{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1040566775683437696.json","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"20K21681"},{"@type":"JGN","@value":"JP20K21681"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K21681/"}],"jpcoar:awardTitle":[{"@language":"ja","@value":"骨芽細胞分化能を指標とした骨代謝制御因子PRIPの阻害剤の探索"},{"@language":"en","@value":"Screening of compound library for inhibitors of PRIP"}],"field":[{"keyword":[{"language":"ja","textList":["中区分57:口腔科学およびその関連分野"]},{"language":"en","textList":["Medium-sized Section 57:Oral science and related fields"]}]}],"dc:language":"ja","description":[{"type":"outline_of_research_initial","notation":[{"@language":"ja","@value":"本研究では、骨芽細胞に分化誘導可能なマウス培養細胞株とGFPを用いた独自のスクリーニングシステムを用いて、化合物ライブラリーよりPRIPの阻害剤を選別する。絞り込んだ阻害剤候補について、マウスを用いてその効果および副作用を検討する。さらに、特定された阻害剤についてPRIPの組換えタンパク質を用いて生化学的解析を行い、作用機序を明らかにする。"}]}],"researcher":[{"@id":"https://cir.nii.ac.jp/crid/1420564276162660992","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"40291520"},{"@type":"NRID","@value":"1000040291520"},{"@type":"NRID","@value":"9000003160548"},{"@type":"NRID","@value":"9000020571325"},{"@type":"NRID","@value":"9000402097485"},{"@type":"NRID","@value":"9000020545236"},{"@type":"NRID","@value":"9000004730151"},{"@type":"NRID","@value":"9000006559027"},{"@type":"NRID","@value":"9000254961718"},{"@type":"NRID","@value":"9000018364600"},{"@type":"NRID","@value":"9000002262933"},{"@type":"NRID","@value":"9000006325993"},{"@type":"NRID","@value":"9000364816739"},{"@type":"NRID","@value":"9000383892130"},{"@type":"NRID","@value":"9000254494305"},{"@type":"NRID","@value":"9000004592382"},{"@type":"NRID","@value":"9000376926001"},{"@type":"NRID","@value":"9000255828848"},{"@type":"NRID","@value":"9000010751954"},{"@type":"NRID","@value":"9000018827333"},{"@type":"NRID","@value":"9000006349319"},{"@type":"NRID","@value":"9000283564242"},{"@type":"NRID","@value":"9000272994916"},{"@type":"NRID","@value":"9000380424720"},{"@type":"NRID","@value":"9000020221546"},{"@type":"NRID","@value":"9000020569099"},{"@type":"NRID","@value":"9000020495196"},{"@type":"NRID","@value":"9000256490442"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0189117"}],"foaf:name":[{"@language":"ja","@value":"松田 美穂"},{"@language":"en","@value":"Matsuda Miho"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"九州大学"}],"role":"principal_investigator"}],"since":"2020-07-30","until":"2023-03-31","institution":[{"institutionIdentifier":[{"@type":"NII","@value":"0017102"}],"notation":[{"@language":"ja","@value":"九州大学"},{"@language":"en","@value":"Kyushu University"}]}],"fundingProgram":[{"jpcoar:funderName":[{"@language":"ja","@value":"科学研究費助成事業"},{"@language":"en","@value":"Grants-in-Aid for Scientific Research"}]}],"url":[{"@id":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K21681/","notation":[{"@value":"KAKEN"}]}],"createdAt":"2020-08-03","modifiedAt":"2025-11-20","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=%E9%AA%A8%E8%8A%BD%E7%B4%B0%E8%83%9E%E5%88%86%E5%8C%96","dc:title":"骨芽細胞分化"},{"@id":"https://cir.nii.ac.jp/all?q=%E9%98%BB%E5%AE%B3%E5%89%A4","dc:title":"阻害剤"},{"@id":"https://cir.nii.ac.jp/all?q=PRIP","dc:title":"PRIP"},{"@id":"https://cir.nii.ac.jp/all?q=%E9%AA%A8%E8%8A%BD%E7%B4%B0%E8%83%9E","dc:title":"骨芽細胞"},{"@id":"https://cir.nii.ac.jp/all?q=%E5%88%86%E5%8C%96","dc:title":"分化"},{"@id":"https://cir.nii.ac.jp/all?q=%E9%98%BB%E5%AE%B3%E5%9B%A0%E5%AD%90","dc:title":"阻害因子"},{"@id":"https://cir.nii.ac.jp/all?q=%E9%AA%A8%E4%BB%A3%E8%AC%9D","dc:title":"骨代謝"}],"product":[{"@id":"https://cir.nii.ac.jp/crid/1010298668212895872","@type":"Article","resourceType":"学術雑誌論文(journal article)","notation":[{"@language":"ja","@value":"Inhibition of Non-Canonical NF-κB signaling suppresses periodontal inflammation and bone loss"}]},{"@id":"https://cir.nii.ac.jp/crid/1360013168787118848","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"DOI","@value":"10.1016/j.bone.2021.116210"},{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S8756328221003768?httpAccept=text/xml"},{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S8756328221003768?httpAccept=text/plain"},{"@type":"PMID","@value":"34592494"}],"notation":[{"@value":"Deletion