Comprehensive Synthesis of Truffle Alkaloids for the Elucidation of the Mechanism of Uric Acid Excretion

KAKEN

About This Project

Japan Grant Number
JP25K09895 (JGN)
Funding Program
Grants-in-Aid for Scientific Research
Funding Organization
Japan Society for the Promotion of Science

Kakenhi Information

Project/Area Number
25K09895
Research Category
Grant-in-Aid for Scientific Research (C)
Allocation Type
  • Multi-year Fund
Review Section / Research Field
  • Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
Research Institution
  • Kyushu University
Project Period (FY)
2025-04-01 〜 2028-03-31
Project Status
Granted
Budget Amount*help
4,680,000 Yen (Direct Cost: 3,600,000 Yen Indirect Cost: 1,080,000 Yen)

Research Abstract

トリュフから単離されたTuberindineは，既存薬と同等以上の尿酸血中濃度低下効果を示すためが，そのメカニズムは明らかではない。本研究では，Tuberindineの天然類縁体および人工誘導体の独自の系統的合成法を駆使して，作用機序解明に挑戦する。本研究は，新しいメカニズムに基づいて尿酸排泄機能を回復させる新治療薬の提供につながると期待される。

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