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Exploring synthetic lethality as a therapeutic target for refractory cancer
About This Project
- Japan Grant Number
- JP25H01058 (JGN)
- Funding Program
- Grants-in-Aid for Scientific Research
- Funding Organization
- Japan Society for the Promotion of Science
Kakenhi Information
- Project/Area Number
- 25H01058
- Research Category
- Grant-in-Aid for Scientific Research (A)
- Allocation Type
-
- Single-year Grants
- Review Section / Research Field
-
- Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
-
- Kyushu University
- Project Period (FY)
- 2025-04-01 〜 2028-03-31
- Project Status
- Granted
- Budget Amount*help
- 46,540,000 Yen (Direct Cost: 35,800,000 Yen Indirect Cost: 10,740,000 Yen)
Research Abstract
研究計画を通じて、genome-wide CRISPR/Cas9 dropout screening、Base-editor screening、分子生物学的手法は代表者の前田、分担者の平林、仙波が行う。マウスモデルの解析、臍帯血由来造血幹細胞、PDX、１細胞解析は、分担者の平林、仙波が行う。NK細胞の調製、NK細胞存在下でのスクリーニング、表面抗原解析は、分担者の米満、平林が行う。DELはWuXi社のDELopenを使用し、標的タンパクと化合物の結合はCETSAや、化合物存在下でのBESで評価する。
Keywords
Details 詳細情報について
-
- CRID
- 1040585407825660160
-
- Text Lang
- ja
-
- Data Source
-
- KAKEN