{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1040850857184396032.json","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"21H02118"},{"@type":"JGN","@value":"JP21H02118"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H02118/"}],"jpcoar:awardTitle":[{"@language":"ja","@value":"スフィンゴ脂質代謝異常下で細胞救済に寄与するシグナリング機構の解明"},{"@language":"en","@value":"Elucidation of the signaling mechanism that contributes to cell rescue under abnormal sphingolipid metabolism"}],"field":[{"keyword":[{"language":"ja","textList":["小区分38030:応用生物化学関連"]},{"language":"en","textList":["Basic Section 38030:Applied biochemistry-related"]}]}],"dc:language":"ja","description":[{"type":"outline_of_research_initial","notation":[{"@language":"ja","@value":"複合スフィンゴ脂質は、真核生物の生体膜の機能維持において要となる分子であり、その代謝異常は多岐に渡る細胞機能異常を引き起こす。申請者らは最近、出芽酵母において「細胞内の複合スフィンゴ脂質の減少に対し、特定のシグナル系 (HOG経路)が活性化されることで生き延びる救済機構が存在する」ことを見出した。本研究では、このようなシグナリング機構の全容解明を試み、スフィンゴ脂質の代謝異常による細胞機能の損傷とその修復に関して、新しい切り口から研究を展開する。"}]}],"researcher":[{"@id":"https://cir.nii.ac.jp/crid/1420001326218395136","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20452740"},{"@type":"NRID","@value":"1000020452740"},{"@type":"ORCID","@value":"0000-0003-4316-8260"},{"@type":"NRID","@value":"9000001294141"},{"@type":"NRID","@value":"9000410606914"},{"@type":"NRID","@value":"9000018562264"},{"@type":"NRID","@value":"9000345302182"},{"@type":"NRID","@value":"9000356684006"},{"@type":"NRID","@value":"9000000366212"},{"@type":"NRID","@value":"9000414939820"},{"@type":"NRID","@value":"9000014204172"},{"@type":"NRID","@value":"9000263035607"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0134181"}],"foaf:name":[{"@language":"ja","@value":"谷 元洋"},{"@language":"en","@value":"Tani Motohiro"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"岐阜大学"}],"role":"principal_investigator"},{"@id":"https://cir.nii.ac.jp/crid/1420282801214075392","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"90572868"},{"@type":"NRID","@value":"1000090572868"},{"@type":"ORCID","@value":"0000-0002-9657-8207"},{"@type":"NRID","@value":"9000345302327"},{"@type":"NRID","@value":"9000305637960"},{"@type":"NRID","@value":"9000305637965"}],"foaf:name":[{"@language":"ja","@value":"石橋 洋平"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"九州大学"}],"role":"co_investigator_buntan"}],"since":"2021-04-01","until":"2024-03-31","institution":[{"institutionIdentifier":[{"@type":"NII","@value":"0013701"}],"notation":[{"@language":"ja","@value":"岐阜大学"},{"@language":"en","@value":"Gifu University"}]},{"institutionIdentifier":[{"@type":"NII","@value":"0017102"}],"notation":[{"@language":"ja","@value":"九州大学"},{"@language":"en","@value":"Kyushu University"}]}],"fundingProgram":[{"jpcoar:funderName":[{"@language":"ja","@value":"科学研究費助成事業"},{"@language":"en","@value":"Grants-in-Aid for Scientific Research"}]}],"url":[{"@id":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H02118/","notation":[{"@value":"KAKEN"}]}],"createdAt":"2021-04-28","modifiedAt":"2025-11-20","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=%E3%82%B9%E3%83%95%E3%82%A3%E3%83%B3%E3%82%B4%E8%84%82%E8%B3%AA","dc:title":"スフィンゴ脂質"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%82%BB%E3%83%A9%E3%83%9F%E3%83%89","dc:title":"セラミド"},{"@id":"https://cir.nii.ac.jp/all?q=%E8%A4%87%E5%90%88%E3%82%B9%E3%83%95%E3%82%A3%E3%83%B3%E3%82%B4%E8%84%82%E8%B3%AA","dc:title":"複合スフィンゴ脂質"},{"@id":"https://cir.nii.ac.jp/all?q=%E6%95%91%E6%B8%88%E6%A9%9F%E6%A7%8B","dc:title":"救済機構"},{"@id":"https://cir.nii.ac.jp/all?q=%E5%87%BA%E8%8A%BD%E9%85%B5%E6%AF%8D","dc:title":"出芽酵母"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%82%B7%E3%82%B0%E3%83%8A%E3%83%AB%E4%BC%9D%E9%81%94%E7%B3%BB","dc:title":"シグナル伝達系"}],"product":[{"@id":"https://cir.nii.ac.jp/crid/1360022307171367552","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"DOI","@value":"10.21203/rs.3.rs-2746599/v1"},{"@type":"URI","@value":"https://www.researchsquare.com/article/rs-2746599/v1"},{"@type":"URI","@value":"https://www.researchsquare.com/article/rs-2746599/v1.html"},{"@type":"DOI","@value":"10.1038/s41598-023-38237-z"},{"@type":"URI","@value":"https://www.nature.com/articles/s41598-023-38237-z.pdf"},{"@type":"URI","@value":"https://www.nature.com/articles/s41598-023-38237-z"},{"@type":"PMID","@value":"37429938"}],"notation":[{"@value":"Impaired biosynthesis of ergosterol confers resistance to complex sphingolipid biosynthesis inhibitor aureobasidin A in a PDR16-dependent