{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1040581301856721792.json","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23K25222"},{"@type":"JGN","@value":"JP23K25222"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K25222/"}],"jpcoar:awardTitle":[{"@language":"ja","@value":"機能性ナノ分子によるマクロファージ機能変換と慢性腎臓病の治療"},{"@language":"en","@value":"Treatment of chronic kidney disease (CKD) by a bioinspired nanomaterial modulating macrophage polarization"}],"field":[{"keyword":[{"language":"ja","textList":["小区分90120:生体材料学関連"]},{"language":"en","textList":["Basic Section 90120:Biomaterials-related"]}]}],"dc:language":"ja","description":[{"type":"outline_of_research_initial","notation":[{"@language":"ja","@value":"腎臓組織の炎症と線維化が惹起されて重症化すると、慢性腎臓病（chronic kidney disease: CKD）に至り、最悪の場合は末期腎不全に陥る。腎損傷部位に浸潤する炎症性M1型マクロファージは腎炎と腎線維化においてキーとなる細胞であり、慢性腎臓病の進行に深く関わっている。もし、炎症性M1型マクロファージを抗炎症・組織修復性M2型マクロファージに機能変換ができる手段が存在すれば、腎線維化の抑制と腎損傷部位の修復の両方が期待できる。本研究では、M1型からM2型に機能変換を可能とする機能性ナノ分子による腎炎と腎線維化の抑制および腎損傷部位の修復を評価し、CKDの治療剤としての可能性を探る。"}]}],"researcher":[{"@id":"https://cir.nii.ac.jp/crid/1420282801187331712","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50423512"},{"@type":"NRID","@value":"1000050423512"},{"@type":"NRID","@value":"9000018234690"},{"@type":"NRID","@value":"9000398137962"},{"@type":"NRID","@value":"9000406388015"},{"@type":"NRID","@value":"9000410015111"},{"@type":"NRID","@value":"9000380472335"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0118869"}],"foaf:name":[{"@language":"ja","@value":"姜 貞勲"},{"@language":"en","@value":"Kang 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