{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1040848250655764608.json","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"20K10207"},{"@type":"JGN","@value":"JP20K10207"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K10207/"}],"jpcoar:awardTitle":[{"@language":"ja","@value":"Mechanosensitive microRNAによる下顎骨成長制御メカニズム"},{"@language":"en","@value":"Mechanisms of growth of mandibular condylar cartilage by mechanosensitive microRNA"}],"field":[{"keyword":[{"language":"ja","textList":["小区分57070:成長および発育系歯学関連"]},{"language":"en","textList":["Basic Section 57070:Developmental dentistry-related"]}]}],"dc:language":"ja","description":[{"type":"outline_of_research_initial","notation":[{"@language":"ja","@value":"顎顔面骨格の成長発育を制御することは、成長期の矯正歯科治療の最も重要な治療の目標であり、この達成は、成長期以降の正常咬合獲得に大きく貢献する。これまでに申請者らは網羅的解析により、メカニカルストレス応答性を有する mechanosensitive miRNA 候補を見いだした。これら miRNA は、下顎頭軟骨において特異的に働き、 軟骨細胞の分化制御を担っている可能性がある。本研究では、下顎頭軟骨細胞の分化および下顎頭軟骨の成長発育過程におけるメカニカルストレス応答性のmiRNAとしてmechanosensitive miRNAの働きを解明することを目的とした。"}]}],"researcher":[{"@id":"https://cir.nii.ac.jp/crid/1420564276170781440","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10510018"},{"@type":"NRID","@value":"1000010510018"},{"@type":"NRID","@value":"9000021266041"}],"foaf:name":[{"@language":"ja","@value":"寺尾 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一郎"},{"@language":"en","@value":"Takahashi Ichiro"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"九州大学"}],"role":"principal_investigator"}],"since":"2020-04-01","until":"2023-03-31","institution":[{"institutionIdentifier":[{"@type":"NII","@value":"0017102"}],"notation":[{"@language":"ja","@value":"九州大学"},{"@language":"en","@value":"Kyushu University"}]}],"fundingProgram":[{"jpcoar:funderName":[{"@language":"ja","@value":"科学研究費助成事業"},{"@language":"en","@value":"Grants-in-Aid for Scientific Research"}]}],"url":[{"@id":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K10207/","notation":[{"@value":"KAKEN"}]}],"createdAt":"2020-04-28","modifiedAt":"2025-11-20","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=mechanosensitive%20miRNA","dc:title":"mechanosensitive 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