{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1050001202064217728.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"HDL","@value":"http://hdl.handle.net/2433/108607"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"6409267"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/6409267"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I6409267"}},{"identifier":{"@type":"URI","@value":"https://dl.ndl.go.jp/pid/10864155"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"10864155"}},{"identifier":{"@type":"NAID","@value":"110003371989"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/digimeta/10864155"}},{"identifier":{"@type":"DOI","@value":"10.2108/zsj.18.833"}},{"identifier":{"@type":"URI","@value":"http://www.bioone.org/doi/pdf/10.2108/zsj.18.833"}},{"identifier":{"@type":"URI","@value":"http://dl.ndl.go.jp/info:ndljp/pid/10864155"}},{"identifier":{"@type":"HANDLE","@value":"2433/108607"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Expression Patterns of Smad Family Members during Embryogenesis of the Ascidian Halocynthia roretzi"},{"@value":"Expression Patterns of Smad Family Members during Embryogenesis of the Ascidian Halocynthia roretzi(Developmental Biology)"}],"dc:language":"en","description":[{"type":"Abstract","notation":[{"@language":"en","@value":"The ascidian embryo has been long thought to show a mosaic mode of development. However, recent studies revealed significance of cell-cell communication during cleavage stages of embryogenesis. FGF and BMP signalings play critical roles in determination of cell types. Little is, however, known about regulation of competence of cells to the signals. Here we report the isolation of ascidian smad genes; Hrsmad4 which encodes a homolog of smad4 of vertebrates, Hrsmad6/7 which encodes a homologous gene of smad 6 and smad7 of vertebrates, and Hrsmad2/3 which encodes a homolog of smad2 and smad3 of vertebrates. The mRNAs of the isolated smad family genes were maternally inherited in egg and early embryos. While Hrsmad4 and Hrsmad6/7 RNAs distributed broadly in the early embryos, Hrsmad2/3 RNA was preferentially accumulated in the animal hemisphere."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420564276168105600","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"90225491"},{"@type":"NRID","@value":"1000090225491"},{"@type":"NRID","@value":"9000409979501"},{"@type":"NRID","@value":"9000411236776"},{"@type":"NRID","@value":"9000411988685"},{"@type":"NRID","@value":"9000412685543"},{"@type":"NRID","@value":"9000411387120"},{"@type":"NRID","@value":"9000412236643"},{"@type":"NRID","@value":"9000413383196"},{"@type":"NRID","@value":"9000411641673"},{"@type":"NRID","@value":"9000412380152"},{"@type":"NRID","@value":"9000410469720"},{"@type":"NRID","@value":"9000414262235"},{"@type":"NRID","@value":"9000410962023"},{"@type":"NRID","@value":"9000410631714"},{"@type":"NRID","@value":"9000364724135"},{"@type":"NRID","@value":"9000413940494"},{"@type":"NRID","@value":"9000413733469"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0019311215"}],"foaf:name":[{"@language":"en","@value":"Kobayashi, Ako"}]},{"@id":"https://cir.nii.ac.jp/crid/1070001202064217729","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000364703962"}],"foaf:name":[{"@language":"en","@value":"Makabe, Kazuhiro W."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"02890003"},{"@type":"NDL_BIB_ID","@value":"000000131434"},{"@type":"ISSN","@value":"02890003"},{"@type":"NCID","@value":"AA10545874"}],"prism:publicationName":[{"@language":"en","@value":"Zoological Science"}],"dc:publisher":[{"@value":"Zoological Society of Japan"},{"@value":"日本動物学会"}],"prism:publicationDate":"2001-08","prism:volume":"18","prism:number":"6","prism:startingPage":"833","prism:endingPage":"842"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["(c) 日本動物学会 / Zoological Society of Japan"],"url":[{"@id":"http://id.ndl.go.jp/bib/6409267"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I6409267"},{"@id":"https://dl.ndl.go.jp/pid/10864155"},{"@id":"http://id.ndl.go.jp/digimeta/10864155"},{"@id":"http://www.bioone.org/doi/pdf/10.2108/zsj.18.833"},{"@id":"http://dl.ndl.go.jp/info:ndljp/pid/10864155"},{"@id":"http://hdl.handle.net/2433/108607"},{"@id":"http://joi.jlc.jst.go.jp/JST.JSTAGE/zsj/18.833?from=CiNii"}],"foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Animal%20Science%20and%20Zoology","dc:title":"Animal Science and Zoology"}],"dcterms:subject":[{"subjectScheme":"NDC","notation":[{"@value":"480"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011145740740352","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Identification of Two Smad4 Proteins in Xenopus"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145798666496","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Expression of a Gene for Major Mitochondrial Protein, ADP/ATP Translocase, during Embryogenesis in the Ascidian <i>Halocynthia roretzi</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145821010560","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619092613760","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Regulation of transforming growth factor β- and activin-induced transcription by mammalian Mad proteins"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619159416960","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"EMBRYONIC INDUCTION IN THE