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surgery-related"]}]}],"dc:language":"ja","description":[{"type":"outline_of_research_initial","notation":[{"@language":"ja","@value":"癌は免疫逃避により治療抵抗性を獲得しており、免疫逃避機構の一つがPD-L1とPD-1の結合によるT細胞の不活性化にある。PD-L1の発現量により治療効果に差が見られているが局所免疫環境には他の免疫機構も関わっており免疫逃避のメカニズム解明は食道癌治療において非常に重要であり新規治療法開発に向けてその研究の進展が期待されている。本研究の目的は食道癌における局所免疫の解明と革新的治療法への応用を検討することである。具体的には（１）食道癌における局所免疫環境の解明（２）食道癌の治療抵抗性獲得における免疫逃避の分子機構の解明（３）局所免疫環境を応用した食道癌の革新的治療の開発について詳細な検討を行う。"}]}],"researcher":[{"@id":"https://cir.nii.ac.jp/crid/1420564276160113664","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10828445"},{"@type":"NRID","@value":"1000010828445"}],"foaf:name":[{"@language":"ja","@value":"中ノ子 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