580280"},{"@type":"NRID","@value":"9000258219910"},{"@type":"NRID","@value":"9000256583591"},{"@type":"NRID","@value":"9000255873210"},{"@type":"NRID","@value":"9000005531095"},{"@type":"NRID","@value":"9000020546840"},{"@type":"NRID","@value":"9000020481179"},{"@type":"NRID","@value":"9000242372431"},{"@type":"NRID","@value":"9000364814322"},{"@type":"NRID","@value":"9000255872046"},{"@type":"NRID","@value":"9000254619882"},{"@type":"NRID","@value":"9000401621574"},{"@type":"NRID","@value":"9000256584707"},{"@type":"NRID","@value":"9000256584631"},{"@type":"NRID","@value":"9000020367448"},{"@type":"NRID","@value":"9000020649910"},{"@type":"NRID","@value":"9000020387168"},{"@type":"NRID","@value":"9000283225208"},{"@type":"NRID","@value":"9000364814417"},{"@type":"NRID","@value":"9000020765215"},{"@type":"NRID","@value":"9000293506594"},{"@type":"NRID","@value":"9000020443585"},{"@type":"NRID","@value":"9000401580676"},{"@type":"NRID","@value":"9000020680880"},{"@type":"NRID","@value":"9000020678055"},{"@type":"NRID","@value":"9000267852042"},{"@type":"NRID","@value":"9000252943318"},{"@type":"NRID","@value":"9000254946411"},{"@type":"NRID","@value":"9000252763428"},{"@type":"NRID","@value":"9000254455325"}],"foaf:name":[{"@language":"ja","@value":"樋口 勝規"},{"@language":"en","@value":"Higuchi Yoshinori"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"福岡歯科大学"}],"role":"principal_investigator"},{"@id":"https://cir.nii.ac.jp/crid/1420564276182603776","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20264054"},{"@type":"NRID","@value":"1000020264054"},{"@type":"ORCID","@value":"0000-0002-5219-2652"},{"@type":"NRID","@value":"9000004728268"},{"@type":"NRID","@value":"9000260214549"},{"@type":"NRID","@value":"9000000764293"},{"@type":"NRID","@value":"9000410760333"},{"@type":"NRID","@value":"9000283357181"},{"@type":"NRID","@value":"9000020103608"},{"@type":"NRID","@value":"9000399008116"},{"@type":"NRID","@value":"9000411026830"},{"@type":"NRID","@value":"9000382051509"},{"@type":"NRID","@value":"9000413518227"},{"@type":"NRID","@value":"9000258076592"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/Tam-Kiyo5411906"}],"foaf:name":[{"@language":"ja","@value":"清島 保"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"九州大学"}],"role":"co_investigator_buntan"}],"since":"2020-04-01","until":"2023-03-31","institution":[{"institutionIdentifier":[{"@type":"NII","@value":"0037114"}],"notation":[{"@language":"ja","@value":"福岡歯科大学"},{"@language":"en","@value":"Fukuoka Dental College"}]}],"fundingProgram":[{"jpcoar:funderName":[{"@language":"ja","@value":"科学研究費助成事業"},{"@language":"en","@value":"Grants-in-Aid for Scientific 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