{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1040585407828291968.json","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"25K02286"},{"@type":"JGN","@value":"JP25K02286"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25K02286/"}],"jpcoar:awardTitle":[{"@language":"ja","@value":"核変形は内皮ー造血転換を駆動するリプログラミング因子か？"}],"field":[{"keyword":[{"language":"ja","textList":["小区分44020:発生生物学関連"]},{"language":"en","textList":["Basic Section 44020:Developmental biology-related"]}]}],"dc:language":"ja","description":[{"type":"outline_of_research_initial","notation":[{"@language":"ja","@value":"細胞群を人為的に初期化もしくは分化転換させるためには、特定の転写因子群を強制発現させる必要がある。一方、正常組織における細胞分化過程では、転写因子群自身も何らかの発現制御を受けているはずである。正常条件下において、細胞リプログラミングを引き起こす要因は何か？この疑問に答えるため、本研究では胚発生期に起こる細胞リプログラミング現象のひとつ、内皮－造血転換に焦点を当てる。内皮－造血転換中の細胞内では、一過的に形成される液胞からの圧力により核が変形する。血管内皮細胞から全く異なる性質をもつ造血幹細胞を生みだすしくみを理解するため、内皮－造血転換中の細胞内の変形核に対してエピゲノム解析を実施する。"}]}],"researcher":[{"@id":"https://cir.nii.ac.jp/crid/1420845751156405888","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"90508186"},{"@type":"NRID","@value":"1000090508186"},{"@type":"NRID","@value":"9000015664292"},{"@type":"NRID","@value":"9000025001812"},{"@type":"NRID","@value":"9000241643816"},{"@type":"NRID","@value":"9000014216556"},{"@type":"NRID","@value":"9000248226647"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/7000018594"}],"foaf:name":[{"@language":"ja","@value":"佐藤 有紀"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"九州大学"}],"role":"principal_investigator"}],"since":"2025-04-01","until":"2029-03-31","institution":[{"institutionIdentifier":[{"@type":"NII","@value":"0017102"}],"notation":[{"@language":"ja","@value":"九州大学"},{"@language":"en","@value":"Kyushu University"}]}],"fundingProgram":[{"jpcoar:funderName":[{"@language":"ja","@value":"科学研究費助成事業"},{"@language":"en","@value":"Grants-in-Aid for Scientific Research"}]}],"url":[{"@id":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25K02286/","notation":[{"@value":"KAKEN"}]}],"createdAt":"2025-04-17","modifiedAt":"2025-06-20","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=%E5%86%85%E7%9A%AE%EF%BC%8D%E9%80%A0%E8%A1%80%E8%BB%A2%E6%8F%9B","dc:title":"内皮－造血転換"},{"@id":"https://cir.nii.ac.jp/all?q=%E6%A0%B8%E5%A4%89%E5%BD%A2","dc:title":"核変形"},{"@id":"https://cir.nii.ac.jp/all?q=%E6%B6%B2%E8%83%9E","dc:title":"液胞"}],"dataSourceIdentifier":[{"@type":"KAKEN","@value":"25K02286"}],"grant":{"grantIdentifier":[{"@type":"NII","@value":"69"}],"jpcoar:fundingStream":[{"@language":"ja","@value":"基盤研究(B)"},{"@language":"en","@value":"Grant-in-Aid for Scientific Research (B)"}]},"allocationClassification":[{"notation":[{"@language":"ja","@value":"基金"},{"@language":"en","@value":"Multi-year Fund"}]}],"projectStatus":"granted","allocationAmount":{"totalCost":{"amount":"18850000","currency":"JPY"},"breakdownCost":[{"notation":[{"@language":"ja","@value":"直接経費"},{"@language":"en","@value":"Direct Cost"}],"amount":"14500000","currency":"JPY"},{"notation":[{"@language":"ja","@value":"間接経費"},{"@language":"en","@value":"Indirect Cost"}],"amount":"4350000","currency":"JPY"}]}}