manner"}]},{"@id":"https://cir.nii.ac.jp/crid/1050300755726244736","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"HDL","@value":"http://hdl.handle.net/2237/0002011245"},{"@type":"URI","@value":"https://nagoya.repo.nii.ac.jp/records/2011245"},{"@type":"DOI","@value":"10.1007/s00438-024-02107-8"},{"@type":"URI","@value":"https://link.springer.com/content/pdf/10.1007/s00438-024-02107-8.pdf"},{"@type":"URI","@value":"https://link.springer.com/article/10.1007/s00438-024-02107-8/fulltext.html"}],"notation":[{"@language":"en","@value":"Identification of plb1 mutation that extends longevity via activating Sty1 MAPK in Schizosaccharomyces pombe"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298336559190912","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"DOI","@value":"10.1016/j.bbrc.2022.03.061"},{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0006291X22003928?httpAccept=text/xml"},{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0006291X22003928?httpAccept=text/plain"},{"@type":"PMID","@value":"35316765"}],"notation":[{"@value":"Involvement of the mitochondrial retrograde pathway in dihydrosphingosine-induced cytotoxicity in budding yeast"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298755643086464","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"DOI","@value":"10.1091/mbc.e22-04-0117"},{"@type":"PMID","@value":"35895092"}],"notation":[{"@value":"Loss of tolerance to multiple environmental stresses due to limitation of structural diversity of complex sphingolipids"}]},{"@id":"https://cir.nii.ac.jp/crid/1360013168868710016","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"DOI","@value":"10.1111/febs.16188"},{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/febs.16188"},{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/febs.16188"},{"@type":"URI","@value":"https://febs.onlinelibrary.wiley.com/doi/pdf/10.1111/febs.16188"},{"@type":"PMID","@value":"34492172"}],"notation":[{"@value":"Crosstalk between protein kinase A and the HOG pathway under impaired biosynthesis of complex sphingolipids in budding yeast"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294643779382144","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"DOI","@value":"10.1111/febs.16189"},{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/febs.16189"},{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/febs.16189"},{"@type":"URI","@value":"https://febs.onlinelibrary.wiley.com/doi/pdf/10.1111/febs.16189"},{"@type":"PMID","@value":"34492164"}],"notation":[{"@value":"Regulation of sphingolipid biosynthesis in the endoplasmic reticulum via signals from the plasma membrane in budding yeast"}]},{"@id":"https://cir.nii.ac.jp/crid/1050853719958932608","@type":"Article","resourceType":"学術雑誌論文(journal article)","productIdentifier":[{"@type":"HDL","@value":"http://hdl.handle.net/2237/0002001897"},{"@type":"URI","@value":"https://nagoya.repo.nii.ac.jp/records/2001897"},{"@type":"DOI","@value":"10.1093/femsle/fnab070"},{"@type":"URI","@value":"http://academic.oup.com/femsle/advance-article-pdf/doi/10.1093/femsle/fnab070/38596473/fnab070.pdf"},{"@type":"URI","@value":"http://academic.oup.com/femsle/article-pdf/368/12/fnab070/40343310/fnab070.pdf"},{"@type":"PMID","@value":"34114004"},{"@type":"NAID","@value":"120007183219"}],"notation":[{"@language":"en","@value":"Identification of sur2 mutation affecting the lifespan of fission yeast"},{"@value":"Identification of <i>sur2</i> mutation affecting the lifespan of fission yeast"}]},{"@id":"https://cir.nii.ac.jp/crid/1010294643578101760","@type":"Article","resourceType":"学術雑誌論文(journal article)","notation":[{"@language":"ja","@value":"複合スフィンゴ脂質破綻から細胞を守る救済機構"}]},{"@id":"https://cir.nii.ac.jp/crid/1971993809758600595","@type":"Book","resourceType":"図書(book)","productIdentifier":[{"@type":"NCID","@value":"BD02498054"},{"@type":"ISBN","@value":"9784781317403"},{"@type":"URI","@value":"https://ci.nii.ac.jp/ncid/BD02498054#entity"}],"notation":[{"@language":"ja","@value":"微生物を活用した有用物質の製造技術"},{"@language":"ja-Kana","@value":"ビセイブツ オ カツヨウシタ ユウヨウ ブッシツ ノ セイゾウ ギジュツ"}]}],"dataSourceIdentifier":[{"@type":"KAKEN","@value":"21H02118"}],"grant":{"grantIdentifier":[{"@type":"NII","@value":"69"}],"jpcoar:fundingStream":[{"@language":"ja","@value":"基盤研究(B)"},{"@language":"en","@value":"Grant-in-Aid for Scientific Research (B)"}]},"allocationClassification":[{"notation":[{"@language":"ja","@value":"補助金"},{"@language":"en","@value":"Single-year Grants"}]}],"projectStatus":"project_closed","allocationAmount":{"totalCost":{"amount":"17680000","currency":"JPY"},"breakdownCost":[{"notation":[{"@language":"ja","@value":"直接経費"},{"@language":"en","@value":"Direct Cost"}],"amount":"13600000","currency":"JPY"},{"notation":[{"@language":"ja","@value":"間接経費"},{"@language":"en","@value":"Indirect Cost"}],"amount":"4080000","currency":"JPY"}]}}