{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1050001201939488640.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"HDL","@value":"http://hdl.handle.net/2433/115101"}},{"identifier":{"@type":"NAID","@value":"120002142560"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2004129639"}}],"resourceType":"紀要論文(departmental bulletin paper)","dc:title":[{"@language":"ja","@value":"ヒト膀胱平滑筋細胞の形態学的Phenotypeの検討"},{"@language":"en","@value":"Phenotypic changes in human bladder smooth muscle cell"}],"dc:language":"ja","description":[{"type":"Abstract","notation":[{"@language":"ja","@value":"1999～2000年までの2年間に膀胱疾患に対して手術加療され, 膀胱の一部分, または全摘出した症例のうち, 膀胱体部の標本を一部本研究に提供することに同意を得た15例(男11例, 女4例, 年齢7～82歳, 平均52.1歳)を対象にした.基礎疾患は神経因性膀胱(NgB)2例, 慢性腎不全6例, 前立腺肥大症3例, 膀胱癌(BT)3例, 膀胱尿道逆流症1例であった.ヒト膀胱平滑筋細胞の形態学的phenotypeについて検討した結果, ヒト膀胱平滑筋細胞においても血管平滑筋細胞と同様にphenotypeという概念を用いて分類することが可能であった.膀胱において筋層内の線維化とphenotypeの比率に関連を認めなかった.また, NgBなどの病的膀胱には合成型phenotypeが優位で, 収縮型から非収縮型へ膀胱平滑筋細胞のphenotypeが形質変換しており, このphenotypeの調節が排尿筋機能に重要な役割を果たしていると思われた.線維化や収縮能のマーカーと成り得る可能性が示唆された"}]},{"type":"Abstract","notation":[{"@language":"en","@value":"Tissue specimens were resected from 15 patients (age 7 to 82, average 52.2 years old) with bladder diseases; i.e., 2 with neurogenic bladder, 6 recipients of kidney transplantation with defunctionalized bladder, 3 with benign prostatic hypertrophy, 3 with bladder cancer and 1 with vesicoureteral reflux. We investigated the phenotypic expression of the bladder smooth muscle cells with bladder diseases. The ratio of non-contractile to contractile phenotypes (nc/c ratio) showed a rising tendency with aging. The increase of nc/c ratio was especially notable with neurogenic bladder. Phenotypic expression was observed in human bladder smooth muscle cells as reported in vascular smooth muscle cells. Several bladder diseases cause a conversion of contractile smooth muscle cell phenotype from contractile type to non-contractile type, and this modulation of smooth muscle cell phenotype may play an important role in detrusor function."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420564276170402816","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10288912"},{"@type":"NRID","@value":"1000010288912"},{"@type":"NRID","@value":"9000398260760"},{"@type":"NRID","@value":"9000314075983"},{"@type":"NRID","@value":"9000327099629"},{"@type":"NRID","@value":"9000024340219"},{"@type":"NRID","@value":"9000024301208"},{"@type":"NRID","@value":"9000023503718"},{"@type":"NRID","@value":"9000023595172"},{"@type":"NRID","@value":"9000255315688"},{"@type":"NRID","@value":"9000006775898"},{"@type":"NRID","@value":"9000329005070"},{"@type":"NRID","@value":"9000390874660"},{"@type":"NRID","@value":"9000023574751"},{"@type":"NRID","@value":"9000310000089"},{"@type":"NRID","@value":"9000387396530"},{"@type":"NRID","@value":"9000327100467"},{"@type":"NRID","@value":"9000310735165"},{"@type":"NRID","@value":"9000322108074"},{"@type":"NRID","@value":"9000240261027"},{"@type":"NRID","@value":"9000331445673"},{"@type":"NRID","@value":"9000345303490"},{"@type":"NRID","@value":"9000024329054"},{"@type":"NRID","@value":"9000375921702"},{"@type":"NRID","@value":"9000391670544"},{"@type":"NRID","@value":"9000313199101"},{"@type":"NRID","@value":"9000340950579"},{"@type":"NRID","@value":"9000258230200"},{"@type":"NRID","@value":"9000240261029"},{"@type":"NRID","@value":"9000398149901"},{"@type":"NRID","@value":"9000023550017"},{"@type":"NRID","@value":"9000023624944"},{"@type":"NRID","@value":"9000331445685"},{"@type":"NRID","@value":"9000356514210"},{"@type":"NRID","@value":"9000310734838"},{"@type":"NRID","@value":"9000024345728"},{"@type":"NRID","@value":"9000367020233"},{"@type":"NRID","@value":"9000237808420"},{"@type":"NRID","@value":"9000398155932"},{"@type":"NRID","@value":"9000356479024"},{"@type":"NRID","@value":"9000388461689"},{"@type":"NRID","@value":"9000023669310"},{"@type":"NRID","@value":"9000323290855"},{"@type":"NRID","@value":"9000325830979"},{"@type":"NRID","@value":"9000345397189"}],"foaf:name":[{"@language":"ja","@value":"松本, 成史"},{"@language":"en","@value":"Matsumoto, Seiji"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"近畿大学 医学部泌尿器科"},{"@language":"en","@value":"Department of Urology, Kinki University School of Medicine."