ASCIDIA"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619483026432","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Confidence Limits on Phylogenies: An Approach Using the 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<i>Bmp-2/Bmp-4</i> suggests its role in the inhibition of neural fate specification"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520066272768","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Genomic structure of the human Smad3 gene and its infrequent alterations in colorectal cancers"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418521365949568","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Basic fibroblast growth factor induces notochord formation and the expression of <i>As-T</i>, a <i>Brachyury</i> homolog, during ascidian embryogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699993988722688","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Receptor-associated Mad homologues synergize as effectors of the TGF-β response"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994226737152","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Timing of initiation of muscle‐specific gene expression in the ascidian embryo precedes that of developmental fate restriction in lineage cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994471092480","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"MAD-related proteins in TGF-β signalling"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995683076736","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"An ascidian homologue of vertebrate BMPs-5–8 is expressed in the midline of the anterior neuroectoderm and in the midline of the ventral epidermis of the embryo"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469623390464","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Xenopus Mad Proteins Transduce Distinct Subsets of Signals for the TGFβ Superfamily"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470814237440","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway."}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470825668992","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"An FGF signal from endoderm and localized factors in the posterior-vegetal egg cytoplasm pattern the mesodermal tissues in the ascidian embryo"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262943981911424","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Characterization of a Novel Member of the FGFR Family, HrFGFR, in Halocynthia roretzi"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944087209344","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Sequence and chromosomal mapping of the mouse homolog (Madh4) of the human DPC4/MADH4 gene"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944340272128","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The <i>Drosophila</i> Activin receptor Baboon signals through dSmad2 and controls cell proliferation but not patterning during larval development"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945481236224","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase."}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419091769088","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"MADR2 Maps to 18q21 and Encodes a TGFβ–Regulated MAD–Related Protein That Is Functionally Mutated in Colorectal Carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544421317398912","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894194945280","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster."}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368894352384","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843263411712","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Induction of brain and sensory pigment cells in the ascidian embryo analyzed by experiments with isolated blastomeres"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844275317248","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844591259392","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"<i>Medea</i> is a Drosophila <i>Smad4</i> homolog that is differentially required to potentiate DPP responses"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844699153024","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Daughters against dpp modulates dpp organizing activity in Drosophila wing development"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844929141760","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Smad6 inhibits signalling by the TGF-β superfamily"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319850825600","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cell Fate Specification by Localized Cytoplasmic Determinants and Cell Interactions in Ascidian Embryos"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320003558656","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth."