Cinnamic acid promotes elongation of hair peg-like sprouting in hair follicle organoids via oxytocin receptor activation

DOI 機関リポジトリ 機関リポジトリ (HANDLE) PDF Web Site 被引用文献2件 参考文献28件 オープンアクセス
  • Kageyama, Tatsuto
    Kanagawa Academy Science & Technology Fac Engn, Yokohama National University
  • Seo, Jieun
    Fac Engn, Yokohama National University Fac Engn, Inst Adv Sci, Yokohama National University
  • Yan, Lei
    Kanagawa Academy Science & Technology Fac Engn, Yokohama National University
  • Fukuda, Junji
    Kanagawa Academy Science & Technology Fac Engn, Yokohama National University

書誌事項

公開日
2024-02-27
資源種別
journal article
権利情報
  • Creative Commons Attribution 4.0 International
DOI
  • 10.1038/s41598-024-55377-y
公開者
Nature Portfolio

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説明

Considerable global demand exists for the development of novel drugs for the treatment of alopecia. A recent report demonstrated that oxytocin promotes hair growth activity in human dermal papilla (DP) cells; however, its application in drugs or cosmetic products is challenging because rapid degradation and relatively large molecular weight prevent long-term topical administration on the scalp. Here, we examined cinnamic acid, a small molecule activator for oxytocin receptor (OXTR) expression. Treatment with cinnamic acid led to upregulation of OXTR and trichogenic gene expression in human DP cells. Furthermore, inhibition of OXTR with an antagonist, L-371,257, suppressed hair growth-related gene expression in DP cells. These findings suggest that cinnamic acid enhances the hair growth ability of DP cells via oxytocin signaling. Additionally, we tested the hair growth-promoting effects of cinnamic acid using hair follicle organoids in vitro and observed that cinnamic acid significantly promoted the growth of hair peg-like sprouting. These promising results may be useful for developing hair growth-promoting products targeting oxytocin.

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