}]},{"@id":"https://cir.nii.ac.jp/crid/1030566608415826817","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00288911"},{"@type":"NRID","@value":"1000000288911"},{"@type":"NRID","@value":"9000016836065"},{"@type":"NRID","@value":"9000024340221"},{"@type":"NRID","@value":"9000340954567"},{"@type":"NRID","@value":"9000002201563"},{"@type":"NRID","@value":"9000023528686"},{"@type":"NRID","@value":"9000016905883"},{"@type":"NRID","@value":"9000024352018"},{"@type":"NRID","@value":"9000023669305"}],"foaf:name":[{"@language":"ja","@value":"花井, 禎"},{"@language":"en","@value":"Hanai, Tadashi"}]},{"@id":"https://cir.nii.ac.jp/crid/1070001201939488640","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000024340226"}],"foaf:name":[{"@language":"ja","@value":"栗田, 孝"},{"@language":"en","@value":"Kurita, Takashi"}]},{"@id":"https://cir.nii.ac.jp/crid/1070001201939488643","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000024340230"}],"foaf:name":[{"@language":"ja","@value":"秋山, 隆弘"},{"@language":"en","@value":"Akiyama, Takahiro"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00181994"},{"@type":"NCID","@value":"AN00208315"}],"prism:publicationName":[{"@language":"ja","@value":"泌尿器科紀要"},{"@language":"la","@value":"Acta urologica Japonica"},{"@language":"en","@value":"Hinyokika Kiyo"}],"dc:publisher":[{"@value":"泌尿器科紀要刊行会"}],"prism:publicationDate":"2003-12","prism:volume":"49","prism:number":"12","prism:startingPage":"715","prism:endingPage":"719"},"dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"http://hdl.handle.net/2433/115101"},{"@id":"https://search.jamas.or.jp/link/ui/2004129639"}],"foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Adolescent","dc:title":"Adolescent"},{"@id":"https://cir.nii.ac.jp/all?q=Adult","dc:title":"Adult"},{"@id":"https://cir.nii.ac.jp/all?q=Aged","dc:title":"Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Aged,%2080%20and%20over","dc:title":"Aged, 80 and over"},{"@id":"https://cir.nii.ac.jp/all?q=Child","dc:title":"Child"},{"@id":"https://cir.nii.ac.jp/all?q=Contractile%20Proteins/metabolism","dc:title":"Contractile Proteins/metabolism"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Middle%20Aged","dc:title":"Middle Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Muscle,%20Smooth/cytology","dc:title":"Muscle, Smooth/cytology"},{"@id":"https://cir.nii.ac.jp/all?q=Phenotype","dc:title":"Phenotype"},{"@id":"https://cir.nii.ac.jp/all?q=Prostatic%20Hyperplasia/pathology","dc:title":"Prostatic Hyperplasia/pathology"},{"@id":"https://cir.nii.ac.jp/all?q=Urinary%20Bladder/cytology","dc:title":"Urinary Bladder/cytology"},{"@id":"https://cir.nii.ac.jp/all?q=Urinary%20Bladder%20Diseases/genetics/pathology","dc:title":"Urinary Bladder Diseases/genetics/pathology"},{"@id":"https://cir.nii.ac.jp/all?q=Urinary%20Bladder%20Neoplasms/pathology","dc:title":"Urinary Bladder Neoplasms/pathology"},{"@id":"https://cir.nii.ac.jp/all?q=Urinary%20Bladder,%20Neurogenic/pathology","dc:title":"Urinary Bladder, Neurogenic/pathology"}],"dcterms:subject":[{"subjectScheme":"Other","notation":[{"@language":"en","@value":"Adolescent"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"Adult"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"Aged"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"Aged, 80 and over"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"Child"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"Contractile Proteins/metabolism"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"Female"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"Humans"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"Male"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"Middle Aged"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"Muscle, Smooth/cytology"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"Phenotype"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"Prostatic Hyperplasia/pathology"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"Urinary Bladder/cytology"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"Urinary Bladder Diseases/genetics/pathology"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"Urinary Bladder Neoplasms/pathology"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"Urinary Bladder, Neurogenic/pathology"}]},{"subjectScheme":"NDC","notation":[{"@value":"494.9"}]}],"dataSourceIdentifier":[{"@type":"IRDB","@value":"oai:irdb.nii.ac.jp:01221:0000080524"},{"@type":"CIA","@value":"120002142560"}]}