Mechano-gradients drive morphogen-noise correction to ensure robust patterning

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Bibliographic Information

Published
2024-11-15
Resource Type
journal article
Rights Information
  • This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
DOI
  • 10.1126/sciadv.adp2357
Publisher
American Association for the Advancement of Science (AAAS)

Description

Aoki Kana, Higuchi Taiki, Akieda Yuki, et al. Mechano-gradients drive morphogen-noise correction to ensure robust patterning. Science Advances 10, 337 (2024); https://doi.org/10.1126/sciadv.adp2357.

Morphogen gradients instruct cells to pattern tissues. Although the mechanisms by which morphogens transduce chemical signals have been extensively studied, the roles and regulation of the physical communication between morphogen-receiver cells remain unclear. Here, we show that the Wnt/β-catenin–morphogen gradient, which patterns the embryonic anterior-posterior (AP) axis, generates intercellular tension gradients along the AP axis by controlling membrane cadherin levels in zebrafish embryos. This “mechano-gradient” is used for the cell competition–driven correction of noisy morphogen gradients. Naturally and artificially generated unfit cells, producing noisy Wnt/β-catenin gradients, induce local deformation of the mechano-gradients that activate mechanosensitive calcium channels in the neighboring fit cells, which then secrete annexin A1a to kill unfit cells. Thus, chemo-mechanical interconversion–mediated competitive communication between the morphogen-receiver cells ensures precise tissue patterning.

Journal

  • Science Advances

    Science Advances 10 (46), 2024-11-15

    American Association for the Advancement of Science (AAAS)

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