{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1040581301856239872.json","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23K24084"},{"@type":"JGN","@value":"JP23K24084"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K24084/"}],"jpcoar:awardTitle":[{"@language":"ja","@value":"新規パイエル板欠損マウスを用いた腸管関連リンパ組織形成の分子基盤の解明"},{"@language":"en","@value":"Elucidation of molecular basis of GALT formation using novel Peyer's patch deficient mice"}],"field":[{"keyword":[{"language":"ja","textList":["小区分48040:医化学関連"]},{"language":"en","textList":["Basic Section 48040:Medical biochemistry-related"]}]}],"dc:language":"ja","description":[{"type":"outline_of_research_initial","notation":[{"@language":"ja","@value":"100兆個に及ぶ腸内細菌が存在し病原体を含む微生物や食物由来の抗原に常に暴露されている腸管は、パイエル板をはじめとするGALTと呼ばれ る独自の粘膜免疫系が発達し、病原体の排除や腸内細菌の均衡維持を行う。このGALT形成は、特定の自然リンパ球と間葉系細胞の相互作用の重 要性以外殆ど分かっていない。そこで本研究では、PRIP欠損マウスにおけるGALT形成不全のメカニズムを解明し、GALT形成機構における新規分子基盤を導き出すことで、哺乳類のリンパ組織形成の新規メカニズムの解明を目指す。また、腸管免疫を起点とした腸-脳相関をはじめとする 多臓器間ネットワークの全容解明や様々な疾患の病態解明にも貢献する。"}]}],"researcher":[{"@id":"https://cir.nii.ac.jp/crid/1420564276162660992","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"40291520"},{"@type":"NRID","@value":"1000040291520"},{"@type":"NRID","@value":"9000003160548"},{"@type":"NRID","@value":"9000020571325"},{"@type":"NRID","@value":"9000402097485"},{"@type":"NRID","@value":"9000020545236"},{"@type":"NRID","@value":"9000004730151"},{"@type":"NRID","@value":"9000006559027"},{"@type":"NRID","@value":"9000254961718"},{"@type":"NRID","@value":"9000018364600"},{"@type":"NRID","@value":"9000002262933"},{"@type":"NRID","@value":"9000006325993"},{"@type":"NRID","@value":"9000364816739"},{"@type":"NRID","@value":"9000383892130"},{"@type":"NRID","@value":"9000254494305"},{"@type":"NRID","@value":"9000004592382"},{"@type":"NRID","@value":"9000376926001"},{"@type":"NRID","@value":"9000255828848"},{"@type":"NRID","@value":"9000010751954"},{"@type":"NRID","@value":"9000018827333"},{"@type":"NRID","@value":"9000006349319"},{"@type":"NRID","@value":"9000283564242"},{"@type":"NRID","@value":"9000272994916"},{"@type":"NRID","@value":"9000380424720"},{"@type":"NRID","@value":"9000020221546"},{"@type":"NRID","@value":"9000020569099"},{"@type":"NRID","@value":"9000020495196"},{"@type":"NRID","@value":"9000256490442"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0189117"}],"foaf:name":[{"@language":"ja","@value":"松田 美穂"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"九州大学"}],"role":"principal_investigator"}],"since":"2022-04-01","until":"2025-03-31","institution":[{"institutionIdentifier":[{"@type":"NII","@value":"0017102"}],"notation":[{"@language":"ja","@value":"九州大学"},{"@language":"en","@value":"Kyushu University"}]}],"fundingProgram":[{"jpcoar:funderName":[{"@language":"ja","@value":"科学研究費助成事業"},{"@language":"en","@value":"Grants-in-Aid for Scientific Research"}]}],"url":[{"@id":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K24084/","notation":[{"@value":"KAKEN"}]}],"createdAt":"2022-04-19","modifiedAt":"2025-11-20","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=GALT","dc:title":"GALT"},{"@id":"https://cir.nii.ac.jp/all?q=%E8%85%B8%E7%AE%A1%E5%85%8D%E7%96%AB","dc:title":"腸管免疫"},{"@id":"https://cir.nii.ac.jp/all?q=PRIP","dc:title":"PRIP"}],"dataSourceIdentifier":[{"@type":"KAKEN","@value":"23K24084"}],"grant":{"grantIdentifier":[{"@type":"NII","@value":"69"}],"jpcoar:fundingStream":[{"@language":"ja","@value":"基盤研究(B)"},{"@language":"en","@value":"Grant-in-Aid for Scientific Research (B)"}]},"allocationClassification":[{"notation":[{"@language":"ja","@value":"基金"},{"@language":"en","@value":"Multi-year Fund"}]},{"notation":[{"@language":"ja","@value":"補助金"},{"@language":"en","@value":"Single-year Grants"}]}],"projectStatus":"granted","allocationAmount":{"totalCost":{"amount":"17420000","currency":"JPY"},"breakdownCost":[{"notation":[{"@language":"ja","@value":"直接経費"},{"@language":"en","@value":"Direct Cost"}],"amount":"13400000","currency":"JPY"},{"notation":[{"@language":"ja","@value":"間接経費"},{"@language":"en","@value":"Indirect Cost"}],"amount":"4020000","currency":"JPY"}]}}