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gliomas."}],"field":[{"keyword":[{"language":"ja","textList":["小区分56010:脳神経外科学関連"]},{"language":"en","textList":["Basic Section 56010:Neurosurgery-related"]}]}],"dc:language":"ja","description":[{"type":"outline_of_research_initial","notation":[{"@language":"ja","@value":"すでに、グリオーマ細胞株であるU251細胞株より、TMZ耐性の性質を有した細胞株を樹立培養し、基礎実験を行っている。オートファジーの阻害剤であるバフィロマイシン (BA) 存在下では、TMZ耐性が喪失することを見出した。BA存在下での生存率の低下は、耐性株のみで認められた。\nこれらは、グリオーマにおける、TMZ耐性獲得にオートファジーが関与していることを強く示唆する。よって、TMZ存在下でのオートファジー関連分子動向を詳細検討することで、TMZ耐性機序を明らかとする。"}]}],"researcher":[{"@id":"https://cir.nii.ac.jp/crid/1420564276175286912","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50550076"},{"@type":"NRID","@value":"1000050550076"},{"@type":"NRID","@value":"9000312255223"},{"@type":"NRID","@value":"9000018603100"},{"@type":"NRID","@value":"9000326661236"},{"@type":"NRID","@value":"9000003591426"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/hyonezawa"}],"foaf:name":[{"@language":"ja","@value":"米澤 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