}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793208807936","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"A maternal RNA encoding <i>smad1/5</i> is segregated to animal blastomeres during ascidian development"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795066200320","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Induction of Notochord during Ascidian Embryogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269033397248","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"MADR1, a MAD-Related Protein That Functions in BMP2 Signaling 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phosphorylated in response to transforming growth factor β and are implicated in control of cell growth"}]},{"@id":"https://cir.nii.ac.jp/crid/1570854176741551872","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"An FGF signal from endoderm and localized factors in the posterior-vegetal egg cytoplasm pattern the mesodermal tissues in the ascidian embryo"}]},{"@id":"https://cir.nii.ac.jp/crid/1570854176742437376","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"posterior end mark 3(pem-3), an ascidian maternally expressed gene with localized mRNA encodes a protein with Caenorhabditis elegans MEX-3-like KH domeins"}]},{"@id":"https://cir.nii.ac.jp/crid/1571135649647634432","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"An ascidian homologue of vertebrate BMPs-5-8 is expressed in the midline of the anterior neuroectoderm and in the midline of the ventral epidermis of the embryo"}]},{"@id":"https://cir.nii.ac.jp/crid/1571135651708551296","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Smad6 functions as an intracellular antagonist of someTGF-β family members during Xenopus embryogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1571417126643539968","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1571417126692167168","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The Drosophila activin receptor baboon signals through dSmad2 and controls cell proliferation but not patterning during larval development"}]},{"@id":"https://cir.nii.ac.jp/crid/1571698599278860928","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Genetic characterization and cloning of Mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster"}]},{"@id":"https://cir.nii.ac.jp/crid/1571698599310265216","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A model of evolutionary change in protein"}]},{"@id":"https://cir.nii.ac.jp/crid/1571698601647565312","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Xenopus Mad proteins transduce distinct subsets of signals for the TGF-β superfamily"}]},{"@id":"https://cir.nii.ac.jp/crid/1571698601656816512","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Smads and early developmental signaling by the TGF-β superfamily"}]},{"@id":"https://cir.nii.ac.jp/crid/1571980074614690048","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Genomic structure of the human Smad3 gene and its infrequent alterations in coloectal cancers"}]},{"@id":"https://cir.nii.ac.jp/crid/1571980074614691072","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Medea is a Drosophila Smad4 homolog that is differentially required to potentiate DPP responses"}]},{"@id":"https://cir.nii.ac.jp/crid/1571980075740380416","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Daughters against dpp modulates dpp organizing activity in Drosophila wing development"}]},{"@id":"https://cir.nii.ac.jp/crid/1572261550718270208","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A human Mad protein acting as a BMP-regulated transcriptional activator"}]},{"@id":"https://cir.nii.ac.jp/crid/1572543024003015680","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The neighbor-joining method : a new method for reconstructing phylogenetic trees"}]},{"@id":"https://cir.nii.ac.jp/crid/1572543024531185664","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Induction of brain and sensory pigment cells in the ascidian embryo analyzed by experiments with isolated blastomeres"}]},{"@id":"https://cir.nii.ac.jp/crid/1572543024568111360","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Basic fibroblas groeth factor induces notochord formation and the expression of As-T, a brachyury homolog, during ascidian embryogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1572824501550125568","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1572824501554406656","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"MADR1, a MAD-related protein that functions in BMP2 signaling pathways"}]},{"@id":"https://cir.nii.ac.jp/crid/1573387449498242432","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Cell-fate specification by localized cytoplasmic determinants and cell interactions in ascidian embryos"}]},{"@id":"https://cir.nii.ac.jp/crid/1573387449498338048","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Functional analysis of an ascidian homologue of vertebrate Bmp-2/Bmp-4 suggests its role in the inhibition of neural fate specification"}]},{"@id":"https://cir.nii.ac.jp/crid/1573668925603710464","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"MADR2 maps to 18q21 and encodes a TGFβ-regulated MAD-related protein in colorectal carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1573950399451665792","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"TGF-β signaling, Smads, and tumor 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member of the FGFR family, HrFGFR, in Halocynthia roretzi"}]}],"dataSourceIdentifier":[{"@type":"IRDB","@value":"oai:irdb.nii.ac.jp:01221:0000074427"},{"@type":"NDL_SEARCH","@value":"oai:ndlsearch.ndl.go.jp:R000000004-I6409267"},{"@type":"NDL_SEARCH","@value":"oai:ndlsearch.ndl.go.jp:R100000039-I10864155"},{"@type":"CROSSREF","@value":"10.2108/zsj.18.833"},{"@type":"NDL_DC","@value":"info:ndljp/pid/10864155"},{"@type":"CIA","@value":"110003371989"},{"@type":"OPENAIRE","@value":"doi_dedup___::c71a23ca63e6616ee7df675491f3f4b2"}]}