of epithelial cell-specific p130Cas impairs the maturation stage of amelogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360857593741936512","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"DOI","@value":"10.1038/s41374-021-00661-y"},{"@type":"URI","@value":"https://www.nature.com/articles/s41374-021-00661-y.pdf"},{"@type":"URI","@value":"https://www.nature.com/articles/s41374-021-00661-y"},{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0023683722002872?httpAccept=text/xml"},{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0023683722002872?httpAccept=text/plain"},{"@type":"PMID","@value":"34504305"}],"notation":[{"@value":"Bone morphogenetic protein induces bone invasion of melanoma by epithelial–mesenchymal transition via the Smad1/5 signaling pathway"}]},{"@id":"https://cir.nii.ac.jp/crid/1360009142775037056","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"DOI","@value":"10.1016/j.jbc.2021.100274"},{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0021925821000417?httpAccept=text/xml"},{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0021925821000417?httpAccept=text/plain"},{"@type":"PMID","@value":"33428938"}],"notation":[{"@value":"Adipocyte-specific GPRC6A ablation promotes diet-induced obesity by inhibiting lipolysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360572092692753792","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"DOI","@value":"10.1016/j.ejphar.2021.173881"},{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0014299921000340?httpAccept=text/xml"},{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0014299921000340?httpAccept=text/plain"},{"@type":"PMID","@value":"33476655"}],"notation":[{"@value":"Volume-regulated chloride channel regulates cell proliferation and is involved in the possible interaction between TMEM16A and LRRC8A in human metastatic oral squamous cell carcinoma cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360568466645609472","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"DOI","@value":"10.1016/j.bone.2020.115316"},{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S875632822030096X?httpAccept=text/xml"},{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S875632822030096X?httpAccept=text/plain"},{"@type":"PMID","@value":"32169603"}],"notation":[{"@value":"A novel inhibitor of NF-κB-inducing kinase prevents bone loss by inhibiting osteoclastic bone resorption in ovariectomized mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360572092872044544","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"DOI","@value":"10.1038/s41374-020-00486-1"},{"@type":"URI","@value":"https://www.nature.com/articles/s41374-020-00486-1.pdf"},{"@type":"URI","@value":"https://www.nature.com/articles/s41374-020-00486-1"},{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0023683722003191?httpAccept=text/xml"},{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0023683722003191?httpAccept=text/plain"},{"@type":"PMID","@value":"32901097"}],"notation":[{"@value":"NFAT5 promotes oral squamous cell carcinoma progression in a hyperosmotic environment"}]}],"dataSourceIdentifier":[{"@type":"KAKEN","@value":"20K21681"}],"grant":{"grantIdentifier":[{"@type":"NII","@value":"250"}],"jpcoar:fundingStream":[{"@language":"ja","@value":"挑戦的研究(萌芽)"},{"@language":"en","@value":"Grant-in-Aid for Challenging Research (Exploratory)"}]},"allocationClassification":[{"notation":[{"@language":"ja","@value":"基金"},{"@language":"en","@value":"Multi-year Fund"}]}],"projectStatus":"project_closed","allocationAmount":{"totalCost":{"amount":"6500000","currency":"JPY"},"breakdownCost":[{"notation":[{"@language":"ja","@value":"直接経費"},{"@language":"en","@value":"Direct Cost"}],"amount":"5000000","currency":"JPY"},{"notation":[{"@language":"ja","@value":"間接経費"},{"@language":"en","@value":"Indirect Cost"}],"amount":"1500000","currency":"JPY"}]}}